Effects of remifentanil and alfentanil on the cardiovascular responses to induction of anaesthesia and tracheal intubation in the elderly. (druglib.com)
BACKGROUND: We compared the effects of remifentanil and alfentanil on arterial pressure and heart rate at induction of anaesthesia and tracheal intubation in 40 ASA I-III patients aged greater than 65 yr, in a randomized double-blind study. (druglib.com)
The aim of this study was to contrast the pharmacokinetics and pharmacodynamics of remifentanil and alfentanil in healthy, adult male volunteers. (silverchair.com)
Ten volunteers received infusions of remifentanil and alfentanil on separate study sessions using a randomized, open-label crossover design. (silverchair.com)
Propofol5
METHODS: Patients received either remifentanil 0.5 microg kg(-1) over 30 s, followed by an infusion of 0.1 microg kg min(-1) (group R) or alfentanil 10 microg kg(-1) over 30 s, followed by an infusion of saline (group A). Anaesthesia was then induced with propofol, rocuronium, and 1% isoflurane with 66% nitrous oxide in oxygen. (druglib.com)
Background: Alfentanil in combination with propofol produces a synergistic sedative effect in patients undergoing flexible bronchoscopy (FB). (tmu.edu.tw)
The aim of this study was to evaluate the proper induction regimen of alfentanil in propofol target-controlled infusion for FB sedation. (tmu.edu.tw)
Conclusion: Alfentanil 5mg/kg given immediately before propofol infusion cannot be recommended. (tmu.edu.tw)
Effect of methohexitone and propofol with or without alfentanil on seizure duration and recovery in electroconvulsive therapy. (rochester.edu)
Micrograms1
Alfentanil (20 micrograms/kg bolus) was administered to nine nonsmoking, nonpregnant female volunteers (age, 26 +/- 5 yr) with normal menstrual cycles on three separate occasions during the same menstrual cycle: days 2 (menstrual phase), 13 (estrogen peak), and 21 (progesterone peak). (asahq.org)
Conclusions1
Further study is required to define conclusions about alfentanil 2.5 and 5mg/kg because of the low power rating of subgroup in the present study. (tmu.edu.tw)
Infusion1
Compared to alfentanil, the high clearance of remifentanil, combined with its small steady-state distribution volume, results in a rapid decline in blood concentration after termination of an infusion. (silverchair.com)
Methods1
Alfentanil clearance was determined by noncompartmental methods and by a three-compartment model with both pooled population and two-stage analysis. (asahq.org)
Medicine1
Rapifen contains a medicine called alfentanil hydrochloride. (medicalbrandnames.com)
Clearance2
Alfentanil clearance was used as a metabolic probe for P450 3A4 activity. (asahq.org)
There was no significant difference in any measure of alfentanil clearance. (asahq.org)
Plasma2
With the exception of remifentanil's nearly 20-times greater potency (30-times if alfentanil partitioning between whole blood and plasma is considered), the drugs are pharmacodynamically similar. (silverchair.com)
Pharmacodynamically, the drugs are similar in terms of the time required for equilibration between blood and the effect-site concentrations, as evidenced by a T(12)k(e0) for remifentanil of 0.75 min [corrected] and 0.96 min for alfentanil. (silverchair.com)
However, remifentanil is 19 times more potent than alfentanil, with an effective concentration for 50% maximal effect of 19.9 ng x ml(-1) versus 375.9 ng x ml(-1) for alfentanil. (silverchair.com)
Alfenta1
Alfentanil (R-39209, trade name Alfenta, Rapifen in Australia) is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery. (wikipedia.org)
In this study, the authors examined whether other opioids of importance to anesthesiologists such as fentanyl, sufentanil, and alfentanil, and also morphine-6-glucuronide and morphine-3-glucuronide, are P-glycoprotein substrates and whether, in turn, these opioids act also as P-glycoprotein inhibitors. (nih.gov)
Analgesic3
Avoid use with Alfentanil HCl Injection because they may reduce analgesic effect of Alfentanil HCl Injection or precipitate withdrawal symptoms. (nih.gov)
In this study, the anaesthetic effects and reliability of the combination of etomidate, which is a non-barbiturate injectable anaesthetic, and alfentanil, which is a strong narcotic analgesic, in anaesthesia induction in dogs were investigated. (tubitak.gov.tr)
Once the mother's milk comes in, it is best to provide pain control with a nonnarcotic analgesic and limit maternal intake of alfentanil to a few days with careful monitoring. (nih.gov)
Fentanyl2
While alfentanil tends to cause fewer cardiovascular complications than other similar drugs such as fentanyl and remifentanil, it tends to give stronger respiratory depression and so requires careful monitoring of breathing and vital signs. (wikipedia.org)
Induction of anesthesia is accomplished by using high doses of opioid (usually fentanyl or alfentanil) to maximize cardiovascular stability. (medscape.com)
Alfentanil Injection, USP contains alfentanil, an opioid agonist, chemically designated as N- [1- [2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1- yl) ethyl]-4-(methoxymethyl)-4-piperidinyl]-N-phenylpropanamide. (pfizermedicalinformation.com)
Intravenous4
Alfentanil HCl Injection should be administered only by persons specifically trained in the use of intravenous anesthetics and management of the respiratory effects of potent opioids. (nih.gov)
however, because there is no published experience with repeated doses of intravenous alfentanil during established lactation, other agents may be preferred, especially while nursing a newborn or preterm infant. (nih.gov)
