• Oral, subcutaneous, and intranasal delivery are perhaps the most practical methods. (psychiatrist.com)
  • From the point of view of clinical practicability, subcutaneous, intranasal, and oral ketamine warrant further study. (psychiatrist.com)
  • To determine the effectiveness of intranasal (IN) naloxone compared with intramuscular (IM) naloxone for treatment of respiratory depression due to suspected opiate overdose in the prehospital setting. (mja.com.au)
  • Ocular antihistamine drops (for eye symptoms), intranasal antihistamine sprays, intranasal cromolyn, intranasal anticholinergic sprays, and short courses of oral corticosteroids (reserved for severe, acute episodes only) may also provide relief. (medscape.com)
  • Administration involves a series of actions: assessing patient vaccination status and determining needed vaccines, screening for contraindications and precautions, educating patients, preparing and administering vaccines properly, and documenting the vaccines administered. (cdc.gov)
  • In addition, health care professionals should receive educational updates as needed, such as when vaccine administration recommendations are updated or when new vaccines are added to the facility's inventory. (cdc.gov)
  • To compare the clinical efficacy of two routes of midazolam intranasal vs. intravenous, in relation to intravenous diazepam for control of seizures. (pediatriconcall.com)
  • Group-I was given intranasal midazolam at 0.3 mg /kg, Group-II was given intravenous midazolam at 0.3mg/kg and Group-III was given intravenous diazepam at 0.3 mg /kg. (pediatriconcall.com)
  • Mean time from physician contact to drug administration was significantly shorter with intranasal midazolam as compared to intravenous midazolam and intravenous diazepam (0.40±0.10min vs. 1.06±0.40 min and 1.06±40 min) (p-0.03). (pediatriconcall.com)
  • We conducted this study to evaluate the efficacy of intranasal midazolam vs. intravenous midazolam and intravenous diazepam in convulsing neonates and children. (pediatriconcall.com)
  • Glucagon may be useful when intravenous (IV) access for dextrose administration is problematic. (medscape.com)
  • 0.05, n=4) in comparison to saline treated controls, demonstrating our intranasal delivery system's efficacy. (nih.gov)
  • Previous studies evaluated the efficacy of delivery therapeutics through intranasal route for brain diseases and mental health conditions. (wikipedia.org)
  • There is evidence for the efficacy of intranasal delivery to treat Alzheimer's. (wikipedia.org)
  • A preclinical efficacy service provide with proven track record of intranasal delivery is needed to support the program. (scanbalt.org)
  • Intranasal administration is a potential route associated with high drug transfer from nose to brain and drug bioavailability. (wikipedia.org)
  • The delivery systems between neutral to acidic pH is ideal for high drug bioavailability following intranasal administration. (wikipedia.org)
  • The area under the curve of optimized formulation (F2) was 3.98 and 1.53 times more than oral drug solution and intranasal gel respectively, confirming improvement in bioavailability. (ijpsonline.com)
  • AdCOVID is a single-dose COVID-19 vaccine candidate that has the potential to be conveniently administered via an intranasal spray. (yahoo.com)
  • NEW YORK--(BUSINESS WIRE)-- Pfizer Inc. (NYSE: PFE) today announced the U.S. Food and Drug Administration (FDA) has approved ZAVZPRET™ (zavegepant), the first and only calcitonin gene-related peptide (CGRP) receptor antagonist nasal spray for the acute treatment of migraine with or without aura in adults. (pfizer.com)
  • For intranasal use only, the recommended dose is 1 spray per nostril twice daily in adults and adolescents 12 years of age and older. (rxlist.com)
  • Dymista (azelastine hydrochloride and fluticasone propionate) nasal spray is formulated as a white, uniform metered-spray suspension for intranasal administration. (rxlist.com)
  • After priming [see DOSAGE AND ADMINISTRATION ], each metered spray delivers a 0.137 mL mean volume of suspension containing 137 mcg of azelastine hydrochloride (equivalent to 125 mcg of azelastine base) and 50 mcg of fluticasone propionate. (rxlist.com)
  • Nayzilam is supplied as a spray for intranasal administration. (centerwatch.com)
  • Naloxone HCl Nasal Spray is intended for immediate administration as emergency therapy in settings where opioids may be present. (nih.gov)
  • Naloxone HCl Nasal Spray is for intranasal use only. (nih.gov)
  • Administration of a single spray of Naloxone HCl Nasal Spray intranasally into one nostril. (nih.gov)
  • Regular use of an intranasal steroid spray may be more appropriate for patients with chronic symptoms. (medscape.com)
  • Mean time from drug administration to cessation of seizures was lesser in midazolam (1.6 ± 0.3mins(IN) and 1.6±0.3min(IV) as compared to diazepam (2.26±0.6 min) (p-0.06). (pediatriconcall.com)
  • Seizure control was most prompt with intranasal midazolam . (pediatriconcall.com)
  • 10. Fukuta O, Braham RL, Yanase H, Kurosu K. The sedative effects of intranasal midazolam administration in the dental treatment of patients with mental disabilities. (bvsalud.org)
