• Types include: clear-cell adenocarcinoma of the vagina ovarian clear-cell carcinoma uterine clear-cell carcinoma clear-cell adenocarcinoma of the lung (which is a type of clear-cell carcinoma of the lung). (wikipedia.org)
  • Cancers from distant sites that metastasize to the vagina through the blood or lymphatic system also occur, including colon cancer, renal cell carcinoma, melanoma, and breast cancer. (medscape.com)
  • An Isolated Metastasis From Clear Cell Renal Cell Carcinoma to the Uterus: A Case Report and Review of Literature. (beds.ac.uk)
  • There are five subtypes of ovarian carcinoma that are sufficiently distinct and well-characterized that they should be considered to be different diseases, i.e. high-grade serous, clear cell, endometrioid, mucinous and low-grade serous, from most to least common, respectively. (nih.gov)
  • 28. Concordant clear cell "mesonephric" carcinoma of the bladder and lung adenocarcinoma with clear cell features - multiple primaries versus metastatic neoplasms: a case report. (nih.gov)
  • 33. Immunohistochemical Panel for Differentiating Renal Cell Carcinoma with Clear and Papillary Features. (nih.gov)
  • 35. Immunohistochemical analysis of clear cell carcinoma of the gynecologic tract. (nih.gov)
  • 39. Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma. (nih.gov)
  • 40. Napsin A and WT 1 are useful immunohistochemical markers for differentiating clear cell carcinoma ovary from high-grade serous carcinoma. (nih.gov)
  • Carcinoma is a type of cancer that starts in cells that make up the skin or the tissue that lines organs and glands. (nih.gov)
  • The incidence of renal cell carcinoma (RCC) is increasing worldwide, and its prevalence is particularly high in some parts of Central Europe. (nature.com)
  • Ovarian clear cell carcinoma (OCCC) is one of the rare subtypes of ovarian cancer, yet its prognosis is extremely poor. (centerwatch.com)
  • Squamous cell carcinoma (SCC) of the vagina is linked to HPV infection and has many of the same risk factors as SCC of the cervix. (vicc.org)
  • Most female patients with urethral carcinoma are diagnosed with urothelial carcinoma, squamous cell carcinoma, or adenocarcinoma. (biomedcentral.com)
  • The remainder include primary and secondary adenocarcinomas, secondary squamous cell carcinoma (in older women), clear cell adenocarcinomas (in young women), and melanoma. (health.am)
  • Having a human papilloma virus (HPV) infection, which can be linked to squamous cell carcinoma of the vagina. (mottchildren.org)
  • Because it develops in the tissue lining of the ovaries or fallopian tubes, epithelial ovarian cancer is also classified as a carcinoma, as opposed to cancer that develops in the blood, lymphatic cells, or other parts of the body. (moffitt.org)
  • Low-grade serous carcinoma, the fourth most common type of ovarian cancer, typically has slower-growing cancer cells than high-grade serous ovarian cancer. (moffitt.org)
  • Squamous cell carcinoma most often occurs between the ages of 50 and 70 years old. (cancer.net)
  • The average age of people diagnosed with squamous cell carcinoma is 67 years old, and about 80% are older than 50. (cancer.net)
  • A total of 36 cases of lung squamous cell carcinoma (LUSC) and 31 cases of lung adenocarcinoma (LUAD) were included. (spandidos-publications.com)
  • NSCLC is primarily divided into lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). (spandidos-publications.com)
  • termFormat EnglishLanguage MPATH--306 "signet ring cell carcinoma") (subclass MPATH--361 MPATH--358) (subclass MPATH--42 MPATH--33) (subclass MPATH--196 MPATH--194) (subclass MPATH--163 MPATH--162) (termFormat EnglishLanguage MPATH--226 "eccrine gland adenoma") (termFormat EnglishLanguage MPATH--33 "intracellular and extracellular accumulation") (documentation Smo-Subset EnglishLanguage "Subset of OBO terms from the ontology. (ontologyportal.org)
  • Clear cell adenocarcinoma of the vagina and cervix were previously shown to be tumors occurring in female offspring exposed prenatally to diethylstilbestrol. (medscape.com)
  • Cervical cancer happens when cells in the cervix, the lower part of the uterus that connects to the vagina, start to become abnormal. (mayoclinic.org)
  • Vaginal cancer is a disease in which malignant (cancer) cells form in the vagina. (vicc.org)
  • Cancer that forms in the thin, flat cells lining the inside of the vagina. (vicc.org)
  • Squamous cell vaginal cancer spreads slowly and usually stays near the vagina, but may spread to the lungs , liver , or bone. (vicc.org)
  • Glandular cells in the lining of the vagina make and release fluids such as mucus . (vicc.org)
  • A procedure to collect cells from the surface of the cervix and vagina. (vicc.org)
