• genetic
  • Additionally, it has been suggested ( 21 ) that the phenotypes detected in the disomic strains may be a unique consequence of the method that was used to generate aneuploidy, in which genetic markers were used to select for rare chromosome transfer events between nuclei ( 13 ). (pnas.org)
  • The test will analyze circulating cell free fetal (ccff) nucleic acid from blood samples from pregnant women who have an increased risk indicator/s for fetal chromosomal aneuploidy and are undergoing invasive prenatal diagnosis by chorionic villus sampling (CVS) and/or genetic amniocentesis. (clinicaltrials.gov)
  • The results of the ccff aneuploidy test will be compared to the chromosomal analysis obtained via CVS or genetic amniocentesis. (clinicaltrials.gov)
  • This study will allow for first of its kind commercial PGS/D testing to detect disease-associated genetic mutations together with aneuploidy screening. (clinicaltrials.gov)
  • Meiosis II-nondisjunction may also result in aneuploidy syndromes, but only to a much smaller extent than do segregation failures in meiosis I. Division of somatic cells through mitosis is preceded by replication of the genetic material in S phase. (wikipedia.org)
  • yeast
  • We investigated whether pleiotropic stress could induce the production of aneuploidy in budding yeast. (ku.edu)
  • We provided a proof-of-principle test with mechanistic explanation in budding yeast and demonstrated the potential efficacy of this strategy toward aneuploidy-based azole resistance in the human pathogen Candida albicans. (ku.edu)
  • Genomic
  • Aneuploidy can be detected with the help of traditional metaphase cytogenetics, interphase cytogenetics (fluorescent in situ hybridisation (FISH), multicolour FISH, spectral karyotyping, and comparative genomic hybridisation techniques (CGH)), flow cytometry (FCM), and image cytometry (ICM). (bmj.com)
  • fetus
  • This prospective blinded study will assess the diagnostic capability of an informatics enhanced SNP based technology (Parental Support) to identify pregnant women who are carrying a fetus with an aneuploidy from fee floating DNA in the maternal blood. (clinicaltrials.gov)
  • Aneuploidy of autosomes is not well tolerated and usually results in miscarriage of the developing fetus. (wikipedia.org)
  • frequent
  • Examples include: In cancer cells, aneuploidy is a frequent event, indicating that these cells present a defect in the machinery involved in chromosome segregation, as well as in the mechanism ensuring that segregation is correctly performed. (wikipedia.org)
  • karyotypes
  • Short-term exposure to Hsp90 stress, which produced an aneuploidy population with heterogeneous karyotypes, potentiated fast adaptation to unrelated cyto-toxic compounds through different aneuploid chromosome stoichiometries. (ku.edu)
  • heterogeneous
  • the potential therapeutic strategy towards these heterogeneous aneuploidy populations with high adaptability, a root for the clinical challenge in treating aneuploidy diseases such as cancer. (ku.edu)
  • We designed an evolutionary trap to harness the adaptability of heterogeneous aneuploidy populations with high adaptability. (ku.edu)
  • genes
  • Failure of the spindle checkpoint caused by mutation of the responsible genes may be one of the important factors for the development of aneuploidy. (bmj.com)
  • Finally, we identified 23 genes whose expression is significantly altered in all aneuploids and which may thus serve as aneuploidy markers. (uni-muenchen.de)
  • cellular
  • Whereas polyploidy is reasonably well tolerated on both the cellular and organismal level, aneuploidy is not, with the condition frequently being associated with death and severe developmental abnormalities in all organisms analyzed to date ( 1 ). (aacrjournals.org)
  • maternal
  • the comparison of peak profiles obtained from IUL, placental, and maternal samples confirmed the diagnosis of aneuploidy in all three cases. (hindawi.com)