• selective
  • describe the Q pocket as subdivided into 3 parts:A saddle formed by the conserved glutamine (Q817 in PDE5A, Q443 in PDE4B and Q369 in PDE4D) and the P clamp (a hydrophopic clamp at the narrow side of the active sites pocket, formed of invariant purine-selective glutamine and a pair of conserved residues). (wikipedia.org)
  • mutation
  • By contrast, the D-loop of the consensus site is flexible and the aspartate to alanine mutation and conformational restriction by cross-linking strongly reduces ATP hydrolysis and substrate transport. (uzh.ch)
  • Residues
  • The allosteric site, which binds ADP, consists of amino acid residues from three subunits. (wikipedia.org)
  • Other residues of RNR2, such as aspartate (D273), tryptophan (W48), and tyrosine (Y356) further stabilize the active-site tyrosyl radical thus allowing electron transfer. (wikipedia.org)
  • Site-directed mutations of the RNR primary structure indicate that all residues cited above participate in the long distance transfer of the free radical to the active site. (wikipedia.org)
  • and cysteine (C838 and C841) residues that are used in the regeneration of dithiol groups in the active site. (wikipedia.org)
  • The active site is a deep pocket at the junction of the 3 subdomains and is lined with highly conserved residues between isotypes of PDE. (wikipedia.org)
  • bound
  • Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase. (thefreedictionary.com)
  • Here, we present the apo structure of the heterodimeric ABC exporter TM287/288 and compare it to the previously solved structure with adenosine 5'-(β,γ-imido)triphosphate (AMP-PNP) bound at the degenerate site. (uzh.ch)
  • Under resting conditions, it is thought that chloride is bound to allosteric sites in prestin. (wikipedia.org)
  • ligand
  • Binding occurs as a result of non-covalent interactions between the receptor and its ligand, at locations called the binding site on the receptor. (wikipedia.org)
  • targets
  • To assist in the identification of propofol targets and binding sites, photoactive analogs that retain anesthetic efficacy have been developed by our group and others ( 7 , - 10 ). (pubmedcentralcanada.ca)
  • Because epimerox targets the allosteric site of the bacterial 2-epimerase, low human toxicity is expected since the human 2-epimerase does not have this site. (wikipedia.org)
  • consists
  • The active site consists of the active dithiol groups from the RNR1 as well as the diferric center and the tyrosyl radical from the RNR2 subunit. (wikipedia.org)
  • aspartate
  • The D-loop at the degenerate site ties the NBDs together even in the absence of nucleotides and substitution of its aspartate by alanine is well-tolerated. (uzh.ch)
  • different
  • Just how many different small-molecule binding sites are there? (sciencemag.org)
  • Even if those binding sites were completely different from one another , we'd be looking at a set of binding pockets in the thousands/tens of thousands range, most likely. (sciencemag.org)
  • effects
  • The models are valid in pharmacology, enzymology, transportology as well as several other fields of biology involving allosteric concentration effects. (biomedsearch.com)
  • Structural
  • Nucleotide binding at the degenerate site results in structural rearrangements, which are transmitted to the consensus site via two D-loops located at the NBD interface. (uzh.ch)
  • Results
  • RESULTS: I show here that Hall's model for interactions between an orthoster, an alloster, and a receptive unit is the best choice of model both for simulation and analysis of allosteric concentration-responses at equilibrium or steady-state. (biomedsearch.com)