• timolol
  • It is a combination of brimonidine (an α2 adrenergic agonist) and timolol (a β adrenergic blocker), in concentrations of 0.2% and 0.5% respectively. (wikipedia.org)
  • Although clinical studies showed that the IOP-lowering effect was slightly greater (1-2 mmHg) with concomitant administration of 0.5% timolol twice daily and 0.2% brimonidine tartrate three times daily than with Combigan twice daily, the safety profile of latter was more favorable. (wikipedia.org)
  • activation
  • It is postulated that general anaesthetics exert their action by the activation of inhibitory central nervous system (CNS) receptors, and the inactivation of CNS excitatory receptors. (wikipedia.org)
  • Other effects on smooth muscle are contraction in: Ureter Uterus (when pregnant) Urethral sphincter Bronchioles (although minor to the relaxing effect of β2 receptor on bronchioles) Iris dilator muscle Seminal tract, resulting in ejaculation Activation of α1-adrenergic receptors produces anorexia and partially mediates the efficacy of appetite suppressants like phenylpropanolamine and amphetamine in the treatment of obesity. (wikipedia.org)
  • neurons
  • Below are several key targets of general anesthetics that likely mediate their effects: GABAA receptors are chloride channels that hyperpolarize neurons and function as inhibitory CNS receptors. (wikipedia.org)
  • for example, α2A receptors are localized on prefrontal cortical neurons where they regulate higher cognitive function. (wikipedia.org)
  • blockers
  • When methyldopa was first introduced, it was the mainstay of antihypertensive treatment, but its use has declined on account of relatively severe adverse side effects, with increased use of other safer and more tolerable agents such as alpha blockers, beta blockers, and calcium channel blockers. (wikipedia.org)
  • α Adrenergic agonists have the opposite function of alpha blockers. (wikipedia.org)
  • guanfacine
  • This is an extension study that will allow participants access to Extended-release Guanfacine Hydrochloride (HCl) for up to 2 years. (clinicaltrials.gov)
  • Prior failed treatment with an adequate trial of guanfacine in last 2 years. (clinicaltrials.gov)
  • increases
  • In the normal eye, beta-2 stimulation by salbutamol increases intraocular pressure via net: Increase in production of aqueous humour by the ciliary process, Subsequent increased pressure-dependent uveoscleral outflow of humour, despite reduced drainage of humour via the Canal of Schlemm. (wikipedia.org)
  • doses
  • Lofexidine HCl 0.2 mg tablets titrated in ascending doses of 0.2 mg (1 tablet) QID starting at 0.4 mg (2 tablets) QID [e.g. (clinicaltrials.gov)
  • Methadone maintained subjects will be titrated on placebo tablets in ascending doses of 1 tablet starting with 2 tablets (e.g. (clinicaltrials.gov)
  • cardiac
  • Contraindications of Combigan include the following: reactive airway disease including bronchial asthma, a history of bronchial asthma, severe chronic obstructive pulmonary disease, sinus bradycardia, secondary or third degree atrioventricular block, overt cardiac failure, cardiogenic shock, age less than 2 years, and hypersensitivity to any component of Combigan. (wikipedia.org)
  • Actions of the β2 receptor include: Heart muscle contraction increase cardiac output (minor degree compared to β1). (wikipedia.org)