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  • nerve
  • The facial nerve lies some distance from the inferior alveolar nerve within the parotid salivary gland, but in rare cases anesthetic can be injected far enough posteriorly to anesthetize that nerve. (wikipedia.org)
  • Sodium
  • Local anesthetics reduce impulse transmission by interfering with the mechanism of normal depolarization, binding to specific receptors located at the nerve membrane-more specifically, on the voltage-gated, tetrodoxin-sensitive sodium channel-and resulting in decreased or eliminated permeability to sodium ions, leading to interruption of nerve conduction. (lww.com)
  • Moreover, other factors of pharmacodynamic origin have been implicated, such as antagonistic effects of nucleotides or increased sodium concentration, increased afferent input from nociceptors, or receptor downregulation of the sodium channels, and often the interpretation is quite difficult because of time-dependent variations in pain or circadian changes in the duration of local anesthetic action: phenomena that are named pseudotachyphylaxis (5) . (lww.com)
  • Local anesthetics act on the voltage-gated sodium channels that conduct electrical impulses and mediate fast depolarization along nerves. (wikipedia.org)
  • Local anesthetics also act on potassium channels, but they block sodium channels more. (wikipedia.org)
  • synergistically
  • Small-dose intraspinal local anesthetics, when added to either epidural or intrathecal opioids, synergistically enhance the antinociceptive effects of the opioid dose, as demonstrated by isobolographic analysis (2) , likely because of inhibition of neuronal excitability. (lww.com)
  • duration
  • Tachyphylaxis to local anesthetics is defined as a decrease in duration, segmental spread, or intensity of analgesia despite repeated constant dosages. (lww.com)
  • The duration of the block is mostly influenced by the amount of time the anesthetic is near the nerve. (wikipedia.org)
  • There are short acting (45-90 minutes), intermediate duration (90-180 minutes), and long acting anesthetics (4-18 hours). (wikipedia.org)
  • ester
  • About one in 3000 white North Americans is homozygotic (i.e. has two copies of the abnormal gene) for the most common atypical form of the enzyme pseudocholinesterase, and do not hydrolyze ester anesthetics such as procaine. (wikipedia.org)
  • analgesia
  • The development of tolerance to morphine is delayed, and the quality of analgesia can be improved because of the morphine-sparing effect of local anesthetics (3) . (lww.com)
  • pain
  • The anesthetic effect will be evaluated using a standardized human sensory and pain model. (clinicaltrials.gov)
  • As a doctor I never inflict uncessary pain to a patient when there are options such as local anethesia. (foot.com)
  • abbreviation
  • The mixture is an oil with a melting point of 18°C. A 5% emulsion preparation, containing 2.5% each of lidocaine/prilocaine, is marketed by APP Pharmaceuticals under the trade name EMLA (an abbreviation for Eutectic Mixture of Local Anesthetics). (wikipedia.org)
  • treatment
  • When a keratitis is unresponsive to treatment and associated with strong ocular pain, topical anesthetic abuse should be considered, and a history of psychiatric disorders and other substance abuse have been implicated as important factors in the diagnosis. (wikipedia.org)
  • Continuous wound infiltration first appeared on the market in the late 1990s when a US company (I-Flow Corporation) found a way to evenly spread and continuously infiltrate a local anesthetic via a specially designed multi holed catheter inside the wound, to enable post-op pain treatment. (wikipedia.org)
  • The limiting factor of the single shot approach has always been the half-life period of the local anesthetics which would not allow a long term post-op pain treatment. (wikipedia.org)
  • enough
  • There was no way they gave me enough anesthetic for that one and I had no sedation or anything. (blogspot.com)
  • The deeper and the larger a foreign object which should be removed lies within the cornea and the more complicated it is to remove it, the more drops of topical anesthetic are necessary prior to the removal of the foreign object to numb the surface of the eye with enough intensity and duration. (wikipedia.org)
  • population
  • To the local population of Nainital and Almora, Baba Hari Dass was also known as Haridas (lit "servant of Lord Hari"), as Haridas Baba, as Chota Maharaji (literally "little great king"), or as Harda Baba. (wikipedia.org)
  • pass
  • Get the most out of your experience with a personalized all-access pass to everything local on events, music, restaurants, news and more. (dallasobserver.com)