  • A piece of cotton, a brush, or a small wooden stick is used to gently scrape cells from the cervix and vagina. (vicc.org)
  • Then, a brush is inserted into the vagina to collect cells from the cervix. (vicc.org)
  • Women whose mothers took DES while pregnant have an increased risk of cervical cell abnormalities and of clear cell adenocarcinoma of the vagina and cervix. (oncolink.org)
  • People whose mothers took this drug during their pregnancy between the late 1940s and 1971 have an increased risk of clear cell adenocarcinoma of the vagina. (cancer.net)
  • Specific tumour suppressor genes with promoter methylation in ovarian clear cell adenocarcinoma (OCCA) can be one important epigenetic mark distinguishing OCCA from ovarian serous adenocarcinoma (OSA), benign endometriotic cysts and normal ovarian epitheliums. (nih.gov)
  • To assess changes in the number of circulating endothelial cells (CECs) following three days of treatment with olaparib, combination olaparib/cediranib, or standard platinum-based chemotherapy in women with recurrent platinum-sensitive ovarian, primary peritoneal, or fallopian tube cancer. (ucbraid.org)
  • Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer. (nih.gov)
  • In either case, ovarian cancer most commonly develops in the epithelial cells, which are in the outer surface tissue of the ovaries or fallopian tubes. (moffitt.org)
  • Epithelial ovarian carcinomas can be broken down into many subtypes based on their cells' features. (moffitt.org)
  • Also called "clear cell adenocarcinoma," this is a rare type of epithelial ovarian cancer in which the cells look clear when viewed under a microscope. (moffitt.org)
  • One of the rarest forms of ovarian cancer, this subtype is characterized by tumors with abnormal mucus-secreting cells. (moffitt.org)
  • A rare malignant, epithelial ovarian neoplasm, composed of clear, eosinophilic and hobnail cells displaying variable degrees of tubulocystic, papillary and solid histological patterns, macroscopically appearing as a typically unilateral mass in the ovary which ranges from solid to cystic. (cdc.gov)
  • All endometrial cancers are adenocarcinomas. (cancer.org)
  • Approximately 85% of renal cell cancers are adenocarcinomas, mostly of proximal tubular origin. (cancer.gov)
  • 25. Immunohistochemical profile of the penile urethra and differential expression of GATA3 in urothelial versus squamous cell carcinomas of the penile urethra. (nih.gov)
  • Approximately 90% of renal cancers are renal cell carcinomas (RCCs) that develop in the renal parenchyma 2 , with conventional (clear cell) RCC (ccRCC) being the most common (70-80%) histological type. (nature.com)
  • Most of the remainder are transitional cell carcinomas of the renal pelvis. (cancer.gov)
  • The purpose of this study is to understand the metabolism of cancers involving the kidney, including renal cell carcinomas and urothelial cell carcinomas, and how kidney cancers use different types of fuel to support tumor growth. (centerwatch.com)
  • Most (95%) vaginal malignancies are squamous cell carcinomas. (health.am)
  • Type II tumors are usually high-grade and include grade 3 endometrioid carcinomas and tumors with nonendometrioid histology (eg, serous, clear cell, mixed cell, undifferentiated, carcinosarcoma). (msdmanuals.com)
  • Secretory adenocarcinomas of the endometrium are uncommon tumors distinct from clear cell carcinomas. (keyopinionleaders.com)
  • Whether pancreatic cancer cells produce neoantigens-proteins that can be effectively targeted by the immune system-hasn't been clear. (nih.gov)
  • It is designed to help immune cells recognize specific neoantigens on patients' pancreatic cancer cells. (nih.gov)
  • In half these patients, the vaccines activated powerful immune cells, called T cells, that could recognize the pancreatic cancer specific to the patient. (nih.gov)
  • These results suggest that the T cells activated by the vaccines kept the pancreatic cancers in check. (nih.gov)
  • Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer. (nih.gov)
  • Pancreatic adenocarcinoma (PAAD/PCa) is estimated to be the second cause of cancer-related deaths worldwide in the next 10 years [ 1 , 2 ]. (hindawi.com)
  • 21. Nephrogenic adenoma: immunohistochemical evaluation for its etiology and differentiation from prostatic adenocarcinoma. (nih.gov)
  • This case first appeared as Performance Improvement Program in Surgical Pathology (PIP) 2020, Case 29, and is metastatic prostatic adenocarcinoma found in a pre-sacral mass. (cap.org)
  • This is most consistent with a diagnosis of metastatic prostatic adenocarcinoma . (cap.org)
  • Prostatic adenocarcinoma is the second most common cause of cancer-related death in men. (cap.org)
