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  • anti-HIV antibody
  • The new finding about Apobec3 suggests that this gene may influence anti-HIV antibody production and may help explain why some people who are repeatedly exposed to the virus never become infected. (emaxhealth.com)
  • The idea that Apobec3 can influence not only the ability of HIV to cause infection but also antibody responses to the virus is supported by a previous study demonstrating that the human chromosomal region containing several Apobec3 genes is linked to anti-HIV antibody responses in a group of Italian subjects who were repeatedly exposed to the virus by their HIV-infected partners but remained uninfected. (emaxhealth.com)
  • Researchers at The Scripps Research Institute have uncovered the surprising details of how a powerful anti-HIV antibody grabs hold of the virus. (medindia.net)
  • It also can do so much more potently in other words, in smaller concentrations of antibody molecules than any previously reported broadly neutralizing anti-HIV antibody. (medindia.net)
  • gp120
  • The antibody binds to gp120 in a way that presumably disrupts its ability to lock onto human cells and infect them. (medindia.net)
  • Yet it doesn't bind to gp120 many times more tightly than other anti-HIV antibodies. (medindia.net)
  • He repeatedly donated blood over the course of a year, which researches used to create a timeline of changes in his virus' gp120, his antibody response and the ultimate emergence of a bNAb. (wikipedia.org)
  • A screen of massive gp120 libraries led to one that strongly bound both an original antibody and the mature bNAb that evolved from it. (wikipedia.org)
  • Giving patients a modified gp120 that contains little more than the epitope that both antibodies target could act to "prime" the immune system, followed by a booster that contains trimer spikes in the most natural configuration possible. (wikipedia.org)
  • vaccine
  • While a vaccine "trains" the immune system to generate antibodies and other immune responses, passive immunization requires that the antibodies be delivered directly into the body through repeat infusions or injections. (iavi.org)
  • Antibody immunoprophylaxis, if effective, could augment existing HIV prevention strategies and help limit the spread of the virus until a vaccine is developed. (iavi.org)
  • A vaccine that can elicit a broadly neutralizing effect is needed for a vaccine to be fully effecive for everyone. (aumag.org)
  • What's unexpected and unique about this antibody is that it not only attaches to the sugar coating of the virus but also reaches through to grab part of the virus's envelope protein," said the report's co-senior author Dennis Burton, a professor at The Scripps Research Institute and scientific director of the International AIDS Vaccine Initiative's (IAVI) Neutralizing Antibody Center, based on the Scripps Research La Jolla campus. (medindia.net)
  • Besides the conformation of the linear epitope, 2F5-like responses to vaccine are complicated by the fact that antibody recognition of the epitope may also be dependent on interactions with other areas of the env region, accessibility, or interactions with membrane lipids on target cells. (wikipedia.org)
  • Human monoclonal antibodies and vaccine design: Taking advantage of his studies on human memory B cells (16), Lanazvecchia developed novel and robust methods to immortalize human memory B cells and to preserve single plasma cells in culture (17, 18). (wikipedia.org)
  • The methods to isolate human monoclonal antibodies developed by Lanzavecchia have realized a long-sought goal: the full exploitation of the human immune response for serotherapy and vaccine design. (wikipedia.org)
  • gp41
  • Research has suggested that a two-step process is necessary for 2F5 binding and neutralizing: recognition of the epitope on gp41 and a hydrophobic interaction with the lipid membrane of the virus by the 2F5 CDR H3 loop. (wikipedia.org)
  • bNAb
  • The screening process for the study included tests to assess whether HIV resistance to either bNAb could be detected in viruses grown from the latent reservoir, and individuals with samples displaying evidence of resistance were excluded (approximately half the individuals screened could not enroll due to evidence of resistance to one of the antibodies). (thebodypro.com)
  • bNAb loops are typically longer than ordinary antibodies, increasing the variety of epitopes they can capture. (wikipedia.org)
  • In 1990, researchers identified the first HIV bNAb, far more powerful that any antibody seen before. (wikipedia.org)
  • 3BNC117
  • Discovered and developed by Dr. Michel Nussenzweig , head of the Laboratory of Molecular Immunology, Zanvil A. Cohn and Ralph M. Steinman Professor of The Rockefeller University , as well as a Howard Hughes Medical Institute investigator, 3BNC117 is one of the most effective broad-spectrum HIV neutralizing antibodies. (medindia.net)
  • viruses
  • Further analysis revealed that the viral load in the body, the diversity of viruses found in that individual, and how long the patient went without treatment were key factors in determining which patients produced these antibodies. (the-scientist.com)
  • antiviral
  • We knew that Apobec3 had very interesting antiviral properties, but this new discovery that it affects antibody responses will generate even greater interest in both Apobec3 and Vif. (emaxhealth.com)
  • neutralization
  • Electron microscopy, PCR, complement fixation, antibody fluorescence, neutralization test, and haemagglutination can be used to identify the virus in tissues or secretions. (wikipedia.org)
  • Studies in thermodynamics have further supported this: IgG has a much higher binding affinity than just the Fab region of the antibody, suggesting the constant region is important to neutralization. (wikipedia.org)
  • virus
  • The finding adds a new dimension to the set of possible explanations for why most people who are infected with HIV do not make neutralizing antibodies that effectively fight the virus. (emaxhealth.com)
  • Virus-neutralizing activity against SPPV in lamb kidney cell culture was detected for polyclonal antisera raised to SPPV-060, SPPV-117, and SPPV-122 proteins. (mdpi.com)
  • To our knowledge, this is the first report demonstrating the virus-neutralizing activities of antisera raised to SPPV-060, SPPV-117, and SPPV-122 proteins. (mdpi.com)
  • Neutralizing antibodies were isolated against SARS, cytomegalovirus, avian influenza and dengue virus. (wikipedia.org)
  • immunogenicity
  • Through the intelligent and experienced application of cell-based neutralizing antibody assays, Intertek is the ideal partner for your biologic drug development or pharmacovigilance requirements for immunogenicity testing . (intertek.com)
  • human
  • The scientists who conducted the study hypothesize that Apobec3 in humans might play a similar role in helping shape the neutralizing antibody response to human retroviruses such as HIV. (emaxhealth.com)
  • responses
  • In addition, the scientists discovered that versions of Rfv3 that fail to make antibody responses correlate with a natural defect in Apobec3. (emaxhealth.com)
  • mechanism
  • Cell-based neutralizing antibody assays can be difficult to develop as the selection of the most suitable assay type (indirect or direct) and format depends on thorough understanding of the drug's mechanism of action. (intertek.com)
  • Advances
  • Technological advances have made it possible to identify, characterize, optimize, and manufacture antibodies like never before. (iavi.org)
  • multiple
  • With multiple applications in biomedicine, the antibodies can now be made quickly, cheaply, and without the need for an alpaca or one of its relatives. (the-scientist.com)