Amobarbital (formerly known as amylobarbitone or sodium amytal as the soluble sodium salt) is a drug that is a barbiturate derivative. (wikipedia.org)
Amobarbital was manufactured by Eli Lilly and Company in the US under the brand name Amytal in bright blue bullet shaped capsules (known as Pulvules) or pink tablets (known as Diskets) containing 50, 100, or 200 milligrams of the drug. (wikipedia.org)
Amytal, as well as Tuinal, a combination drug containing equal quantities of secobarbital and amobarbital, were both manufactured by Eli Lilly until the late-1990s. (wikipedia.org)
Amobarbital was once manufactured in the US by Eli Lilly Pharmaceuticals under the brand name Amytal in capsule form. (wikipedia.org)
Sodium amytal (amobarbital, amylobarbitone, Amytal) is an intermediate-acting barbiturate. (espionageinfo.com)
Intermediate acting barb2
Amobarbital is an intermediate-acting barbiturate with hypnotic properties used in short-term treatment of insomnia and to reduce anxiety and provide sedation preoperatively. (mayocliniclabs.com)
Amobarbital sodium, an intermediate-acting barbiturate, is a CNS depressant. (rxreasoner.com)
Sodium5
Anxiety Epilepsy Insomnia Wada test When given slowly by an intravenous route, sodium amobarbital has a reputation for acting as a so-called truth serum. (wikipedia.org)
In particular, in order to make amobarbital, α-ethyl-α-isoamylmalonic ester is reacted with urea (in the presence of sodium ethoxide). (wikipedia.org)
As with secobarbital sodium and pentobarbital sodium, other barbiturates (including amobarbital) might be expected to lose their effectiveness for inducing and maintaining sleep after about 2 weeks. (rxreasoner.com)
The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital are available as sterile parenteral solutions. (mind42.com)
Sodium amobarbital and effects of frustrative nonreward. (bvsalud.org)
Pentobarbital1
A 1988 study found that amobarbital increases benzodiazepine receptor binding in vivo with less potency than secobarbital and pentobarbital (in descending order), but greater than phenobarbital and barbital (in descending order). (wikipedia.org)
Phenobarbital1
Mezerein (34807415), 12-o-tetradecanoylphorbol-13- acetate (544638), amobarbital (57432), butylated-hydroxytoluene (128370), phenobarbital (50066), butylated-hydroxyanisole (25013165), tryptophan (153946), and catechol (120809) inhibited metabolic cooperation between the wild type and mutant cells. (cdc.gov)
Barbiturates1
Amobarbital (5-ethyl-5-isoamylbarbituric acid), like all barbiturates, is synthesized by reacting malonic acid derivatives with urea derivatives. (wikipedia.org)
Sedative1
Amobarbital is a sedative hypnotic with anticonvulsant properties that interfere with the transmission of impulses from the thalamus to the cortex. (medscape.com)
Hydroxylation1
barbital) It has an LD50 in mice of 212 mg/kg s.c.[citation needed] Amobarbital undergoes both hydroxylation to form 3'-hydroxyamobarbital, and N-glucosidation to form 1-(beta-D-glucopyranosyl)-amobarbital. (wikipedia.org)
Intravenous1
Amobarbital is administered by intravenous infusion or intramuscular injection. (mayocliniclabs.com)
Citation1
citation needed] If amobarbital is taken for extended periods of time, physiological and psychological dependence can develop. (wikipedia.org)
Reduce1
LSD and amobarbital did not reduce the proprioception. (erowid.org)
Function2
Amobarbital has been used in a study to inhibit mitochondrial electron transport in the rat heart in an attempt to preserve mitochondrial function following reperfusion. (wikipedia.org)
Amobarbital did not change the motor function while LSD improved and accelerated motor learning. (erowid.org)
Secobarbital and amobarbital1
According to notes from Kennedy's doctor, Kennedy took secobarbital and amobarbital to help him sleep. (sleepbetter.org)
Wada4
Anxiety Epilepsy Insomnia Wada test When given slowly by an intravenous route, sodium amobarbital has a reputation for acting as a so-called truth serum. (wikipedia.org)
Our aim was to investigate the safety and efficacy of propofol relative to amobarbital in the Wada test. (nih.gov)
These findings support previous studies indicating that propofol is as safe and efficacious as amobarbital, and can continue to be used in Wada procedures with confidence. (nih.gov)
King, D. (1992) Amobarbital effects and lateralized Brain Function - The Wada Test . (bvsalud.org)
Intracarotid1
The duration of the drug effect during the intracarotid amobarbital procedure (IAP) is an important factor when considering the prioritization of behavioral testing during the IAP. (nih.gov)
Injection1
Potential toxic effects of superselective injection of amobarbital sodium on microvasculature: a study in an animal model. (ajnr.org)
Thiopental1
Previous studies of thiopental, a barbiturate similar to sodium amobarbital, found that age and gender significantly affect the dose required to induce anesthesia, such that younger patients require higher dosage. (nih.gov)
Inhibit1
Amobarbital has been used in a study to inhibit mitochondrial electron transport in the rat heart in an attempt to preserve mitochondrial function following reperfusion. (wikipedia.org)
Patients2
To determine if a higher dose of sodium amobarbital was needed for younger patients during the IAP, we analyzed the time to return to preinjection EEG baseline status and time to return to 5/5 strength as a function of patient age and gender. (nih.gov)
The sodium amobarbital effect during IAP dissipates faster in young patients. (nih.gov)
Similar1
Propofol produced similar lateralization rates as amobarbital for both language and memory. (nih.gov)
Results1
Sodium-cyclamate (139059), tryptophan (153946), and amobarbital (57432) showed ambiguous or weakly positive results. (cdc.gov)