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  • purine
  • In theory, this deficiency may alter exercise energy metabolism by impairing the purine nucleotide cycle (PNC) and reducing tricarboxylic acid (TCA) cycle anaplerosis. (wiley.com)
  • The muscle biopsies were analysed for AMPD activity, purine nucleotides/nucleosides and bases, creatine, phosphocreatine, amino acids, and the TCA cycle intermediates malate, citrate and fumarate. (wiley.com)
  • rate of adenine
  • Butacaine does not alter either the total number of atractyloside-sensitive binding sites of depleted mitochondria, or the affinity of these sites for ADP or ATP under conditions where a partial inhibition of the rate of adenine nucleotide translocation is observed. (biochemj.org)
  • The first few nucleotides added by PAP are added very slowly, but the short polyadenine tail is then bound by PABPII, which accelerates the rate of adenine addition by PAP. (wikipedia.org)
  • Extracellular
  • Herbert Zimmermann (born 10 January 1944) is a German neuroscientist who pioneered the studies on the biochemical, structural and functional heterogeneity of cholinergic synaptic vesicles from the electric organ of the electric ray Torpedo, and the functional and biochemical characterization of enzymes hydrolyzing extracellular nucleotides. (wikipedia.org)
  • Starting from the observation that ATP is hydrolyzed extracellularly he analyzed the biochemical pathways leading to the extracellular breakdown of released nucleotides to their respective nucleosides. (wikipedia.org)
  • metabolic
  • These data suggest that the DNA content of groundwater bacteria may be more sensitive than their A(T) to the degree of carbon loading, which may have significant ramifications in the use of nucleic acids and adenine nucleotides for estimating the metabolic status of bacterial communities within more highly contaminated aquifers. (usgs.gov)
  • 7. We conclude that ADP and adrenaline, like thrombin and collagen, cause extrusion of non-metabolic granula-located platelet adenine nucleotides. (biochemj.org)
  • Role
  • Changes in the tissue compartmentation of adenine nucleotides probably play a major role in producing the previously observed increase of cyclic adenosine 3',5'-phosphate during electrical stimulation of slices. (aspetjournals.org)
  • More recently he analyzed the proteome of synaptic vesicles and the role of nucleotide signaling in the control of adult neurogenesis, the formation of new neurons in the adult mammalian brain. (wikipedia.org)
  • found
  • The specific activities of the adenine nucleotides were found to be significantly higher during a pulse label period performed at the end of the last thermal period than at any time during the subsequent synchronous division cycle. (springer.com)
  • cells
  • In cells induced to divide synchronously through heat treatment (cyclic pulses of 34 °C for 30 min alternating with a 30 min recovery period at 28 °C) variations occurred in the levels of adenine nucleotides when samples of cells were analysed at the end of the last thermal period and at various times preceding the first synchronous cell division. (springer.com)
  • formation
  • 5. When secondary aggregation took place while radioactive adenine was being taken up by the platelets, increased formation of labelled hypoxanthine still occurred, but there was either no change or an increase in the concentration of labelled ATP. (biochemj.org)
  • release
  • Addition of [ 3 H]adenine at different stages of biphasic aggregation showed that more [ 3 H]hypoxanthine was formed during than after the release step. (biochemj.org)
  • different
  • Amounts of ATP and ADP as well as the radioactivity of ATP, ADP, AMP, IMP, hypoxanthine and adenine were determined in platelets and plasma at different stages of aggregation. (biochemj.org)
  • This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. (wikipedia.org)
  • Groups
  • This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). (wikipedia.org)