• ADCs
  • Amanitin-based ADCs have shown outstanding activity in therapy-resistant tumor cells, e.g. cells expressing multi-drug resistant transporters, tumor-initiating cells and non-dividing cells at picomolar concentrations. (wikipedia.org)
  • Examples
  • Examples include: Amanitins Bacitracin Colistin Ciclosporin Dactinomycin Daptomycin Gramicidin S Hymenistatin Microcystins Nisin Nodularin Octreotide Polymyxin B Pristinamycin Valinomycin (technically a depsipeptide) Vancomycin Viscumamide Yunnanin A Nonribosomal peptide lantibiotics, 19-37 residues and 1 to 5 'bridges' Jensen, Knud (2009-09-01). (wikipedia.org)
  • presence
  • Over expression of transcripts by IVM oocytes is particularly interesting, therefore, a variety of approaches were employed to determine whether the observed transcriptional changes during IVM were real or an artifact of the techniques used during analysis, including the analysis of transcript abundance in oocytes in vitro matured in the presence of α-amanitin. (springer.com)
  • symptoms
  • it is not unusual for significant effects to take as long as 24 hours after ingestion to appear, with this delay in symptoms making α-amanitin poisoning even more difficult to diagnose and all the more dangerous. (wikipedia.org)
  • technology
  • Heidelberg Pharma, GmbH, based in Ladenburg, Germany, a pharmaceutical company providing pre-clinical drug discovery and development services, has developed a new antibody-drug conjugate or ADC technology based on α-amanitin. (wikipedia.org)
  • The technology platform includes Amanitin supply, site-specific conjugation, demonstrated safety profile and biomarker. (smi-online.co.uk)
  • skin
  • If β-amanitin comes in contact with skin, it may cause irritation, burns, redness, severe pain, and could be absorbed through the skin, causing similar effects to exposure via inhalation and ingestion. (wikipedia.org)
  • addition
  • The addition of α-amanitin can reduce the rate of pol II translocating on DNA from several thousand to a few nucleotides per minute, but has little effect on the affinity of pol II for nucleoside triphosphate, and a phosphodiester bond can still be formed. (wikipedia.org)