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  • Primary pigmented nodular adrenocortical disease (PPNAD) is a pituitary-independent, primary adrenal form of hypercortisolism characterized by (a) resistance to suppression by dexamethasone and abolition of the normal diurnal rhythm of cortisol secretion, and (b) distinctive, bilateral, histopathologic changes of the adrenal glands, such as the formation of variably sized, pigmented nodular adenomas, loss of normal zonation and atrophy of the extranodular cortex. (clinicaltrials.gov)
  • levels
  • Other side effects of Korlym include adrenal insufficiency, low potassium levels, vaginal bleeding and a potential for heart conduction abnormalities. (healthcanal.com)
  • growth
  • PPNAD can be associated with tumors (myxomas) of the skin, heart, breast, tumors (swannomas) of the nerve sheaths, pigmented spots (nevi and lentigines) of the skin, growth hormone (GH) producing tumors of the pituitary gland, and tumors of the testicles, ovaries, and thyroid gland. (clinicaltrials.gov)
  • atrophy
  • Amphenone B was first synthesized in 1950 and is a diphenylmethane derivative that was derived from the insecticide 2,2-di(p-chlorophenyl)-1,1-dichloroethane (p,p'-DDD), which in 1949 had been found to selectively induce adrenal atrophy. (wikipedia.org)
  • Addison's Disease
  • Fifty years later, a Guy's Hospital physician, Thomas Addison, showed that the adrenal glands were necessary for life, by identifying them as the site of damage in a previously mysterious and ultimately fatal illness, which became known as Addison's disease. (encyclopedia.com)
  • The second condition which is typically linked to adrenal gland tumors is known as Addison's Disease. (vetinfo.com)
  • mammary glands
  • Conversely, the progesterone-like effects of amphenone B on the mammary glands were found to persist even in adrenalectomized and ovariectomized animals. (wikipedia.org)
  • Oxytocin: secreted from the posterior pituitary and acts on the uterus and mammary glands to produce contractions. (wikipedia.org)
  • thyroid
  • Thyroid-stimulating hormone (TSH) promotes normal development and activity of the thyroid gland. (wikipedia.org)
  • The thyroid gland is located at the front of the neck, in front of the thyroid cartilage, and is shaped like a butterfly, with two wings connected by a central isthmus. (wikipedia.org)
  • Calcitonin, produced by the parafollicular cells of the thyroid gland in response to rising blood calcium levels, depresses blood calcium levels by inhibiting bone matrix resorption and enhancing calcium deposit in bone. (wikipedia.org)
  • Amphenone B, or simply amphenone, also known as 3,3-bis(p-aminophenyl)butan-2-one, is an inhibitor of steroid hormone and thyroid hormone biosynthesis which was never marketed but has been used as a tool in scientific research to study corticosteroids and the adrenal glands. (wikipedia.org)
  • In addition, amphenone B inhibits the production of thyroxine by a thiouracil-like mechanism, specifically via inhibition of organic binding of iodine and uptake of iodide by the thyroid gland. (wikipedia.org)
  • hormone
  • Diagnosis for adrenal cancer usually begins with blood tests to evaluate the hormone levels. (encyclopedia.com)
  • in the case of this condition, your pet's adrenal glands produce a quantity of hormone that is too low for your pet's system. (vetinfo.com)
  • If your pet's glands produce too much of a particular hormone, medicines that inhibit his body from fully processing those hormones can also be helpful in removing his adrenal gland problems. (vetinfo.com)
  • Overactive adrenal glands occur when the body has been exposed to excess amounts of the hormone cortisol for an extended period of time. (ehow.co.uk)
  • The adrenal glands contribute about 7% of circulating norepinephrine, most of which is a spill over from neurotransmission with little activity as a hormone. (wikipedia.org)
  • androgens
  • Adrenal virilism is the development or premature development of male secondary sexual characteristics caused by male sex hormones ( androgens ) excessively produced by the adrenal gland . (factbites.com)
  • The adrenal cortex produces mineralocorticoids, which regulate salt and water balance within the body, glucocorticoids (including cortisol) which have a wide number of roles within the body, and androgens, hormones with testosterone-like function. (wikipedia.org)
  • DHEA and other adrenal androgens such as androstenedione, although relatively weak androgens, are responsible for the androgenic effects of adrenarche, such as early pubic and axillary hair growth, adult-type body odor, increased oiliness of hair and skin, and mild acne. (wikipedia.org)
  • gonads
  • It is one of the most abundant circulating steroids in humans, in whom it is produced in the adrenal glands, the gonads, and the brain, where it functions as a metabolic intermediate in the biosynthesis of the androgen and estrogen sex steroids. (wikipedia.org)
  • Diabetes
  • A cancer that arises in the adrenal cortex is called an adrenocortical carcinoma and can produce high blood pressure , weight gain, excess body hair, weakening of the bones and diabetes. (encyclopedia.com)
  • sympathetic
  • It is called a "sympathetic" gland because it responds to external stimuli, such as anxiety with the so-called "fight or flight" instinct. (wisegeek.com)
  • Both tumors may also arise from extra-adrenal sites, specifically, in the paraganglia of the sympathetic chain. (wikipedia.org)
  • chromaffin
  • It was developed in parallel to the adrenal chromaffin cell model because of its extreme versatility for pharmacological manipulation, ease of culture, and the large amount of information on their proliferation and differentiation. (wikipedia.org)
  • tissue
  • A variety of tumors can arise from adrenal tissue and are commonly found in medical imaging when searching for other diseases. (wikipedia.org)
  • Cells in this layer form oval groups, separated by thin strands of connective tissue from the fibrous capsule of the gland and carry wide capillaries . (wikipedia.org)
  • The adrenal gland regulates these and other substances via certain layers of tissue all of which operate according to the type of cells that handle those chemicals. (wizzley.com)
  • A variety of tumors can arise from adrenal tissue and are commonly found in medical imaging when searching for other diseases. (wikipedia.org)
  • especially
  • Steroid precursors up to and including progesterone, 17α-hydroxypregnenolone, and especially 17α-hydroxyprogesterone accumulate in the adrenal cortex and in circulating blood. (wikipedia.org)