  • The most common histologic type of prostatic adenocarcinoma is acinar adenocarcinoma. (cap.org)
  • Acinar prostatic adenocarcinoma cells are cuboidal, with amphophilic to clear cytoplasm and prominent nucleoli. (cap.org)
  • These findings are highly suggestive of prostatic adenocarcinoma, but not diagnostic. (cap.org)
  • Prostatic adenocarcinoma is graded using the Gleason system, which was developed by Dr. Donald Gleason in 1966. (cap.org)
  • The Gleason system uses histoarchitectural patterns to separate prostatic adenocarcinoma into five grades. (cap.org)
  • Gleason grades 1 and 2 are no longer used in practice to grade prostatic adenocarcinoma. (cap.org)
  • In general, it is not recommended to grade metastatic prostatic adenocarcinoma. (cap.org)
  • Histologically, the tumor consisted of atypical cells with eosinophilic cytoplasm and enlarged nuclei, forming cribriform, solid, or trabecular structures, which was similar to prostatic cancer. (biomedcentral.com)
  • Illustrating this fact, the well-described ductal subtype of prostatic adenocarcinoma is frequently associated with conventional-type acinar adenocarcinoma, and has a tendency to propagate within adjacent intact prostatic ducts. (bmj.com)
  • Each of the three anatomically distinct zones of the prostate has its own set of periurethral main prostatic ducts lined by several layers of urothelial-like cells, reminiscent of the urothelium. (bmj.com)
  • The tall columnar cells lining the larger ducts resemble the cells lining the smaller ducts and acini in their staining patterns with prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP). (bmj.com)
  • 2 Thus, following this approach, prostatic ductal lesions are derived from the large periurethral ducts, and the lesional cells tend to share their tall columnar morphology. (bmj.com)
  • Most prostatic adenocarcinomas are hormone dependent and majority respond to some form of androgen deprivation. (webpathology.com)
  • The incidence of adenocarcinoma of the cervix is increasing within the US, but this diagnostic category is not typically associated with teenaged patients. (umn.edu)
  • And during these screenings, a provider collects cells from the cervix to be tested in the lab. (mayoclinic.org)
  • Cervical cancer is a disease in which cancer cells develop in the tissues of the cervix. (healthywomen.org)
  • Background: Clear cell adenocarcinoma of the urethra (CCAU) is extremely rare and a number of clinicians may be unfamiliar with its diagnosis and biological behaviour. (netkumar1.co.in)
  • There has been scarce information about clear cell adenocarcinoma of the urethra (CCAU), an extremely rare type of cancer. (jocmr.org)
  • Clear cell adenocarcinoma of the urethra (CCAU), an extremely rare type of cancer, has been reported to occur more commonly in the female than in male [ 1 ]. (jocmr.org)
  • 22. Clear cell adenocarcinoma of the male urethra. (nih.gov)
  • 26. Clear cell adenocarcinoma of the male urethra in association with so-called nephrogenic metaplasia. (nih.gov)
  • 30. Clear cell adenocarcinoma of the urethra with inguinal lymph node metastases: A rare case report and review of literature. (nih.gov)
  • 32. Clear cell adenocarcinoma of the female urethra: magnetic resonance imaging. (nih.gov)
  • In 1971, an epidemiologic study reported that the risk of development of a rare form of malignant vaginal and cervical cancer, clear cell adenocarcinoma (CCA), was related to intrauterine exposure to DES. (nih.gov)
  • Endometrial cancer (also referred to as corpus uterine cancer or corpus cancer) is the most common female genital cancer in the developed world, with adenocarcinoma of the endometrium the most common type. (medscape.com)
  • Multiple epidemiological risk factors have been identified in patients who have adenocarcinoma of the endometrium. (medscape.com)
  • Small changes in the cell DNA tells them to multiply out-of-control, and cells accumulate in growths called tumors. (mayoclinic.org)
  • Clear cell tumors of the lung are rare benign pulmonary neoplasms that contain an abundant amount of glycogen. (radiopaedia.org)
  • It is often classified under the spectrum of p erivascular epithelioid cell tumors (PEComas) . (radiopaedia.org)
  • 2. Liebow AA, Castleman B. Benign clear cell ("sugar") tumors of the lung. (radiopaedia.org)
  • Renal cell cancer is one of the few tumors in which well-documented cases of spontaneous tumor regression in the absence of therapy exist, but this regression occurs rarely and may not lead to long-term survival. (cancer.gov)
  • however, the two cell types may occur together in some tumors. (cancer.gov)
  • Some investigators have found that granular cell tumors have a worse prognosis, but this finding is not universal. (cancer.gov)
