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  • Infections
  • in humans, more than 50 distinct adenoviral serotypes have been found to cause a wide range of illnesses, from mild respiratory infections in young children (known as the common cold) to life-threatening multi-organ disease in people with a weakened immune system. (wikipedia.org)
  • interaction
  • We also summarize the essential characteristics concerning their interaction with the anti-HAd memory immune responses in humans, the preferential transduction of neurons, and its high level of retrograde axonal transport in the central and peripheral nervous system. (mdpi.com)
  • It is the co-receptor interaction that stimulates entry of the adenovirus. (wikipedia.org)

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  • Infection
  • In this study, we evaluated valganciclovir against disseminated adenovirus type 5 (Ad5) infection in our permissive immunosuppressed Syrian hamster model. (mdpi.com)
  • Epidemiological analysis and follow-up of human rhinovirus infection in children with asthma exacerbation. (semanticscholar.org)
  • Conclusion: The present study provides further evidence of the contribution of adenovirus in causing gastroenteritis in young children, with symptomatic infection being significantly more prevalent in children below one year. (uib.no)
  • However, in monkeys that are immunodeficient-due to, for example, infection with Simian immunodeficiency virus-SV40 acts much like the human JC and BK polyomaviruses, producing kidney disease and sometimes a demyelinating disease similar to PML. (wikipedia.org)
  • AD-36 infection can induce cellular differentiation of 3T3-L1 preadipocytes and stem cells derived from human adipose tissue. (wikipedia.org)
  • Symptoms of respiratory illness caused by adenovirus infection range from the common cold syndrome to pneumonia, croup, and bronchitis. (wikipedia.org)
  • Patients with compromised immune systems are especially susceptible to severe complications of adenovirus infection. (wikipedia.org)
  • Pharyngoconjunctival fever is a specific presentation of adenovirus infection, manifested as: high fever that lasts 4-5 days pharyngitis (sore throat) conjunctivitis (inflamed eyes, usually without pus formation like pink eye) enlargement of the lymph nodes of the neck headache, malaise, and weakness Incubation period of 5-9 days It usually occurs in the age group 5-18. (wikipedia.org)
  • for example, infection with adenovirus 7 acquired by inhalation is associated with severe lower respiratory tract disease, whereas oral transmission of the virus typically causes no or mild disease. (wikipedia.org)
  • Strict attention to good infection-control practices is effective for stopping transmission in hospitals of adenovirus-associated disease, such as epidemic keratoconjunctivitis. (wikipedia.org)
  • Because there is no virus-specific therapy, serious adenovirus illness can be managed only by treating symptoms and complications of the infection. (wikipedia.org)

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  • proteins
  • Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. (gentaur.com)
  • This enzyme catalyses the following chemical reaction Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly-Xaa- and -Yaa-Xaa-Gly-Xaa-Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid) This cysteine endopeptidase is coded by adenoviruses. (wikipedia.org)
  • pathogen
  • Original hosts usually have low death rates when infected with a pathogen, with fatality rates tending to be much higher in new hosts Due to the close relation of humans and nonhuman primates (NHP), disease transmission between NHP and humans is relatively common and can become a major public health concern. (wikipedia.org)
  • occur
  • All the chemical compounds and elements contained in the human body occur in various forms and combinations such as hormones, vitamins, phospholipids and hydroxyapatite. (wikipedia.org)
  • Experimental
  • He played a critical role in developing adenovirus as an experimental system and made many important contributions in virology and molecular biology, leading to over 300 authored/co-authored publications and one U.S. patent (No. 61/509,891). (wikipedia.org)
  • strain
  • A host shifting event is defined as a strain that was previously zoonotic and now circulates exclusively among humans. (wikipedia.org)
  • potentially
  • There is evidence to suggest that some diseases can potentially be re-introduced to human populations through animal hosts after they have been eradicated in humans. (wikipedia.org)
  • biological
  • Good nutrition helps children grow physically, promotes human biological development and helps in the eradication of poverty. (wikipedia.org)
  • Laboratory
  • HEK 293 cells were generated in 1973 by transformation of cultures of normal human embryonic kidney cells with sheared adenovirus 5 DNA in Alex van der Eb's laboratory in Leiden, the Netherlands. (wikipedia.org)
  • saliva
  • Bats, for example, are mammals and can directly transfer rabies to humans through bite and also through aerosolization of bat saliva and urine which are then absorbed by human mucous membranes in the nose, mouth and eyes. (wikipedia.org)
  • Virus
  • SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. (wikipedia.org)
  • Since adenovirus can be excreted for prolonged periods, the presence of virus does not necessarily mean it is associated with disease. (wikipedia.org)
  • mRNA
  • Studies from human hearts have shown that lower expression of CXADR mRNA is associated with a risk allele at chromosome 21q21, which may in fact predispose hearts to arrhythmias. (wikipedia.org)
  • cells
  • Human embryonic kidney cells 293, also often referred to as HEK 293, HEK-293, 293 cells, or less precisely as HEK cells, are a specific cell line originally derived from human embryonic kidney cells grown in tissue culture. (wikipedia.org)
  • Graham and coworkers provided evidence that HEK 293 cells and other human cell lines generated by adenovirus transformation of human embryonic kidney cells have many properties of immature neurons, suggesting that the adenovirus preferentially transformed a neuronal lineage cell in the original kidney culture. (wikipedia.org)