  • Part 2: optimal concentration of intranasal midazolam. (bvsalud.org)
  • Hemostatic parameters in rats 24 h after single administration of this peptide did not differ from the control level observed in animals receiving 0.85% NaCl. (unboundmedicine.com)
  • Cotton rats infected three days earlier by intranasal instillation of A2 strain of RSV (10.sup.4 pfu/animal) were anesthetized with methoxyflurane and inoculated intraperitoneally (IP) or intranasally (IN) with a varying dose of IVIG. (justia.com)
  • Intranasal administration of IVIG to fully anesthetized cotton rats or monkeys resulted in rapid delivery of the inoculum into the lungs. (justia.com)
  • Cotton rats were sacrificed by carbon dioxide asphyxiation 24 hours after administration of IVIG. (justia.com)
  • Experiment 2: A separate group of rats will receive intranasal CBD administration. (mystateline.com)
  • Validated intranasal administration method in rats should be in place. (scanbalt.org)
  • Consequently, the most convincing animal studies of functional effects of OXT have therefore used intracerebroventricular or intracerebral administration routes. (nature.com)
  • Over the past few decades, the field has seen breathtaking advancements with improved drug formulations, release mechanisms, delivery materials, and administration routes. (wikipedia.org)
  • When utilizing other routes of administration to target the brain, drug adsorption is low due to issues with systemic circulation effects and blood brain barrier. (wikipedia.org)
  • These studies have utilized various routes for drug administration viz . (ijpsonline.com)
  • 2) Thus various alternative routes of administration are under evaluation. (pediatriconcall.com)
  • Various alternative routes of administration are intranasal, rectal, sublingual and buccal. (pediatriconcall.com)
  • Until definitive studies comparing different doses, rates of administration, routes of administration, and other considerations are conducted, firm recommendations are not possible. (psychiatrist.com)
  • Moreover, it has been shown that insulin, melanocyte-stimulating hormone and vasopressin can all cross the BBB and increase cerebrospinal fluid (CSF) as well as blood concentrations within 15-30 min after intranasal administration 8 . (nature.com)
  • Benzodiazepines cross the blood brain barrier promptly achieve peak cerebrospinal (CSF) concentration within minutes of administration. (pediatriconcall.com)
  • After NGF administration, raised levels of both NGF and DCX were found in the cerebrospinal fluid of the patient. (uniroma1.it)
  • Healthy non-pregnant persons aged 2 through 49 years may alternatively receive 0.2 mL of LAIV4, 0.1 mL per nostril, using the supplied intranasal sprayer ( Table 3 ). (cdc.gov)
  • Effective October 14, 2022, pharmacists with valid drug administration certification may administer any Schedule I, IA, and II drugs, including controlled drugs by injection and intranasal route, with the exception of cosmetic drugs and substances, and allergy serums. (bcpharmacists.org)
  • The College must approve your Drug Administration Certification (DAC) application prior to you providing drug administration in accordance with HPA Bylaws Schedule F Part 4 - Certified Practice - Drug Administration by Injection and Intranasal Route Standards, Limits and Conditions . (bcpharmacists.org)
  • CFTA pre-registration applicants and CFTA pre-registration applicants and Temporary registrants who previously completed drug administration training for injection only, must complete the intranasal administration online module and submit the "intranasal administration declaration" through eServices before they may administer a drug by intranasal route. (bcpharmacists.org)
  • Submit the Application for Certification - Drug Administration by Injection and Intranasal Route to the College, along with copies of your drug administration training course certificate(s) and first aid/CPR certificate. (bcpharmacists.org)
  • In order to complete the declaration page of this application, you must read and understand the Certified Practice - Drug Administration by Injection and Intranasal Route Standards, Limits and Conditions . (bcpharmacists.org)
  • If your First Aid/CPR certification expires, your DAC becomes invalid and you must notify the College and cease from administering drugs by injection and intranasal route immediately. (bcpharmacists.org)
  • If you are unable to declare any of the above, you must cease administering drugs by injection and intranasal route immediately. (bcpharmacists.org)
  • Currently, nucleic acid therapies may be delivered via intermittent administration intrathecally or via intracerebroventricular injection or may be introduced by intraparenchymal injection of viral vectors encoding these therapies. (scientificarchives.com)
  • The most common method of vaccine administration is by SC or IM injection. (merckvetmanual.com)
  • Intranasal administration is an attractive route for systemic delivery of small, lipophilic drugs because they are rapidly absorbed through the nasal mucosa into systemic circulation. (healthpartners.com)
