• treatment of androgen-dependent skin
  • Flutamide has been researched and used extensively in the treatment of androgen-dependent skin and hair conditions in women including acne, seborrhea, hirsutism, and scalp hair loss, as well as in hyperandrogenism (e.g., in polycystic ovary syndrome or congenital adrenal hyperplasia), and is effective in improving the symptoms of these conditions. (wikipedia.org)
  • Unlike flutamide and nilutamide, the drug is said to be short-acting and inactive by injection, but it has been found to be active topically in animals, and hence could be useful for the treatment of androgen-dependent skin conditions. (wikipedia.org)
  • antiandrogen
  • Spironolactone (Aldactone): An antimineralocorticoid (aldosterone antagonist) with additional/coincidental antiandrogen activity. (wikipedia.org)
  • Cyproterone acetate (abbreviated as CPA), sold alone under the brand name Androcur or with ethinylestradiol (EE) under the brand names Diane or Diane-35 among others, is an antiandrogen and progestogen which is used in the treatment of androgen-dependent conditions like acne, excessive hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender women, and in birth control pills. (wikipedia.org)
  • In the U.S., where CPA is not available, other drugs with antiandrogen properties like the diuretic spironolactone and the progestin medroxyprogesterone acetate are used instead to treat androgen-dependent conditions besides prostate cancer. (wikipedia.org)
  • ligand
  • Non-steroidal compounds which are high affinity, high specificity ligand antagonists for the androgen receptor are disclosed. (patentgenius.com)
  • Metribolone (developmental code name R1881), also known as methyltrienolone, is a synthetic and orally active anabolic-androgenic steroid (AAS) and a 17α-alkylated nandrolone (19-nortestosterone) derivative which was never marketed for medical use but has been widely used in scientific research as a hot ligand in androgen receptor (AR) ligand binding assays (LBAs) and as a photoaffinity label for the AR. (wikipedia.org)
  • estrogen
  • Taking only an anti-androgen incurs risk of serious bone density loss, and taking only estrogen does not significantly lower testosterone levels. (trans-health.com)
  • The drug does not interact with the estrogen receptor, the glucocorticoid receptor, or the mineralocorticoid receptor and hence has no estrogenic, glucocorticoid, or antimineralocorticoid activity. (wikipedia.org)
  • The high-dose formulations are used to treat prostate cancer and certain other androgen-related indications while the low-dose formulations which also have an estrogen are used as combined birth control pills and are used in menopausal hormone therapy for the treatment of menopausal symptoms. (wikipedia.org)
  • precocious puberty
  • Also used for androgen-dependent indications in women and transgender women, precocious puberty in boys, and as a means of chemical castration for sexual deviation in men. (wikipedia.org)
  • CPA is used in the treatment of prostate cancer, precocious puberty, androgen-dependent skin and hair conditions such as acne, seborrhea, hirsutism (excessive hair growth), and androgenic alopecia (pattern hair loss), hyperandrogenism (e.g., in PCOS), and to reduce sex drive in sex offenders or men with paraphilias or hypersexuality. (wikipedia.org)
  • GnRH
  • Although GnRH agonists stimulate the same receptors that GnRH does, since they are present continuously and not in a pulsatile manner, they serve to inhibit the pituitary gland and therefore block the whole chain. (wikipedia.org)
  • In contrast to GnRH agonists, GnRH antagonists don't cause an initial androgen surge, and are gradually replacing GnRH agonists in clinical use. (wikipedia.org)
  • hormones
  • It's a fact that some transsexuals choose-usually because it's the only option available to them-to self-prescribe hormones and/or androgen-blocking drugs. (trans-health.com)
  • indications
  • Used for androgen-dependent indications in women and transgender women, particularly in the United States where cyproterone acetate is unavailable. (wikipedia.org)
  • therapeutic
  • Although there have been recent reports of significant responses with the use of cytotoxic agents in the treatment of castration-resistant disease ( 3 ), there remains an urgent need for new therapeutic strategies in both an adjuvant setting and following failure of androgen ablation therapy. (aacrjournals.org)
  • acne
  • It has some antiandrogenic activity, which may help to improve androgen-dependent symptoms like acne, and has no other important hormonal activity. (wikipedia.org)
  • In fact, it is actually an antagonist of the androgen receptor (AR) and hence has antiandrogenic activity, said to be about 30 to 40% of that of cyproterone acetate, and may be able to improve androgen-dependent symptoms such as acne and hirsutism. (wikipedia.org)