• phage therapy
  • He has made important contributions regarding the physical basis of transcriptional regulation in bacteria, the lysis/lysogeny switch in lambda phage, the organization of the bacterial nucleoid, and phage therapy. (wikipedia.org)
  • acute
  • However, for serious acute cases of pyelonephritis or bacterial prostatitis where the patient may need to be hospitalised, fluoroquinolones are recommended as first-line therapy. (wikipedia.org)
  • vitro
  • REP3123 is a new narrow spectrum antibacterial agent that in vitro prevents the growth of C. difficile by in hibiting an essential enzyme inthe bacterial cell called methionyl tRNA synthetase, which blocks the organism from synthesizing proteins. (emaxhealth.com)
  • In assays against M. smegmatis the Galf 9-heptadecyl thioglycoside was found to be the most active compound with an in vitro potency of 1 µg/mL, comparable to the frontline anti-TB drug ethambutol (1-4 µg/mL). (edu.au)
  • In addition, the thioglycoside displayed excellent broad spectrum Gram positive anti-bacterial activity in vitro, but was not active at concentrations below 64 µg/mL against a Gram negative organism. (edu.au)
  • infection
  • If the causative agent of the infection is known, the use of narrow-spectrum antibacterial agents has the potential to mitigate some of these issues. (rsc.org)
  • When Keflex is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. (pharmacycode.com)
  • With this in mind, the work covered in this thesis focused on the preparation of novel carbohydrate-based compounds as potential anti-bacterial agents, in particular targeted to mycobacterial infection. (edu.au)
  • This is evident, as the treatment dosage is much too low to fight infection, and in DPB cases with the occurrence of the macrolide-resistant bacterium Pseudomonas aeruginosa, macrolide therapy still produces substantial anti-inflammatory results. (wikipedia.org)
  • An eye drop may be used for a superficial bacterial infection of the eye and an ear drop may be used for otitis media when there is a hole in the ear drum. (wikipedia.org)
  • species
  • The arrangement of spore layers is as follows: Exosporium Spore coat Spore cortex Core wall The position of the endospore differs among bacterial species and is useful in identification. (wikipedia.org)
  • pathogenic
  • With minimal projected side-effects, owing to the lack of Galf residues in mammalian systems, hydrolytically-stable Galf analogues were selected as promising targets for the development of potential therapeutic agents against Galf containing pathogenic micro-organisms. (edu.au)
  • This potent antibacterial activity extended to known multi-resistant strains of pathogenic bacteria, such as those of Klebsiella oxytoca. (wikipedia.org)
  • spores
  • At 0.5 times the MIC, REP3123 was the most effective agent at preventing the production of spores in all strains (equal to or less than 1% of spores after 96 hours of treatment). (emaxhealth.com)
  • Astrophysicist Steinn Sigurdsson said "There are viable bacterial spores that have been found that are 40 million years old on Earth - and we know they're very hardened to radiation. (wikipedia.org)
  • growth
  • VS could inhibit the growth of S. aurous and E. coli , and adding glycine or EDTA improved VS antibacterial activity presumably via instability of the cell wall and enhanced transport of VS through bacterial cell wall. (hindawi.com)
  • Since the early steps of isoprenoid biosynthesis pathway (mevalonate kinase) in eukaryotes resemble bacterial isoprenoid biosynthesis and regarding the fact that VS inhibits the mevalonate pathway in eukaryotic organisms [ 10 ], we examined the effect of VS as a nonselective mevalonate kinase inhibitor on bacterial isoprenoid biosynthesis and its impact on bacterial growth. (hindawi.com)
  • Replidyne's antibacterial candidate REP3123 is shown to in hibit growth and prevent spore-forming of the Gram-positive Clostridium difficile (C. difficile) bacterium without inhibiting other key organisms that are essential for normal intestinal functioning. (emaxhealth.com)
  • One approach to developing new antibacterial strategies, taken by researchers from the University of Washington, Seattle, is to limit the amount of iron (Fe), which is critical for bacterial growth, to which bacteria have access. (bio-medicine.org)
  • In this way, can determine which substance has the best antibacterial effect and which concentration should be used inside implants to avoid bacterial growth. (austinpublishinggroup.com)
  • This either stops growth or results in bacterial death. (wikipedia.org)
  • susceptible
  • Carbapenems are less commonly used in the treatment of community-acquired pneumonia, as community-acquired strains of the most common responsible pathogens (Streptocuccus pneumoniae, Haemophilus influenazae, atypical bacteria, and Enterobactericeace) are typically susceptible to narrower spectrum and/or orally administered agents such as fluoroquinolones, amoxicillin, or azithromycin. (wikipedia.org)
  • Chapter
  • For the purpose of investigating the requirement for a galactofuranose glycan moiety for anti-bacterial activity, the aglycons of the more active galactofuranosyl compounds (Chapter 2) were introduced onto alternate furanose sugars. (edu.au)
  • This chapter provides an overview of the antibacterial agents currently marketed in the United States, with major emphasis on their mechanisms of action, spectra of activity, important pharmacologic parameters, and toxicities. (asmscience.org)
  • cell wall
  • Interference with the incorporation of Galf into this polysaccharide was expected to compromise the physical integrity of the bacterial cell wall leading to cell death. (edu.au)
  • treatment
  • A 2015 meta analysis concluded that the anti-pseudomonal penicillin-beta lactamase inhibitor combination piperacillin-tazobactam gives results equivalent to treatment with a carbapenem in patients with sepsis. (wikipedia.org)
  • A variety of drugs act as inhibitors of dihydrofolate reductase: the experimental antimalarial and anti-toxoplasmosis compound JPC-2056 Oral piritrexim, a treatment for metastatic urothelial cancer. (wikipedia.org)
  • However, in the absence of such anti-odour treatment they quickly become notoriously foul-smelling. (wikipedia.org)
  • treat
  • During World War II, the Soviet Union used bacteriophages to treat many soldiers infected with various bacterial diseases e.g. dysentery and gangrene. (wikipedia.org)
  • activity
  • As a result of this finding, a study of structure activity relationships (SAR) of galactofuranose derivatives as antibacterial agents has been undertaken. (edu.au)
  • In addition, the aglycon units incorporated were designed in order to identify the necessary characteristics for optimum anti-bacterial activity, and included aglycons both aromatic and aliphatic in character. (edu.au)
  • This series of compounds (containing either sulfenamide or sulfonamide functionality) were prepared to investigate the requirement of a carbohydrate moiety for anti-bacterial activity. (edu.au)
  • Agents with anti-pseudomonal activity, including doripenem, imipenem, and meropenem are not recommended in this population. (wikipedia.org)
  • cells
  • Although some of the largest and most complex bacterial cells belong to the Actinobacteria, the group of marine Actinomarinales has been described as possessing the smallest free-living prokaryotic cells. (wikipedia.org)
  • However
  • However, the sheer numbers and continuing development of agents make it difficult for clinicians to keep up with progress in the field. (asmscience.org)
  • currently
  • Hundreds of antimicrobial agents have been developed or synthesized to date, and a broad number and variety of agents are currently available for clinical use. (asmscience.org)