  • Gene mutations and infiltration immune cells in PCa tumors were analyzed using online databases. (hindawi.com)
  • Malignant glandular cells were detected on both conventional and Thin Prep™ gynecologic tests with histologic confirmation. (umn.edu)
  • Mesothelioma is a rare form of cancer in which malignant (cancerous) cells are found in the mesothelium, a protective sac that covers most of the body's internal organs. (ehso.com)
  • Late recurrence of a uterine clear cell adenocarcinoma confined to an endometrial polyp: case report. (beds.ac.uk)
  • My sister is 51 yrs old and just diagnosed with Stage IV Uterine Adenocarcinoma that has spread to both pelvic, vertebra & the shoulder. (cancer.org)
  • A high-grade endometrial adenocarcinoma characterized by the presence of large neoplastic cells that display at least focal cytoplasmic clearing. (beds.ac.uk)
  • The tumor cells (center of the image) show prominent cytoplasmic clearing secondary to androgen deprivation therapy received by the patient. (webpathology.com)
  • While it isn't perfectly clear what sparks the cervical cells to change their DNA, it is certain that human papilloma virus, or HPV, plays a role. (mayoclinic.org)
  • For more advanced cervical cancer, there's also chemotherapy, a drug that runs the body killing cancer cells in its path. (mayoclinic.org)
  • When a high-risk HPV infection lasts for years, it can lead to changes in the cervical cells, resulting in a precancerous lesion. (oncolink.org)
  • Being exposed to a drug called diethylstilbestrol (DES) in the womb is an independent risk factor for a type of cervical cancer called clear cell adenocarcinoma . (oncolink.org)
  • Dethylstilboestrol (a synthetic oestrogen, now withdrawn) used by women during pregnancy is a cause of vaginal and cervical clear-cell adenocarcinoma in their daughters. (wcrf.org)
  • Different cells called columnar (or glandular) cells line the cervical canal. (healthywomen.org)
  • Acinar adenocarcinoma occurs predominantly in the posterolateral aspects (peripheral zone) of the prostate. (cap.org)
  • 29. Female urethral adenocarcinoma: evidence for more than one tissue of origin? (nih.gov)
  • Biopsy specimens showed urethral adenocarcinoma that was positive for prostate-specific antigen. (biomedcentral.com)
  • We report a significantly rare case of a female patient with urethral adenocarcinoma arising from the Skene duct who presented with serum prostate-specific antigen (PSA) elevation. (biomedcentral.com)
  • The specimens revealed urethral adenocarcinoma with immunohistochemically positive staining for PSA. (biomedcentral.com)
  • The histological diagnosis was Skene adenocarcinoma based on the results of immunohistochemical staining showing positivity for PSA, P504S, and cancer antigen 125. (biomedcentral.com)
  • Cancer that begins in glandular cells. (vicc.org)
  • A report on a case of a 19-year-old woman, with no history of diethylbestrol exposure in uteri, diagnosed with clear-cell endocervical adenocarcinoma is made. (umn.edu)
  • International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix. (beds.ac.uk)
  • This could include a punch biopsy that collects tiny samples of cells, or an endocervical curettage that uses a narrow instrument to take an internal tissue sample. (mayoclinic.org)
  • This RFA, Follow-Up of Patients with DES-Associated Clear Cell Adenocarcinoma, is related to the priority area of cancer. (nih.gov)
  • MMMT is a cancer of the muscle cells of the uterus. (cancer.org)
  • If you've been told that you have adenocarcinoma, it means that you have cancer in the glands that line your organs. (cancer.org)
  • Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. (uci.edu)
  • HPV DNA tests examine the cell specifically for HPV that can lead to pre-cancer. (mayoclinic.org)
  • Radiation therapy uses high-powered beams with energy focused on the cancer cells. (mayoclinic.org)
  • There's also targeted drug therapy that blocks specific weaknesses present within the cancer cells. (mayoclinic.org)
  • And immune therapy, a drug treatment that helps your immune system recognize cancer cells and attack them. (mayoclinic.org)
  • Renal cell cancer, also called renal adenocarcinoma or hypernephroma, can often be cured if it is diagnosed and treated when still localized to the kidney and the immediately surrounding tissue. (cancer.gov)
  • Because most patients are diagnosed when the tumor is still relatively localized and amenable to surgical removal, approximately 75% of all patients with renal cell cancer survive for 5 years. (cancer.gov)
  • For more information, see Transitional Cell Cancer of the Renal Pelvis and Ureter Treatment . (cancer.gov)