  • Intranasal drug delivery occurs when particles are inhaled into the nasal cavity and transported directly into the nervous system. (wikipedia.org)
  • Intranasal particles have to pass through the mucus layer, the first barrier, to then travel from nasal epithelium to brain. (wikipedia.org)
  • At a pH less than 4 it is water soluble but at physiological pH it is highly lipophilic which accounts for its rapid absorption by rich vascular nasal mucosa reaching peak plasma and CSF concentrations within minutes of administration. (pediatriconcall.com)
  • The intranasal route gained interest towards the end of the 20th century with treating cardiovascular and respiratory diseases. (wikipedia.org)
  • More particularly, the present invention is related to a more effective and rapid method of treating lower respiratory tract disease caused by RSV by direct administration of neutralizing antibodies into the lower respiratory tract. (justia.com)
  • There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and behaviour, however as yet no study has actually demonstrated that this modality of administration increases concentrations of the peptide in the brain as well as blood in humans. (nature.com)
  • However, whereas oxytocin plasma concentrations peaked at 15 min after intranasal administration and decreased after 75 min, CSF concentrations took up to 75 min to reach a significant level. (nature.com)
  • Can repeated intranasal oxytocin administration affect reduced neural sensitivity towards expressive faces in autism? (bvsalud.org)
  • FARE (Food Allergy Research & Education) acknowledges the U.S. Food and Drug Administration's (FDA) decision to extend the Prescription Drug User Fee Act (PDUFA) target action date for the New Drug Application (NDA) of neffy® (Intranasal (IN) Epinephrine) by three months to September 19, 2023. (foodallergy.org)
  • Elevated OXT plasma concentrations peaking at 10-40 min after intranasal administration of OXT (30 IU) have been documented in three male volunteers 11 . (nature.com)
  • Objective 2: Demonstrating the pharmacological relevance of brain CBD concentrations following intranasal application (Experiment 3). (mystateline.com)
  • In the acute phase following TBI, there was a marked increase in concentrations of the NLRP3 inflammasome complex and corresponding interleukins, which decreased with the administration of the hMSC-EVs 12 . (tamhsc.edu)
  • Early administration of oral oseltamivir increases the benefits of influenza treatment. (cdc.gov)
  • These can be further subdivided into intranasal and oral therapies. (medscape.com)
  • After a single intranasal dose, the hMSC-EVs were incorporated into microglia throughout injured brain regions, resulting in acute and chronic improvements in TBI mice 12 . (tamhsc.edu)
  • GAITHERSBURG, Md. and BASEL, Switzerland, Nov. 10, 2020 (GLOBE NEWSWIRE) -- Altimmune, Inc. (Nasdaq: ALT), a clinical-stage biopharmaceutical company, today announced that it entered into an agreement with Lonza for the manufacturing of AdCOVID ™ , Altimmune's next-generation, single-dose intranasal vaccine candidate for COVID-19. (yahoo.com)
  • There is likely to be a complex interaction between ketamine dose, session duration, route of administration, frequency of administration, and related practice. (psychiatrist.com)
  • Young adult male C57BL/6 J mice subjected to 30 min of middle cerebral artery occlusion (MCAO) were administered intranasal preparations of E2-GNPs, water soluble E2, or saline as control 1 h after reperfusion. (nih.gov)
  • Animal studies show intranasal administration of pro-resolving lipid mediators decreased both factors, slowing pathogenesis of this disease. (wikipedia.org)
  • This article presents a qualitative review and summary about what is known about ketamine dosing, rate of administration, route of administration, duration of treatment, and frequency of sessions. (psychiatrist.com)
  • 3 The present article examines issues related to dosing, rate of administration, route of administration, duration of treatment, and frequency of sessions when ketamine is used in subanesthetic doses for the treatment of depression, especially treatment-resistant depression. (psychiatrist.com)
  • We have developed a gelatin nanoparticle-mediated intranasal drug delivery system as an efficient, non-invasive method for delivering 17β-estradiol (E2) specifically to the brain, enhancing neuroprotection, and limiting systemic side effects. (nih.gov)
  • Intranasal administration has the advantage of directly affecting the site of action, and, in general, intranasal medications have fewer adverse effects and no systemic effects. (medscape.com)
  • Intranasal delivery of insulin showed greater memory improvement in patients with Alzheimer's than in healthy individuals. (wikipedia.org)
  • Only a few studies reported NGF administration in paediatric patients with severe TBI.Methods: A four-year-old boy in a persistent unresponsive wakefulness syndrome (UWS) was treated with intranasal murine NGF administration 6months after severe TBI. (uniroma1.it)
  • Some patients resist using intranasal medications. (medscape.com)
