• 1989
  • In order to secure funding for a start-up company based on family funds, the Changs sought collaboration with Genentech in 1989, sending data and samples of early anti-IgE antibody, but talks with Genentech were unsuccessful. (wikipedia.org)
  • receptor
  • Meclizine, a piperazine-derivative H 1 -receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. (pharmacycode.com)
  • nausea
  • The most common adverse effects noted for second-generation agents include drowsiness, fatigue, headache, nausea and dry mouth. (wikipedia.org)
  • allergy
  • Proxicromil was developed in the late 1970s as an oral analogue and a successor of anti-allergy drug Intal, whose patent protection period was to expire in 1982. (wikipedia.org)
  • various
  • Urushiol-induced contact dermatitis (also called Toxicodendron dermatitis and Rhus dermatitis) is the medical name given to allergic rashes produced by the oil urushiol, which is contained in various plants, most notably those of the Toxicodendron genus: the Chinese lacquer tree, poison ivy, poison oak, and poison sumac. (wikipedia.org)
  • Activity
  • Besides its anti-histaminic activity, it is also a functional leukotriene antagonist and a phosphodiesterase inhibitor. (wikipedia.org)
  • early
  • Pirquinozol (SQ-13,847) is a drug which was investigated as an antiallergen and antiasthmatic agent in the early 1980s but was never marketed. (wikipedia.org)