• The Amaryllidaceae alkaloids are produced by species of Amaryllidaceae including Narcissus spp. (frontiersin.org)
  • The cytochrome P45O activities of the naturally occurring Amaryllidaceae alkaloid narciclasine (3), isolated from Narcissus pseudonarcissus, and synthetic derivative trans-dihydronarciclasine (5) are reported. (mcmaster.ca)
  • Simultaneous quantitative analysis of biologically important Amaryllidaceae alkaloids in Narcissus tazetta L. subsp. (jrespharm.com)
  • Lycorine, a medicinal plant-derived phenanthridine Amaryllidaceae alkaloid [ 4 ], seems to possess such properties for PCa drug research and development. (oncotarget.com)
  • Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight. (ac.be)
  • Lycorine, a natural alkaloid extracted from the Amaryllidaceae plant family, has been reported to exhibit a wide range of physiological effects, including the potential effect against cancer. (oncotarget.com)
  • DI-fusion Holdings: Lycorine, the main phenanthridine Amaryllidaceae. (ac.be)
  • 6. Li A # , Du Z # , Liao M, Feng Y, Ruan H*, Jiang H.* Discovery and characterisation of lycorine-type alkaloids in Lycoris spp. (tjmu.edu.cn)
  • The bulb contains alkaloids, notably lycorine and crinamine[283]. (pfaf.org)
  • Ridderstjerne is said to contain lycorine and other alkaloids that can be toxic to your dog. (wagwalking.com)
  • Alkaloid Profiling of Galanthus woronowii Losinsk. (jrespharm.com)
  • The alkaloid galanthamine, first isolated from Galanthus woronowii (Amaryllidaceae), is approved by the FDA for the palliative treatment of mild to moderate Alzheimer's disease due to its acetylcholinesterase (AChE) inhibitory activity. (inra.fr)
  • It is important to note that brunsvigias, like all the other genera of Amaryllidaceae, have a very high alkaloid content, and therefore can be extremely toxic. (sanbi.org)
  • Alkaloid Profiling and Cholinesterase Inhibitory Potential of Crinum x amabile Donn. (ub.edu)
  • In conclusion, the results of this first alkaloid profiling of the Rauhia species indicate that R. multiflora is an important natural source of galanthamine-type structures and could be used as a model for the development of biotechnological tools necessary to advance the sustainable production of galanthamine. (inra.fr)
  • Members of the monocot subfamily Amaryllidoideae present a unique type of alkaloids, the norbelladine alkaloids, which are 4-methylcatechol derivatives combined with tyrosine. (wikipedia.org)
  • Main conclusion: Transcriptome analysis of Leucojum aestivum led to the identification of 50 key genes associated with Amaryllidaceae alkaloid biosynthesis including norbelladine synthase which localized in the cytosol and catalyzed norbelladine formation. (tau.ac.il)
  • A toxic alkaloid found in Amanita muscaria (fly fungus) and other fungi of the Inocybe species. (harvard.edu)
  • Obtaining this active pharmaceutical ingredient, still sourced on an industrial scale from the Amaryllidaceae species, is a challenge for pharmaceutical companies due to its low natural yield and the high cost of its synthesis. (inra.fr)
  • The aim of this work was to determine the alkaloid profile of three different Rauhia (Amaryllidaceae) species collected in Peru, and to assess the potential application of their extracts for the treatment of Alzheimer's disease. (inra.fr)
  • Alkaloids extracted from various species of Cinchona. (nih.gov)
  • In the same species, the amount of alkaloids is different in different organs of the plant and, moreover, varies depending on the phase of vegetation and environmental conditions. (medprep.info)
  • Usually, the sum of alkaloids in all Solanaceae species includes both main alkaloids, but in all possible proportions, one of them prevails. (medprep.info)
  • Central to the biosynthesis of the majority of these alkaloids is a C-C phenol-coupling reaction that can have para-para', para-ortho' , or ortho-para' regiospecificity. (frontiersin.org)
  • The discovery of CYP96T1 is of special interest because it catalyzes the first major branch in Amaryllidaceae alkaloid biosynthesis. (frontiersin.org)
  • The limited supply of some Amaryllidaceae alkaloids and diversity of biological activities make the biosynthesis of Amaryllidaceae alkaloids a topic of interest for biotechnology. (frontiersin.org)
  • The diversity of these alkaloids depends on which amino alcohol was formed in the process of biosynthesis from tropane (tropine, scopine or ecgonine) and with what organic acids these amino alcohols subsequently formed esters. (medprep.info)
  • Abstract: The Amaryllidaceae alkaloids (AAs) are a large group of plant specialized metabolites, which are known for their biological activities. (tau.ac.il)
