• mice
  • Treatment of mice bearing BCL1 lymphoma with bispecific antibodies. (ac.be)
  • According to Michael Festing's Inbred Strains of Mice, BALB/c substrains are "particularly well known for the production of plasmacytomas on injection with mineral oil," an important process for the production of monoclonal antibodies. (wikipedia.org)
  • Conjugates
  • Milatuzumab-Doxorubicin (IMMU-110 / hLL1-dox) Clinical Trials - ADC Review / Journal of Antibody-drug Conjugates Immunomedics initiates dosing in milatuzumab-doxorubicin conjugate Phase I/II trial for relapsed multiple myeloma - News Medical and Immunomedics Press Release. (wikipedia.org)
  • Serum
  • In a healthy individual, the total kappa to lambda ratio is roughly 2:1 in serum (measuring intact whole antibodies) or 1:1.5 if measuring free light chains, with a highly divergent ratio indicative of neoplasm. (wikipedia.org)
  • occur
  • Melanomas are neoplasms of melanin-producing cells (melanocytes or melanoblasts), which can occur in many domestic species and in humans. (agr.ca)
  • Additionally, a blood test showing high levels of the antibody ganglionic nicotenic acetylcholine receptor (gAChr) occur in about 50% of patients with AAG (seropositive AAG). (wikipedia.org)
  • autoimmune
  • Autoimmune autonomic ganglionopathy (AAG) is an extremely rare form of dysautonomia in which the patients immune system produces ganglionic AChR antibodies, inhibiting ganglionic AChR currents and impairing transmission in autonomic ganglia. (wikipedia.org)
  • Surface
  • The humanized antibody to prostate stem cell antigen (PSCA), a cell surface marker on prostate cancer cells, combined with PET scanning was developed to image prostate tumor. (dtic.mil)
  • fragments
  • To improve the imaging agent, multiple versions of humanized PSCA antibody fragments were created and subsequently tested for their abilities to image in vivo using micro-PET, with the goal to eventually detect distant metastases. (dtic.mil)
  • The Fab fragments contain the variable domains, which consist of three antibody hypervariable amino acid domains responsible for the antibody specificity embedded into constant regions. (wikipedia.org)
  • Patients
  • The seronegative patients (those without detectable gAChR levels) are theorized to have one or more different antibodies responsible for the autonomic dysfunction. (wikipedia.org)
  • A Phase I study of Milatuzumab, a humanized anti-CD74 antibody, and Veltuzumab, a humanized anti-CD20 antibody, in patients with relapsed and refractory B-cell non-Hodgkin's lymphoma. (wikipedia.org)
  • date=16 June 2010 A Study of hLL1-DOX (Milatuzumab-Doxorubicin Antibody-Drug Conjugate) in Patients With Multiple Myeloma. (wikipedia.org)
  • cells
  • Abo T, Balch CM (1981) A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). (springer.com)
  • Monoclonal antibodies can target tumor cells or abnormal cells in the body that are recognized as body cells, but are debilitating to one's health. (wikipedia.org)
  • However, an important limitation of antibodies is that cells need to be fixed leading to potential artifacts. (wikipedia.org)
  • Plasma cells, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete large volumes of antibodies. (wikipedia.org)
  • B cells differentiate into plasma cells that produce antibody molecules closely modelled after the receptors of the precursor B cell. (wikipedia.org)
  • Most of these B cells will become plasmablasts (or "immature plasma cells"), and eventually plasma cells, and begin producing large volumes of antibodies. (wikipedia.org)
  • Plasmablasts secrete more antibodies than B cells, but less than plasma cells. (wikipedia.org)
  • Differentiation through a T cell-independent antigen stimulation (stimulation of a B cell that does not require the involvement of a T cell) can happen anywhere in the body and results in short-lived cells that secrete IgM antibodies. (wikipedia.org)
  • For example, plasma cells will likely secrete IgG3 antibodies if they matured in the presence of the cytokine interferon-gamma. (wikipedia.org)
  • Cathepsin K antibodies are marketed for research into expression of this enyzme by various cells. (wikipedia.org)
  • The B cells in the body have two important phenotypes (functional forms) -- the antibody secreting, terminally differentiated (that is, they cannot divide further) plasma cells, and the memory and the naive cells-both of which retain their proliferative potential. (wikipedia.org)
  • functional
  • Camelids are unique among mammals as they also have fully functional antibodies which have two heavy chains, but lack the light chains usually paired with each heavy chain. (wikipedia.org)
  • contrary
  • On the contrary, in some neoplasms CD44 upregulation is associated with a favorable outcome. (wikipedia.org)
  • IgNAR is believed to have never had an associated light chain, contrary to the understanding that the heavy-chain-only antibodies in camelids may have lost its light chain partner through evolution. (wikipedia.org)
  • affinity
  • The antibody was successful in preclinical model, although humanization caused a loss of affinity relative to the parental monoclonal antibody. (dtic.mil)
  • Since B cell maturation also involves somatic hypermutation (a process completed before differentiation into a plasma cell), these antibodies frequently have a very high affinity for their antigen. (wikipedia.org)
  • human
  • Four major antibody types that have been developed are murine, chimeric, humanised and human. (wikipedia.org)
  • However the dissimilarity between murine and human immune systems led to the clinical failure of these antibodies, except in some specific circumstances. (wikipedia.org)
  • The drug is the first anti-CD74 antibody that has entered into human testing and is currently being studied for the treatment of multiple myeloma. (wikipedia.org)
  • citation needed] In preclinical studies with human lymphomas and myelomas, both naked Milatuzumab and the Milatuzumab conjugated with doxorubicin, an antibody-drug conjugate or ADC, have demonstrated anti-lymphoma activity in-vivo. (wikipedia.org)
  • Anti-CD74 antibody-doxorubicin conjugate, IMMU-110, in a human multiple myeloma xenograft and in monkeys. (wikipedia.org)
  • important
  • The single most important and frequent group of neoplasms is the gliomas which can be subdivided, according to the three major cell types, into astrocytomas, oligodendrocytomas and ependymomas. (springer.com)
  • treatment
  • Milatuzumab (or hLL1) is an anti-CD74 humanized monoclonal antibody for the treatment of multiple myeloma non-Hodgkin's lymphoma and chronic lymphocytic leukemia. (wikipedia.org)
  • hLL1-Dox Milatuzumab has been linked to doxorubicin to form an antibody-drug conjugate or ADC (known as hLL1-Dox or IMMU-110) for treatment of relapsed multiple myeloma. (wikipedia.org)
  • symptoms
  • Pubmed ID: 12417508 Somatostatinomas involving the gastrointestinal tract are extremely rare neoplasms that typically present with indolent, nonspecific symptoms in the absence of systemic neuroendocrine manifestations that characterize the somatostatinoma syndrome. (jove.com)
  • prostate
  • The antibody reacted with carcinomas of the cervix (CaSki, HeLa), prostate (PC-3), breast (ZR-76-1), colon (COLO-205) and melanoma (G-361) but was negative for normal fibroblasts (WI-38 and MRC-9), T. lymphocytes and peripheral blood lymphocytes. (atcc.org)
  • large
  • The meninges ensheathing the CNS also give rise to a group of neoplasms, the meningiomas which appear to have an increasingly large number of subtypes. (springer.com)