• sugar amino acids
  • He is credited with designing new amide-linked molecular entities based on Sugar Amino Acids and anticancer compounds such as amphidinolides, epothilones, crocacins, and clavosolide and the synthesis of glycopeptide antibiotics (vancomycin and teicoplanin) and immunosuppressants (FK506, rapamycin, stevastelins and antascomicin). (wikipedia.org)
  • compounds
  • Given the medicinal and biological significance of the hydroxylated β-amino acids, an increasing volume of research is currently being directed toward regio-, stereo- and enantioselective access to this class of compounds. (ingentaconnect.com)
  • Subcategories of these compounds are cyclic Cα-tetrasubstituted α-amino acids, in which both α-substituents are covalently connected. (uni-regensburg.de)
  • The patents describe various processes for the preparation of this and similar compounds of general formula ##STR2## wherein R 1 is a hydrogen atom or a lower alkyl radical and n is 4, 5, or 6 and the pharmaceutically acceptable salts thereof, which depend upon known methods used for the preparation of primary amines or amino acids. (google.com)
  • The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each denote hydrogen or an organic radical and R4 R5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic. (google.com)
  • The compounds have the general formula (1) wherein R is hydrogen or alkyl (1-3C), R₁ is alkyl (1-3C), alkoxy (1-3C), halogen, hydroxy or esterified hydroxy, amino or acetylated amino, or methylenedioxy, n has the value 0-3, and p is 1 or 2. (google.com)
  • hydrolysis
  • It is named for its ability to catalyze the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides, though a cohesive understanding of its specific physiologic functions are still ambiguous. (wikipedia.org)
  • ester
  • 2. A process according to claim 1 wherein in Step (a) cyclohexanone is reacted with a base at about ambient temperature before reacting it with a phosphonoacetic acid ester. (google.com)
  • 10. A process according to claim 1 wherein the Step (b) the cyclohexylideneacetic acid ester is ethyl cyclohexylideneacetate. (google.com)
  • A biocompatible fluoride receptor has been developed where the interaction between the boronic acid ester and amine (NH) results in fluoride ion selectivity and enhanced fluorescence quenching. (rsc.org)
  • thereof
  • 14. A process according to claim 1 wherein in 1-aminomethyl-1-cyclohexaneacetic acid is converted to a pharmaceutically acceptable acid salt thereof. (google.com)
  • 2. The method of claim 1, wherein N-(1-S-carbethoxy-3-phenyl-propyl)-S-alanyl-1S,3S,5S-2-azabicyclo[3.3.01octane-3-carboxylic acid or a salt thereof is administered. (google.com)
  • novel
  • These novel results indicate activation of pregnancy-associated mechanisms for transport of nutrients into the uterine lumen, and they provide a framework for future studies of nutrients, including glucose, amino acids, and glutathione, required to activate nutrient-sensing cell signaling pathways for growth, development, and survival of conceptuses, as well as for optimization of culture media for in vitro studies of conceptus development. (biomedsearch.com)
  • C(alpha)-tetrasubstituted amino acids are important building blocks in the design and preparation of novel peptidomimetics. (uni-regensburg.de)
  • The instant invention concerns a novel process for the preparation of 1-aminomethyl-1-cyclohexaneacetic acid (gabapentin), a known compound useful for treating certain cerebral diseases such as epilepsy and dizziness. (google.com)
  • tissues
  • Here, we quantify the DLIPS performance using a Raman scattering probe in classification of basic constituents of collagenous tissues, namely, the amino acids glycine, L -proline, and L -alanine, and the dipeptides glycine-glycine, glycine-alanine and glycine-proline and compare the performance to a traditional Raman spectroscopy probe via several multivariate analyses. (spiedigitallibrary.org)
  • whereas
  • CNPase catalyzes the following reaction: nucleoside 2',3'-cyclic phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } nucleoside 2'-phosphate Thus, the two substrates of this enzyme are nucleoside 2',3'-cyclic phosphate and H2O, whereas its product is nucleoside 2'-phosphate. (wikipedia.org)
  • typically
  • Two tyrosines separated by a single amino acid, typically valine or another tyrosine, form a short intra-molecular diphenylether crosslink. (wikipedia.org)
  • reaction
  • For example, gabapentin can be prepared by converting 1,1-cyclohexanediacetic acid, via a reactive acid derivative, into the azide which is subsequently subjected by thermal decomposition to a Curtius reaction. (google.com)
  • Enyne cycloisomerization, an alkyne variant of the Alder-ene reaction (figure 5), is an intramolecular rearrangement of 1,n-enynes to give the corresponding cyclic isomer. (wikipedia.org)
  • amounts
  • however, little is known about changes in the amounts of specific nutrients in the uterine fluids of cyclic and pregnant ruminants. (biomedsearch.com)
  • wherein
  • 12. A process according to claim 1 wherein in step (d) the dilute acid is hydrochloric acid. (google.com)
  • 13. A process according to claim 1 wherein in step (e) an aqueous solution of 1-aminomethyl-1-cyclohexaneacetic acid hydrochloride is passed over a column filled with a weakly basic anion exchanger to afford 1-aminomethyl-1-cyclohexaneacetic acid. (google.com)
  • wherein the second moiety is covalently linked to the linker via a carboxylic acid or a hydroxyl group. (google.nl)
  • 2. The compound of claim 1 , wherein the first moiety is a baclofen, vigabatrin, gabapentin, or pregabalin, or a γ-amino-phosphinic acid derivative. (google.nl)
  • 5. The functionalized support material of claim 4 wherein the mild conditions comprise a treatment selected from the group consisting of exposure to moderate acid, exposure to weak acid, exposure to moderate base, exposure to weak base, photolysis, thiolysis, palladium-catalyzed nucleophilic transfer, rhodium-catalyzed nucleophilic transfer, hydrogenation and fluoridolysis. (google.ca)
  • present invention
  • The present invention is concerned with a process for the preparation of gabapentin (1-aminomethyl-1-cyclohexaneacetic acid). (google.com)
  • Chemical
  • Gabapentin is a generic term used to identify the chemical compound (1-aminomethyl)-1-cyclohexaneacetic acid ##STR1## It is useful in therapy of certain cerebral disorders such as certain forms of epilepsy, faintness attacks, hypokinesia, and cranial traumas. (google.com)
  • gabapentin
  • They also disclose an acid salt, i.e., gabapentin hydrochloride hydrate in a ratio of 4:4:1 and a sodium salt of gabapentin hydrate in a ratio of 2:1. (google.com)
  • The single administration of narcotic analgesics, gamma (γ)-aminobutyric acid (GABA) analogs such as gabapentin, pregabalin and baclofen, antidepressants and non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to display pain alleviating properties in the clinic and in various animal models. (google.nl)
  • known
  • 2',3'-Cyclic-nucleotide 3'-phosphodiesterase also known as CNPase is an enzyme that in humans is encoded by the CNP gene. (wikipedia.org)
  • single
  • It is formed from L-amino acids with the sequence NH2-Glu-Ile-Cys-Ala-Asp-Pro-Lys-Gln-Lys-Trp-Val-Gln-OH (or in single letter code NH2-EICADPKQKWVQ-OH). (wikipedia.org)