  • Given the location of the adrenal gland (adrenal means "next to the kidney"), a few adrenal cells could plausibly have appeared in an embryonic kidney derived culture, and could be preferentially transformed by adenovirus. (wikipedia.org)
  • cause
  • Adenovirus can cause severe necrotizing pneumonia in which all or part of a lung has increased translucency radiographically, which is called Swyer-James Syndrome. (wikipedia.org)
  • However
  • However, the original adenovirus transformation was inefficient, suggesting that the cell that finally produced the HEK 293 line may have been unusual in some fashion. (wikipedia.org)
  • cell lines
  • A comprehensive study of the genomes and transcriptomes of HEK 293 and five derivative cell lines compared the HEK 293 transcriptome with that of human kidney, adrenal, pituitary and central nervous tissue. (wikipedia.org)
  • group
  • Wildlife zoonotic diseases of microbial origin are also the most common group of human emerging diseases, and CST between wildlife and livestock has appreciable economic impacts in agriculture by reducing livestock productivity and imposing export restrictions. (wikipedia.org)
  • Infections
  • in humans, more than 50 distinct adenoviral serotypes have been found to cause a wide range of illnesses, from mild respiratory infections in young children (known as the common cold) to life-threatening multi-organ disease in people with a weakened immune system. (wikipedia.org)
  • interaction
  • We also summarize the essential characteristics concerning their interaction with the anti-HAd memory immune responses in humans, the preferential transduction of neurons, and its high level of retrograde axonal transport in the central and peripheral nervous system. (mdpi.com)
  • It is the co-receptor interaction that stimulates entry of the adenovirus. (wikipedia.org)
  • recombinant
  • Serum levels of patients experienced pain and granulocyte colony-stimulating factor (G-CSF) has not been shown to 10% of the R1 side chains of the time required for the same manner as recombinant human erythropoietin and are present. (bnnpsulteng.com)
  • species
  • 2-free cholesterol and phospholipids are transferred from triglyceride rich particles to plasma lipoproteins by distinct mechanisms, and 3 - CETP also contributes to phospholipid transfer activity in human plasma but not in transgenic mice plasma, a species which has high levels of the specific phospholipid transfer protein activity. (biomedcentral.com)
  • 2017
  • Vaccines that have been or are made using fetal tissue for the propagation of viruses include: Adenovirus Chicken pox Ebola Polio Rabies Rubella Shingles Of these, the vaccines approved for use in the United States include some of those against rabies (Imovax), rubella, chicken pox, shingles, and adenovirus (as of January 2017). (wikipedia.org)
  • Diagnosis
  • Animal models of vein graft disease are used as preliminary tools to study and understand the pathogenesis of the disease in humans and improve its diagnosis, prevention and therapy. (ebscohost.com)
  • respiratory syncy
  • Bronchiolitis is usually the result of infection by respiratory syncytial virus (72% of cases) or human rhinovirus (26% of cases). (wikipedia.org)
  • This is most commonly caused by respiratory syncytial virus (RSV, also known as human pneumovirus). (wikipedia.org)
  • metabolism
  • Adenoviruses can be a result, lips, base precursor metabolism, including drugs of Medicare beneficiaries still did not have coverage under Medicare where can i buy accutane in nigeria Part D or RNA synthesis. (bnnpsulteng.com)
  • tissue
  • The artificial graft tissue was developed by combining man-made materials with human cells to make it elastic and. (ebscohost.com)
  • activity
  • In cultured adult rabbit pacemaker cells infected with an adenovirus expressing the FRET sensor AKAR3, PKA activity and AP firing rate were tightly linked in response to either adrenergic receptor stimulation (by isoproterenol, ISO) or cholinergic stimulation (by carbachol, CCh). (frontiersin.org)
  • Hypertension
  • Relationship Between Hypertension and Atherosclerosis: From a Viewpoint of the Most Potent Vasoconstrictor Human Urotensin II. (ebscohost.com)
  • Human urotensin II (U-II), the most potent vasoconstrictor peptide identified to date, and its receptor (UT) are involved in etiology of hypertension. (ebscohost.com)
  • cells
  • Smoking and Female Sex: Independent Predictors of Human Vascular Smooth Muscle Cells Stiffening. (ebscohost.com)
  • In vitro, AM inhibited MNC apoptosis, promoted MNC adhesiveness to a human umbilical vein endothelial cell monolayer, and increased the number of MNC-derived endothelial progenitor cells. (ahajournals.org)
  • Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses Y box binding protein 1 has been shown to interact with: ANKRD2, CTCF, P53, PCNA, RBBP6, and SFRS9. (wikipedia.org)
  • Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. (wikipedia.org)
  • disease
  • In humans, this disease is highly fatal if not treated. (mnvet.com)
  • Few experimental trials have evoked a response strong enough to protect against disease and the technique's usefulness remains to be proven in humans. (wikipedia.org)
  • control
  • The effect of the lipases was verified by incubation of labeled ( 3 H-FC, 14 C-PL) triglyceride rich emulsion with human plasma (control, post-heparin and post-heparin plus lipase inhibitor), rat plasma (control and post-heparin) and by the injection of the labeled lipid emulsion into control and heparinized functionally hepatectomized rats. (biomedcentral.com)
  • However
  • However, the mechanism of action supporting the benefits of the combination have been quite different in line with the individual characteristics that every oncolytic adenovirus possesses. (biomedcentral.com)
  • Most research on the TATA box has been conducted on yeast, human, and Drosophila genomes, however, similar elements have been found in archaea and ancient eukaryotes. (wikipedia.org)
  • factor
  • Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A". Biochemical and Biophysical Research Communications. (wikipedia.org)