  • Computational experiments were carried out on the activity of the galanthamine-type alkaloids identified in R. multiflora toward five different human AChE structures. (inra.fr)
  • Amaryllidaceae alkaloids are of main interest because of their cholinesterase inhibition potential, which is the main palliative treatment available for this disease. (inra.fr)
  • Thus, this study describes the isolation of the alkaloids of this plant, and their inhibition of the enzymes acetylcholinesterase (eeAChE) and butyrylcholinesterase (eqBuChE), being galanthine the main component. (inra.fr)
  • in the factory isolation of the alkaloid from plants, it is traditionally obtained its inactive racemate - atropine in the form of a salt - Atropini sulfas. (medprep.info)
  • The plant contains alkaloids with fused pyrrolidine and piperidine rings (derivatives of tropine, scopine and ecgonine). (medprep.info)
  • Ridderstjerne belongs to the Amaryllidaceae family and to the genus Hippeastrum spp. (wagwalking.com)
  • Alijevic O, McHugh D, Rufener L, Mazurov A, Hoeng J, Peitsch M ( 2020 ) An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human alpha4beta2 and alpha7 nicotinic acetylcholine receptors. (multichannelsystems.com)
  • The alkaloids were identified by gas chromatography coupled to mass spectrometry (GC-MS), and the AChE inhibitory activity of the extracts was analyzed. (inra.fr)
  • Tests on pure mesembrine hydrochloride substantiated that sunlight and aqueous conditions are required to facilitate this transformation and obtain the active alkaloids.Patnala 2009 This traditional fermentation removes harmful oxalates while retaining the active alkaloids.Smith 1998 In extracts, the alkaloids are more bioavailable across the intestinal, buccal, and mucosal tissues. (proessencekanna.com)
  • Other tropane derivatives, found in the same plants in small quantities, as well as liquid and volatile pyridine derivatives, often associated with tropane alkaloids, are of no practical importance. (medprep.info)
  • Alkaloids from all major structural classes of Amaryllidaceae alkaloids have biological activities. (frontiersin.org)
  • Some of these alkaloids have potential pharmaceutical applications or are already established medicines. (frontiersin.org)
  • Alkaloids are called natural nitrogen-containing compounds of the main character, formed in plants. (medprep.info)
  • Of natural pharmacologically active substances, alkaloids are the main group from which modern medicine draws the largest number of highly effective drugs. (medprep.info)
  • According to world literature, by the end of the past decade, the number of alkaloids isolated from the higher plants of the Earth's flora exceeded 5000. (medprep.info)
  • According to modern concepts, alkaloid-bearing plants make up 10% of the entire world flora. (medprep.info)
  • Mesembrine, a phenylethylamine alkaloid, was first extracted from S. tortuosum in 1898.Smith 1998 It is the major alkaloid found in S. tortuosum, occurring at levels of 0.3% in the leaves and 0.86% in the stems. (proessencekanna.com)
  • Gas chromatography-mass spectroscopy confirms that the unfermented preparation of S. tortuosum contains more alkaloids than the fermented one.Lubbe 2010 Although data are conflicting, reports suggest that activity is only observed when S. tortuosum is fermented, not when it is dried or fresh.Smith 1996 Fermentation causes transformation of mesembrine to delta-7 mesembrenone. (proessencekanna.com)
  • As a further synthetic application, a stereoselective synthesis of 5,11-methanomorphanthridin-3-one, which shares a key skeleton with montanine-type Amaryllidaceae alkaloids has been achieved by using this chemistry. (researcher-app.com)
  • Furthermore, the diastereoselective synthesis of the framework of montanine-type Amaryllidaceae alkaloids has also been explored by using this chemistry. (researcher-app.com)
  • Within this study, we have generated a pilot series of compounds (1-20) structurally inspired from belladine-type Amaryllidaceae alkaloids, namely carltonine A and B, and evaluated their acetylcholinesterase (AChE) and BuChE inhibition properties. (inrae.fr)
  • Specific examples of alkaloids derived from (10b R ,4a S )-noroxomaritidine include haemanthamine, maritidine, vittatine, and pretazettine. (frontiersin.org)
  • This study provides an Amaryllidaceae transcriptome that will be very helpful to identify genes for characterization studies in AA metabolism in planta or using heterologous systems. (tau.ac.il)
  • Tropine in nightshades is esterified with tropic acid to form the alkaloid hyoscyamine. (medprep.info)