Nine women in the early postpartum period were given intravenous alfentanil 50 mcg initially and then 10 mcg as needed during tubal ligation surgery under general anesthesia. (nih.gov)
Alfentanil Injection USP, for intravenous use (equivalent to 500 mcg/mL alfentanil base). (pfizermedicalinformation.com)
Doses1
Doses of Alfentanil HCl Injection vary depending on circumstances (see dosing chart, 2.2 . (nih.gov)
Morphine2
Objective -To evaluate and compare effects of epidurally administered morphine, alfentanil, butorphanol, tramadol, and U50488H on avoidance threshold to noxious electrical stimulation over the dermatomes of the perineal, sacral, lumbar, and thoracic regions in horses. (avma.org)
Procedure -Using a Latin square complete repeatedmeasures design, horses were randomly assigned to receive 1 of 6 treatments (morphine, alfentanil, butorphanol, tramadol, U50488H, or sterile water) at intervals of at least 7 days. (avma.org)
Anesthesia5
Almost exclusively used by anesthesia providers during portions of a case where quick, fast-acting (though not long-lasting) pain control is needed (as, for example, during nerve blocks), alfentanil is administered by the parenteral (injected) route for fast onset and precise control of dosage. (wikipedia.org)
Mets, B 1991, ' Acute dystonia after alfentanil in untreated Parkinson's disease ', Anesthesia and analgesia , vol. 72, no. 4, pp. 557-558. (psu.edu)
A total of 204 patients scheduled for day surgery of cold knife cervical conization received either remimazolam-alfentanil anesthesia (remimazolam group) or propofol-alfentanil anesthesia (propofol group). (bvsalud.org)
The occurrence of hypotension, bradycardia, hypoxemia and the degree of body movement were secondary outcomes, as well as the moment at which consciousness was lost, the interval between the end of anesthesia and the operating room's release of the patient, and the overall dosage of alfentanil administered during the procedure. (bvsalud.org)
Conclusion: In patients who underwent cold knife cervical conization, remimazolam-alfentanil anesthesia was associated with a reduced incidence of intraoperative cardiopulmonary adverse events compared with propofol-alfentanil anesthesia. (bvsalud.org)
Dose2
Reduce the dose of Alfentanil HCl Injection when administered with CNS depressants. (nih.gov)
Following tranquillisation, etomidate at a dose of 2mg/kg and alfentanil at a dose of 0.02mg/kg were injected intravenously. (tubitak.gov.tr)
Propofol4
Should Propofol and Alfentanil Be Combined in Patient-Controlled Sedation? (scirp.org)
The objective of this study was to compare the safety and efficacy profiles of the remimazolam and propofol when combined with alfentanil for sedation during ERCP procedures. (bvsalud.org)
INTERVENTIONS: Patients scheduled for ERCP were randomly assigned to be sedated with either a combination of remimazolam-alfentanil or propofol-alfentanil. (bvsalud.org)
CONCLUSION: During elective ERCP, patients administered with remimazolam showed fewer respiratory depression events under deep sedation with hemodynamic advantages over propofol when administered in combination with alfentanil. (bvsalud.org)
MISUSE1
Alfentanil HCl injection exposes users to risks of addiction, abuse, and misuse, which can lead to overdose and death. (nih.gov)
Infants2
When used epidurally or intravenously during labor or for a short time immediately postpartum, amounts of alfentanil ingested by the neonate are small and would not be expected to cause any adverse effects in breastfed infants. (nih.gov)
Alfentanil as procedural pain relief in newborn infants. (bmj.com)
Injection7
These highlights do not include all the information needed to use ALFENTANIL HCl INJECTION safely and effectively. (nih.gov)
See full prescribing information for ALFENTANIL HCl INJECTION. (nih.gov)
Discontinue Alfentanil HCl Injection if serotonin syndrome is suspected. (nih.gov)
Alfentanil Injection should be administered only by persons specifically trained in. (pfizermedicalinformation.com)
Acute overdose with Alfentanil Injection can be manifested by respiratory depression, somnolence. (pfizermedicalinformation.com)
Dosage2
however, average cumulative alfentanil dosage was not reported. (nih.gov)
1] Using the highest measured alfentanil level in this study, an exclusively breastfed infant would receive an alfentanil dosage of 0.2 mcg/kg daily. (nih.gov)
Systemic2
There is considerable unexplained variability in alfentanil pharmacokinetics, particularly systemic clearance. (asahq.org)
Alfentanil is extensively metabolized in vivo, and thus systemic clearance depends on hepatic biotransformation. (asahq.org)
Dogs1
Etomidate/Alfentanil Anaesthesia in Dogs and Its Effects on Pulse Oxym" by E. CEM PERK, ÖZLEM GÜZEL et al. (tubitak.gov.tr)
Movement1
No significant differences were observed in the overall alfentanil dosages administered, bradycardia, bodily movement, or time to losing consciousness between the two groups. (bvsalud.org)
Drug2
Alfentanil has a pKa of approximately 6.5, which leads to a very high proportion of the drug being uncharged at physiologic pH, a characteristic responsible for its rapid onset. (wikipedia.org)
Discovered at Janssen Pharmaceutica in 1976, alfentanil is classified as a Schedule II drug in the United States. (wikipedia.org)
Primary1
Venous blood was sampled for 24 h and plasma concentrations of midazolam and alfentanil and their primary metabolites 1'-hydroxymidazolam and noralfentanil were measured by gas chromatography-mass spectrometry. (asahq.org)