  • Intranasal drug delivery is one of the important delivery options for brain targeting, as the brain and nose compartments are connected to each other via the olfactory/trigeminal route and via peripheral circulation. (benthamscience.com)
  • The intranasal delivery route is particularly relevant as it may further reduce transmission of the virus and provide a needle-free delivery option. (biospace.com)
  • Thus present study concludes that flexible liposome enriched thermoreversible, mucoadhesive in situ intranasal gel of rizatriptan benzoate is a safe and effective drug delivery system for treatment of migraine. (ijpsonline.com)
  • Training should also be offered to temporary staff who may be filling in on days when the facility is short-staffed or helping during peak periods of vaccine administration such as influenza season. (cdc.gov)
  • Actualización sobre el virus la influenza aviar A (H5N1) en los seres humanos. (cdc.gov)
  • Note: Registrants who have not administered drugs by intranasal route in the preceding three years must complete the intranasal administration online module . (bcpharmacists.org)
  • Increasingly, clinical studies have generated unprecedented interest in the therapeutic targets and potential benefits of intranasal OXT application for neuropsychiatric disorders characterised by social dysfunction, such as social anxiety, autism and schizophrenia 4 . (nature.com)
  • HD is an autosomal dominant neurodegenerative disease for which several clinical trials have demonstrated gene-lowering effects following intrathecal administration. (scientificarchives.com)
  • Further investigation into the therapeutic window, optimal dosage, and clinical trials studying the administration of hMSC-EVs following TBI are necessary before translation into medical practice. (tamhsc.edu)
  • During the late 1980s, William Frey II studied the intranasal route for treating brain diseases. (wikipedia.org)
  • In such case, intranasal route may be a viable alternative as it has advantage of targeting the drug to the brain. (ijpsonline.com)
  • Experiment 3: Building upon the outcomes of Experiment 1, the study will assess intranasal CBD doses that yield significant brain exposure in rat models of anxiety and chronic pain. (mystateline.com)
  • Intranasal nerve growth factor administration improves cerebral functions in a child with severe traumatic brain injury. (uniroma1.it)
  • Avoid administration of LAIV within 2 weeks before or 48 hours after oseltamivir phosphate capsules use, unless medically indicated. (nih.gov)
  • Although a large body of research, ranging from rodents to humans, has reported on the effects of OXT and AVP administration on affiliative and trust behaviors, and has highlighted the genetic contributions of OXT and AVP receptor polymorphisms to both social behaviors and to diseases related to social deficits, the consequences of peptide administration on psychiatric symptoms, and the impact of receptor polymorphisms on receptor function, are still unclear. (frontiersin.org)
  • this administration may be performed in the absence of a seizure episode. (centerwatch.com)
  • Glucagon intranasal is indicated for severe hypoglycemic reactions in adults and children (aged 4 years or older) with diabetes. (medscape.com)
  • This chapter summarizes best practices related to vaccine administration, a key factor in ensuring vaccination is as safe and effective as possible. (cdc.gov)
  • Anticoagulant activity, total and nonenzymatic fibrinolytic activity, and tissue plasminogen activator activity increased, while platelet aggregation and activity of factor XIIIa in rat blood plasma decreased over 3 h after single intranasal administration of proline-containing peptide Pro-Gly-Pro. (unboundmedicine.com)
  • TY - JOUR T1 - Changes in hemostatic parameters after intranasal administration of peptide Pro-Gly-Pro. (unboundmedicine.com)
  • Despite extensive research and very promising results, however, little is known about the pharmacokinetic characteristics of intranasal OXT application. (nature.com)
  • We believe the results from this rabbit toxicology study will support our development strategy for our intranasal COVID-19 vaccine candidate, NT-CoV2-1. (biospace.com)
  • The findings from this preclinical toxicology study will be a part of our Investigational New Drug filing to the U.S. Food and Drug Administration," said Frederick W. Telling, Ph.D., Executive Chairman of Oragenics. (biospace.com)
  • The present study deals with formulation and evaluation of flexible liposome embedded thermoreversible in situ intranasal gel of rizatriptan benzoate. (ijpsonline.com)
  • Policies should be in place to validate health care professional's knowledge of, and skills in, vaccine administration. (cdc.gov)
  • Once initial training has been completed, accountability checks should be in place to ensure staff follow all vaccine administration policies and procedures. (cdc.gov)
  • Professional standards for medication administration, manufacturer instructions, and organizational policies and procedures should always be followed when applicable. (cdc.gov)
  • Specifically, intranasal administration of hMSC-EVs enriched with microglia-modulating miRNAs effectively prevented the common secondary injuries in TBI. (tamhsc.edu)