• estrogen
  • 17β-HSD2 is involved in inactivation of androgens and estrogens, being accurately describable as "antiandrogenic" and "antiestrogenic", and is the key 17β-HSD isozyme in androgen and estrogen inactivation. (wikipedia.org)
  • Anordrin (former developmental code name AF-53), also known as 2α,17α-diethynyl-A-nor-5α-androstane-2β,17β-diol dipropionate, is a synthetic, steroidal selective estrogen receptor modulator (SERM) which is used in China as an emergency contraceptive. (wikipedia.org)
  • regulates
  • Through the ERβ, 3β-diol positively regulates oxytocin neurons and signaling in the paraventricular nucleus of hypothalamus (PVN), and has been found to have antidepressant, anxiolytic, cognitive-enhancing, and stress-relieving effects via this action. (wikipedia.org)
  • T(3) rapidly regulates several steps of alpha subunit glycoprotein (CGA) synthesis and secretion in the pituitary of male rats: potential repercussions on TSH, FSH and LH secretion. (publish.csiro.au)
  • enzyme
  • 17β-HSD2 activity has also been associated with endometriosis and osteoporosis, and inhibitors of the enzyme are of potential interest in the treatment of the latter condition. (wikipedia.org)
  • 17β-HSD2, an enzyme with broad tissue distribution (Casey et al. (wikipedia.org)
  • enzymes
  • Various antidepressants, including the SSRIs fluoxetine, fluvoxamine, sertraline, and paroxetine, the SNRI venlafaxine, and mirtazapine, have been found to activate certain 3α-HSD enzymes, resulting in a selective facilitation of 5α-dihydroprogesterone conversion into allopregnanolone. (wikipedia.org)
  • deficiency
  • While the exact definition of androgen deficiency remains controversial, the Princeton Consensus in 2001 (3) tried to create a framework for androgen replacement. (ispub.com)
  • Inactivating mutations resulting in a syndrome of congenital deficiency of 17β-HSD2 have not been reported to date. (wikipedia.org)
  • Cancer
  • To extend our understanding of any stepwise genetic alterations that may underlie the assumed clinical progression from early- to late-stage ovarian cancer, CGH 3 (14) was used to identify regions of genome loss and gain in the same series of tumors. (aacrjournals.org)
  • respectively
  • A determination of the circulating levels of 3β-diol in humans found concentrations of 239 ± 76 pg/ml and 82 ± 45 pg/ml of the compound in normal male and female serum, respectively. (wikipedia.org)
  • affinity
  • 3β-Diol has been reported to also bind to ERα with low nanomolar affinity, with several-fold lower affinity relative to ERβ. (wikipedia.org)
  • levels
  • Both ERα and ERβ are differentially expressed in adult prostatic tissues, with the epithelial cells expressing mainly ERβ whereas the stromal cells expressing ERα at low levels ( 3 ). (aacrjournals.org)
  • role
  • Alterations in tumor suppressor genes such as p53 (3 , 4) , pRB (3 , 5) , NOEY2 (6) , BRCA1 (7) , and oncogenes such as K-ras (8) , c-myc (9) and c-erbB-2 (10) have been shown to play an important role in ovarian carcinogenesis. (aacrjournals.org)