• receptor
  • The data obtained with the angiotensin receptor subtype-selective compounds, losartan and PD 123319, suggest that the depressor action is an AT 1 -mediated effect and give no indication that AT 2 receptors could be involved. (ahajournals.org)
  • gene
  • Some strains of mice appear to carry a duplication of the renin structural gene (Ren-2) near the Ren-1 locus. (ahajournals.org)
  • Sequence analysis of a 319 bp renin cDNA recombinant isolated from a kidney library from the two-gene strain DBA/2Ha corresponds to a transcript of the Ren-1 gene. (ahajournals.org)
  • activity
  • Our experiments also address the hypothesis that angiotensinogenic depressor responses could be mediated by non-AT 1 /AT 2 receptors, because of the experiments by Haberl 6 described above and the observation that angiotensin IV and angiotensin-(1-7) have dilator or depressor activity. (ahajournals.org)
  • study
  • 11 An AT 2 -mediated dilator action is further supported by a study of Li et al, 12 who reported that angiotensin III contractile responses in rat aorta were accentuated by PD 123177 but that angiotensin II and IV responses were unaffected. (ahajournals.org)