• Poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors have recently been found to be remarkably toxic to cells with defects in homologous recombination, particularly cells with BRCA-mutated backgrounds. (ac.ir)
  • Rapid synthetic route toward structurally modified derivatives of cyclic adenosine 5'-diphosphate ribose. (ox.ac.uk)
  • A concise synthesis of five new analogues of the second messenger cADPR (cyclic adenosine 5'-diphosphate ribose) is presented. (ox.ac.uk)
  • The synthetic plan centered around the key derivative 8-Br-N1-cIDPR (cyclic 8-Br-inosine 5'-diphosphate ribose, 2), which was prepared in only three steps from IMP (inosine 5'-monophosphate) via an unusual enzymatic cyclization reaction. (ox.ac.uk)
  • Roles for adenosine ribose hydroxyl groups in cyclic adenosine 5'-diphosphate ribose-mediated Ca2+ release. (ox.ac.uk)
  • Cyclic adenosine diphosphate ribose (cADPR) is a naturally occurring and potent Ca2+-mobilizing agent. (ox.ac.uk)
  • These analogues were used to assess the effect of 2'- and 3'-hydroxyl group deletion in the adenosine ribose moiety of cADPR on the Ca2+-releasing potential of cADPR. (ox.ac.uk)
  • These are the first steps toward a wider structure-activity relationship for cADPR, and this is the first study to implicate a crucial role for the adenosine ribose hydroxyl groups of cADPR in the biological activity of this cyclic nucleotide. (ox.ac.uk)
  • Olaparib is a type of drug called a PARP (poly [adenosine diphosphate-ribose] polymerase) inhibitor. (cancersa.org.au)
  • Poly-adenosine diphosphate ribose polymerase or PARP -based targeted therapies are under development and are expected to effectively treat breast cancers. (news-medical.net)
  • The U.S. Food and Drug Administration (FDA) has approved BRCA genetic tests as companion diagnostics to guide cancer treatment with poly adenosine diphosphate-ribose polymerase (PARP) inhibitors . (cdc.gov)
  • In these studies, we investigated whether platelet aggregation accelerates hematogenic metastasis of cancer cells in mice and the effect of cordycepin (3'-deoxyadenosine), a component of Cordyceps sinensis, on hematogenic metastasis accelerated by adenosine-5'-diphosphate (ADP). (nih.gov)
  • The primary endpoint was assessment of platelet aggregation after stimulation with adenosine diphosphate 20 μM at 12-month follow-up. (revespcardiol.org)
  • Reports indicate that oregano oil inhibits arachidonic acid-induced and ADP (adenosine diphosphate)-induced platelet aggregation. (selfgrowth.com)
  • Another segment of the enzyme uses the energy created by this proton flow to convert a molecule called adenosine diphosphate (ADP) to ATP. (medlineplus.gov)
  • Lower intracellular levels of cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) were observed in unstimulated PRP from t-PAPS patients. (acmv.com.co)
  • This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)
  • Michal F, Motamed M. Shape change and aggregation of blood platelets: interaction between the effects of adenosine diphosphate, 5-hydroxytryptamine and adrenaline. (edu.pk)
  • Adenosine diphosphate (ADP), also known as adenosine pyrophosphate (APP), is an important organic compound in metabolism and is essential to the flow of energy in living cells. (wikipedia.org)
  • A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. (bvsalud.org)
  • To further investigate the importance of the 3'-hydroxyl group, we have also synthesized 3'A-O-methyl-cADPR, in which the 3'-hydroxyl group of adenosine has been methylated and its ability potentially to donate a hydrogen atom in a hydrogen bond has been removed. (ox.ac.uk)
  • When an ATP molecule emits a phosphate group and forms ADP (adenosine diphosphate), energy is released. (nobelprize.org)
  • Second, platelets release chemicals, such as adenosine diphosphate (ADP). (msdmanuals.com)
  • As a result, ATP becomes ADP (adenosine diphosphate). (htdig.org)
  • Adenosine diphosphate (ADP) and phosphorus (P) are produced in the process. (hypertextbook.com)
  • A graphical presentation of steps in platelet activation and aggregation and site of action of aspirin (acetylsalicylic acid) and adenosine diphosphate (ADP) antagonists. (medscape.com)
  • Adenosine 5′-diphosphate disodium salt has been used as a purinergic G protein-coupled receptor P2Y12 agonistin platelet activation tests in blood samples. (sigmaaldrich.com)
  • Upon its conversion to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors. (sigmaaldrich.com)
  • This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)
  • Adenylyl cyclase enhances cyclic adenosine monophosphoate (cAMP) which activates protein kinase (PKA) that inhibits platelet shape change, granule secretion, calcium mobilization, and aggregation [ 6 ]. (hindawi.com)
  • Objectives: To strengthen the hemostatic ability of H12-coated particles as a platelet substitute, we exploited installation of a drug delivery function by encapsulating adenosine diphosphate (ADP) into liposomes [H12-(ADP)-liposomes]. (elsevierpure.com)
