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  • mice
  • Treatment of mice bearing BCL1 lymphoma with bispecific antibodies. (ac.be)
  • According to Michael Festing's Inbred Strains of Mice, BALB/c substrains are "particularly well known for the production of plasmacytomas on injection with mineral oil," an important process for the production of monoclonal antibodies. (wikipedia.org)
  • autoimmune
  • Autoimmune autonomic ganglionopathy (AAG) is an extremely rare form of dysautonomia in which the patients immune system produces ganglionic AChR antibodies, inhibiting ganglionic AChR currents and impairing transmission in autonomic ganglia. (wikipedia.org)
  • fragments
  • To improve the imaging agent, multiple versions of humanized PSCA antibody fragments were created and subsequently tested for their abilities to image in vivo using micro-PET, with the goal to eventually detect distant metastases. (dtic.mil)
  • The Fab fragments contain the variable domains, which consist of three antibody hypervariable amino acid domains responsible for the antibody specificity embedded into constant regions. (wikipedia.org)
  • Patients
  • A Phase I study of Milatuzumab, a humanized anti-CD74 antibody, and Veltuzumab, a humanized anti-CD20 antibody, in patients with relapsed and refractory B-cell non-Hodgkin's lymphoma. (wikipedia.org)
  • date=16 June 2010 A Study of hLL1-DOX (Milatuzumab-Doxorubicin Antibody-Drug Conjugate) in Patients With Multiple Myeloma. (wikipedia.org)
  • The seronegative patients (those without detectable gAChR levels) are theorized to have one or more different antibodies responsible for the autonomic dysfunction. (wikipedia.org)
  • immunoglobulin
  • Immunoglobulin G (IgG) antibodies are large heterodimeric molecules, approximately 150 kDa and are composed of two kinds of polypeptide chain, called the heavy (~50kDa) and the light chain (~25kDa). (wikipedia.org)
  • Plasma cells can only produce a single kind of antibody in a single class of immunoglobulin. (wikipedia.org)
  • The immunoglobulin light chain is the small polypeptide subunit of an antibody (immunoglobulin). (wikipedia.org)
  • A typical antibody is composed of two immunoglobulin (Ig) heavy chains and two Ig light chains. (wikipedia.org)
  • There are two types of light chain in humans: kappa (κ) chain, encoded by the immunoglobulin kappa locus (IGK@) on chromosome 2 lambda (λ) chain, encoded by the immunoglobulin lambda locus (IGL@) on chromosome 22 Antibodies are produced by B lymphocytes, each expressing only one class of light chain. (wikipedia.org)
  • functional
  • Camelids are unique among mammals as they also have fully functional antibodies which have two heavy chains, but lack the light chains usually paired with each heavy chain. (wikipedia.org)
  • The B cells in the body have two important phenotypes (functional forms) -- the antibody secreting, terminally differentiated (that is, they cannot divide further) plasma cells, and the memory and the naive cells-both of which retain their proliferative potential. (wikipedia.org)
  • contrary
  • On the contrary, in some neoplasms CD44 upregulation is associated with a favorable outcome. (wikipedia.org)
  • IgNAR is believed to have never had an associated light chain, contrary to the understanding that the heavy-chain-only antibodies in camelids may have lost its light chain partner through evolution. (wikipedia.org)
  • cells
  • The present invention provides a means of inhibiting the growth and metastasis of cancer cells by administering anti-chemokine antibodies. (google.com)
  • However, an important limitation of antibodies is that cells need to be fixed leading to potential artifacts. (wikipedia.org)
  • Plasma cells, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete large volumes of antibodies. (wikipedia.org)
  • Most of these B cells will become plasmablasts (or "immature plasma cells"), and eventually plasma cells, and begin producing large volumes of antibodies. (wikipedia.org)
  • Plasmablasts secrete more antibodies than B cells, but less than plasma cells. (wikipedia.org)
  • For example, plasma cells will likely secrete IgG3 antibodies if they matured in the presence of the cytokine interferon-gamma. (wikipedia.org)
  • Cathepsin K antibodies are marketed for research into expression of this enyzme by various cells. (wikipedia.org)
  • treatment
  • Milatuzumab (or hLL1) is an anti-CD74 humanized monoclonal antibody for the treatment of multiple myeloma non-Hodgkin's lymphoma and chronic lymphocytic leukemia. (wikipedia.org)
  • The drug is the first anti-CD74 antibody that has entered into human testing and is currently being studied for the treatment of multiple myeloma. (wikipedia.org)
  • hLL1-Dox Milatuzumab has been linked to doxorubicin to form an antibody-drug conjugate or ADC (known as hLL1-Dox or IMMU-110) for treatment of relapsed multiple myeloma. (wikipedia.org)
  • symptoms
  • Pubmed ID: 12417508 Somatostatinomas involving the gastrointestinal tract are extremely rare neoplasms that typically present with indolent, nonspecific symptoms in the absence of systemic neuroendocrine manifestations that characterize the somatostatinoma syndrome. (jove.com)
  • human
  • Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: strategies, applications, and limitations. (semanticscholar.org)
  • However the dissimilarity between murine and human immune systems led to the clinical failure of these antibodies, except in some specific circumstances. (wikipedia.org)
  • citation needed] In preclinical studies with human lymphomas and myelomas, both naked Milatuzumab and the Milatuzumab conjugated with doxorubicin, an antibody-drug conjugate or ADC, have demonstrated anti-lymphoma activity in-vivo. (wikipedia.org)
  • Anti-CD74 antibody-doxorubicin conjugate, IMMU-110, in a human multiple myeloma xenograft and in monkeys. (wikipedia.org)
  • drug
  • Milatuzumab-Doxorubicin (IMMU-110 / hLL1-dox) Clinical Trials - ADC Review / Journal of Antibody-drug Conjugates Immunomedics initiates dosing in milatuzumab-doxorubicin conjugate Phase I/II trial for relapsed multiple myeloma - News Medical and Immunomedics Press Release. (wikipedia.org)