  • The staging system for renal cell cancer is based on the degree of tumor spread beyond the kidney. (cancer.gov)
  • The American Joint Committee on Cancer (AJCC) has designated staging by TNM (tumor, node, metastasis) classification to define renal cell cancer. (cancer.gov)
  • Adenocarcinoma is more likely than squamous cell cancer to spread to the lungs and lymph nodes . (vicc.org)
  • Mesothelioma (cancer of the mesothelium) is a disease in which cells of the mesothelium become abnormal and divide without control or order. (ehso.com)
  • Cancer cells can also metastasize (spread) from their original site to other parts of the body. (ehso.com)
  • This drug, called an immune checkpoint inhibitor, prevents cancer cells from suppressing the immune system. (nih.gov)
  • By a year and a half after treatment, the cancer had not returned in any of the people who had a strong T cell response to the vaccine. (nih.gov)
  • Its name includes "serous" because, in this type of cancer, the malignancy develops in the serous membrane of the epithelial layer of cells lining the patient's abdominopelvic cavity. (moffitt.org)
  • This type of therapy uses drugs to stimulate a patient's immune system to better recognize and destroy cancer cells. (moffitt.org)
  • however, its efficacy in different subtypes of non‑small cell lung cancer (NSCLC) is unknown. (spandidos-publications.com)
  • Notably, 85% of patients with lung cancer are diagnosed with non-small cell lung cancer (NSCLC) ( 2 ). (spandidos-publications.com)
  • The Pap test looks for abnormal cell changes that may be mild, moderate or severe precancer or cancer. (healthywomen.org)
  • Screening is meant to find precancer cells and treat them before they progress to invasive cancer. (healthywomen.org)
  • Strikingly, our analysis highlight similarities between stem cell and cancer proteostasis, and diametrically opposed chaperome deregulation between cancers and neurodegenerative diseases. (biorxiv.org)
  • Here we undertake whole-genome and transcriptome sequencing of clear cell RCC (ccRCC), the most common form of the disease, in patients from four different European countries with contrasting disease incidence to explore the underlying genomic architecture of RCC. (nature.com)
  • After my surgery my pathology report looked good with just a 3mm Myometrial invasion, and clear lymph nodes, fallopian tubes, and ovaries. (cancer.org)
  • This model modulated PCa tumor progression and prognosis by regulating immune cell infiltration. (hindawi.com)
  • The cells are checked under a microscope for signs of disease. (vicc.org)
  • Besides, there is increasing evidence showing that immune cell infiltration plays a vital role in the disease progression by regulating tumor microenvironment or immunosuppression [ 18 , 19 ]. (hindawi.com)
  • The glandular epithelium is composed of pseudostratified cuboidal or low columnar cells with moderate, basophilic cytoplasm and ovoid nuclei, sometimes showing small nucleoli. (lww.com)
  • Accordingly, they are abundantly expressed in cytoplasm of skeletal and cardiac muscle cells. (molcells.org)
  • The CheckMate 816 trial was a rare exception to this practice, but it is clear that evidence for the efficacy of neoadjuvant immunotherapy in lymph nodes is insufficient ( 12 ). (spandidos-publications.com)
  • Clear-cell adenocarcinoma is a type of adenocarcinoma that shows clear cells. (wikipedia.org)
  • The line where the two cell types meet-called the squamocolumnar junction (SCJ) is part of the T-zone, and the normal change process of one cell type to another creates metaplastic cells. (healthywomen.org)
  • In this study, we describe a novel function of TNNC1 (Troponin C1, Slow Skeletal and Cardiac Type), a component of actin-bound troponin, as a tumor suppressor of lung adenocarcinoma (LUAD). (molcells.org)
  • Among the eight patients with strong immune responses, half had T cells target more than one vaccine neoantigen. (nih.gov)
  • A rare cause of hemoptysis: benign sugar (clear) cell tumor of the lung. (radiopaedia.org)
  • Benign clear (sugar) cell tumor of the lung with CD1a expression. (radiopaedia.org)
  • 6. Jordá aragón C, Froufe sánchez A, Padilla alarcón J. [Benign clear cell tumor of the lung]. (radiopaedia.org)
  • The recovery of physiological functionality, which is commonly seen in tissue mimetic three-dimensional (3D) cellular aggregates (organoids, spheroids, acini, etc.), has been observed in cells of many origins (primary tissues, embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and immortal cell lines). (mdpi.com)
  • Gleason grade 5 includes solid growth, single infiltrative cells, cords of cells, or cases with comedonecrosis. (cap.org)