  • Little is known about how clinicians use platelet function testing to guide choice and dosing of adenosine diphosphate receptor inhibitor (ADPri) therapy in routine community practice. (elsevierpure.com)
  • Methods and Results-The Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (ACS)-Prospective, Open Label, Antiplatelet Therapy Study (TRANSLATE-POPS) was a cluster-randomized trial in which 100 hospitals were assigned access to no-cost platelet function testing versus usual care for acute myocardial infarction patients treated with percutaneous coronary intervention. (elsevierpure.com)
  • Therefore, in the present study, platelet function was measured using a TEG5000 thrombelastograph analyzer and the surgical timing was determined based on the measured maximum amplitude of adenosine diphosphate (MA ADP ) values. (spandidos-publications.com)
  • Thienopyridines were the first family of platelet adenosine diphosphate (ADP)-P2Y12 receptor inhibiting drugs. (escardio.org)
  • The Caerphilly Prospective Study demonstrates a paradoxical association of increased ischaemic stroke risk with decreased whole blood adenosine diphosphate (ADP) induced platelet sensitivity. (cdc.gov)
  • When ATP loses one phosphate group, it becomes Adenosine diphosphate ( ADP ). (wikibooks.org)
  • When ATP loses two phosphate groups it becomes adenosine monophosphate ( AMP ). (wikibooks.org)
  • Energy is released when ATP is broken into ADP+P i (adenosine diphosphate and phosphate group). (nismat.org)
  • Creatine gives up one of its phosphate molecules to adenosine diphosphate (ADP) which in turn creates ATP to be burned as fuel. (ostatic.com)
  • Following Burnstock's pioneering work on the role of ATP-sensitive P2 purinoceptors, its metabolite adenosine soon became recognized as an extracellular signalling molecule through the activation of plasma membrane-bound P1 receptors family that are expressed in every organ systems in the body. (frontiersin.org)
  • The endogenous levels of the purine nucleoside, adenosine, increase significantly following cardiovascular events. (frontiersin.org)
  • The purine nucleoside adenosine was first identified in 1929 when Drury and Szent-Gyorgyi successfully extracted a rhythm-influencing adenylic substance from the mammalian heart and other tissues ( Drury and Szent-Gyorgyi, 1929 ). (frontiersin.org)
  • In this new study, scientists discovered that FABP4 joins with two other proteins-adenosine kinase and nucleoside diphosphate kinase-to form a novel complex they named "Fabkin. (nih.gov)
  • Inhibition by alpha beta methylene adenosine 5'-diphosphate. (nih.gov)
  • Inhibition of the adenosine diphosphate (ADP) P2Y12 receptor plays a key role in antithrombotic therapy as shown by many clinical trials demonstrating the clinical benefit associated with adjunctive clopidogrel therapy in high-risk settings. (escardio.org)
  • The diphosphate group of ADP is attached to the 5' carbon of the sugar backbone, while the adenine attaches to the 1' carbon. (wikipedia.org)
  • Here, we provide a comprehensive and up-to-date critical review about the main therapeutic advantages of tuning adenosine signalling pathways in HFpEF, without discounting their side effects and how these can be seized. (frontiersin.org)
  • Comparison between Balance-coated and uncoated in vitro bench test circuits of percentage of platelets that are activated with adenosine diphosphate (ADP @ 20 µM) in circulating heparinised human blood over time. (medtronic.com)
  • When BiP folds a protein, the ATP is converted to a similar molecule called adenosine diphosphate (ADP). (medlineplus.gov)
  • 18. Characterization of total adenosine deaminase activity (ADA) and its isoenzymes in saliva and serum in health and inflammatory conditions in four different species: an analytical and clinical validation pilot study. (nih.gov)
  • During muscle contractions, ATP is hydrolysed to Adenosine Diphosphate (ADP). (betterbodz.com)
  • 11. Correlation of serum levels of adenosine deaminase activity and its isoenzymes with disease activity in rheumatoid arthritis. (nih.gov)
  • ATP is broken down into adenosine diphosphate (ADP) and ADP, and re-formed in the cell. (resepbunda.co)
  • Human Adenosine diphosphate ELISA kit is suitable for the detection of samples from human species. (elisakit.cc)
  • Our goal was to compare the safety and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, with clopidogrel in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS). (nih.gov)
  • 3. Adenosine deaminase activity in COPD patients and healthy subjects. (nih.gov)
  • 4. Simvastatin up-regulates adenosine deaminase and suppresses osteopontin expression in COPD patients through an IL-13-dependent mechanism. (nih.gov)
  • 6. Serum adenosine deaminase, 5'-nucleotidase & alkaline phosphatase in breast cancer patients. (nih.gov)
  • Ces résultats semblent indiquer que l'utilisation de l'alun en tant qu'antiplaquettaire oral pourrait faire l'objet d'études complémentaires, en tenant compte des effets secondaires éventuels notamment chez les patients dont la fonction rénale est altérée. (who.int)