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  • excess
  • Recent research has shown that excess aldosterone production can also be associated with obesity and the development of related diseases such as insulin resistance and diabetes. (prweb.com)
  • By proving the principle that the oversecretion of aldosterone can be specifically blunted in APA cells ex vivo with G151R and L168R mutations, these results provide compelling evidence of the possibility of specifically correcting aldosterone excess in patients with APA carrying the 2 most common KCNJ5 somatic mutations. (ahajournals.org)
  • synthase
  • These enzymes are nearly identical (they share 11β-hydroxylation and 18-hydroxylation functions), but aldosterone synthase is also able to perform an 18- oxidation . (wikipedia.org)
  • aldosterone synthase is absent in other sections of the adrenal gland . (wikipedia.org)
  • Aldosterone synthase is encoded on chromosome 8q22 by the CYP11B2 gene. (wikipedia.org)
  • Aldosterone synthase is a member of the cytochrome P450 superfamily of enzymes. (wikipedia.org)
  • In the potential case where aldosterone synthase is not metabolically active the body accumulates 11-deoxycorticosterone. (wikipedia.org)
  • The in-active proteins are caused by the autosomal recessive inheritance of defective CYP11B2 genes in which genetic mutations destroy the enzymatic activity of aldosterone synthase. (wikipedia.org)
  • Ongoing medical research is focusing on the synthesis of second-generation aldosterone synthase inhibitors to create an ideally selective inhibitor as the current, orally delivered, LCl699 has shown to be non-specific to aldosterone synthase. (wikipedia.org)
  • synthesis
  • Steroidogenesis , showing aldosterone synthesis at upper-right corner. (wikipedia.org)
  • Cholesterol is metabolized in what is known as the early pathway of aldosterone synthesis and is hydroxylated becoming (20R,22R)-dihydroxycholesterol which is then metabolized as a direct precursor to pregnenolone. (wikipedia.org)
  • binds
  • Aldosterone enters a target cell and binds MR, which translocates into the nucleus and regulates gene transcription. (genome.jp)
  • GPER, also known as GPR30, binds and is activated by aldosterone, and may be considered an mMR, although it also binds and is activated by estradiol and is generally described as a membrane estrogen receptor (mER). (wikipedia.org)
  • inhibitor
  • The inability of ACE inhibitor therapy to reliably suppress aldosterone release, for example, in patients with heart failure or diabetes, usually manifested by increased salt and water retention. (wikipedia.org)
  • antagonists
  • What are aldosterone antagonists? (simstat.com)
  • Aldosterone antagonists (or aldosterone blockers) are a class of medications used to treat high blood pressure and heart failure. (simstat.com)
  • Aldosterone antagonists are not routine therapy for women with heart failure because they are less proven than other medications in the same class, including ACE inhibitors and ARBs. (simstat.com)
  • Who should receive aldosterone antagonists to prevent or treat heart failure? (simstat.com)
  • In women at high risk for heart failure but who do not yet have damage to the heart (Stage A heart failure), aldosterone antagonists can be used to treat high blood pressure. (simstat.com)
  • Who should NOT receive aldosterone antagonists? (simstat.com)
  • Aldosterone antagonists are not routine therapy for women with systolic heart failure , but are used in selected patients who have recently had a heart attack or who have severe symptoms. (simstat.com)
  • Also talk to your doctor if you are taking any medications to treat a fungal infection, because some of these drugs can have dangerous interactions with aldosterone antagonists. (simstat.com)
  • Do aldosterone antagonists work as well in women as in men? (simstat.com)
  • Our knowledge about which heart failure patients benefit from treatment with aldosterone antagonists comes from a few large, well-controlled studies. (simstat.com)
  • Furthermore, aldosterone is known to exert several detrimental effects on the vasculature, some of which are offset by mineralocorticoid receptor antagonists. (clinicaltrials.gov)
  • underproduction
  • Hypoaldosteronism (the syndrome caused by underproduction of aldosterone) leads to the salt-wasting state associated with Addison's disease, although classical congenital adrenal hyperplasia and other disease states may also cause this situation. (wikipedia.org)
  • salivary
  • Salimetrics' list of measurable biomarkers in saliva has expanded once again with the addition of an assay for salivary aldosterone. (prweb.com)
  • blood
  • 1,2) Like the other steroid hormones that can be measured in saliva, aldosterone diffuses readily from the circulation into saliva where it can be conveniently measured without the pain and inconvenience of drawing blood samples. (prweb.com)
  • Your brain interprets these signals and sends messages to your adrenal glands, which then alter their release of hormones - epinephrine, norepinephrine and aldosterone - that control your heart rate, blood vessel diameter and kidney function. (livestrong.com)
  • Aldosterone also helps drive-up your blood pressure. (medhelp.org)
  • In women who have recently had a heart attack and have a systolic heart failure(blood pumping problems) that is causing symptoms, adding the aldosterone antagonist eplerenone to standard treatment reduces hospitalization and improves survival. (simstat.com)
  • levels
  • Researchers can now easily and non-invasively measure aldosterone levels in conjunction with other key biomarkers that are found in saliva, which will benefit those who are studying cardiovascular disease, obesity, diabetes, kidney disease, and psychiatric conditions. (prweb.com)
  • Is there some kind of direct correlation between untreated hypothyroidism (mine has been pretty much untreated for years) and high or fluctuating aldosterone levels? (medhelp.org)
  • yo-yo aldosterone levels Hi, I was officially diagnosed with hypothyroid about 18 months ago but couldn't tolerate the natural dessicated meds (Armour). (medhelp.org)
  • This is the proposed mechanism of "mineralocorticoid escape" for how patients with increased levels of aldosterone are able to maintain Na+ balance and avoid an edematous state. (wikipedia.org)