Wilkinson, B 2013, ' 1-(Acyloxy)benzotriazoles: useful reagents for the regioselective acylation of diols ', Australian Journal of Chemistry , vol. 66, no. 8, pp. 910 - 912. (monash.edu)
The scope of the reaction was explored by employment of different aromatic hydrocarbons in conjunction with anhydrides and acylation reagents. (irb.hr)
Different derivatization reagents in a kit for development of a suitable derivatization method (acylation). (mn-net.com)
Protein14
Protein acylation is the post-translational modification of proteins via the attachment of functional groups through acyl linkages. (wikipedia.org)
Protein acylation has been observed as a mechanism controlling biological signaling. (wikipedia.org)
In this study, researchers have used two assays to monitor protein acylation. (news-medical.net)
Further, this research has also shown that following synthesis, acylation of the S protein takes place in the ER by ZDHHC20. (news-medical.net)
Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: a study in rat pancreatic islets. (diabetesjournals.org)
Because protein acylation might be a sequel of cytosolic long-chain acyl-CoA accumulation, we examined if this reaction is engaged in nutrient stimulation of insulin release, using cerulenin, an inhibitor of protein acylation. (diabetesjournals.org)
The finding is consistent with a prominent role of protein acylation in the process of beta-cell nutrient sensing. (diabetesjournals.org)
Acylation-stimulating protein (ASP) acts as a paracrine signal to increase triglyceride synthesis in adipocytes. (escholarship.org)
This study aimed to develop a method for protein fatty acylation research. (growkudos.com)
It's intended for detection of gross changes in protein acylation profile through gas liquid chromatography-based analysis. (growkudos.com)
This study investigated variations in the potent lipogenic factor acylation-stimulating protein (ASP), and examined its association with hormonal and lipid profile alterations across the menstrual cycle. (elsevierpure.com)
S-acylation is a common post-translational modification of membrane protein cysteine residues with many regulatory roles. (st-andrews.ac.uk)
S-acylation adjacent to transmembrane domains has been described in the literature as affecting diverse protein properties including turnover, trafficking and microdomain partitioning. (st-andrews.ac.uk)
Friedel-Crafts Ac8
For example, Friedel-Crafts acylation uses acetyl chloride (CH3COCl) as the agent and aluminum chloride (AlCl3) as a catalyst to add an acetyl group to benzene: This reaction is an example of electrophilic aromatic substitution. (wikipedia.org)
An iron(III) chloride hexahydrate-catalyzed Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs) has been developed. (beilstein-journals.org)
The Friedel-Crafts acylation is one of the oldest metal-catalyzed reactions in organic chemistry [1] and allows for the synthesis of a broad range of diverse compounds [2-5] . (beilstein-journals.org)
In this contribution, we present the use of imidazolium-based tunable aryl alkyl ionic liquids (TAAILs) in a catalytic Friedel-Crafts acylation. (beilstein-journals.org)
The most common acylation reaction is a Friedel-Crafts acylation, named after the scientist who discovered it. (whatismeaningof.com)
The Friedel crafts alkylation generally gives polyalkylated products, so the Friedel crafts acylation is a valuable alternative. (whatismeaningof.com)
You can also state the example as, Friedel-Crafts acylation utilizes acetyl chloride (ethanoyl chloride), CH3COCL, as the medium and aluminum chloride (AlCl3) as an activator to substitute an ethanoyl (acetyl) group to benzene. (whatismeaningof.com)
The catalytic behaviour of hierarchical BEA zeolites with Si/Al ratio of 12.5 and 32 was studied in Friedel-Crafts acylation reactions using furan, anisole and pyrrole as substrates and acetic anhydride as acylating agent. (ua.pt)
Amines3
The substrate to be acylated and the product include the following: alcohols, esters amines, amides arenes, ketones A particularly common type of acylation is acetylation, the addition of the acetyl group. (wikipedia.org)
TFAA is an Acylation Reagent for GC Derivatization that is most commonly used for ECD and reacts with alcholos, amines, and phenols. (aurora-borealis.nl)
The significance of the acylation reaction of amines is presented in the literary reference information. (edu.ua)
Acylation of benzene refers to the substitution of an acyl group (RCO-) onto a benzene ring. (chemistrystudent.com)
Reagent1
Which is the proper reagent for acylation? (gwb.ee)
Reaction7
To do this an acylation reaction is performed, then the carbonyl is removed by Clemmensen reduction or a similar process. (wikipedia.org)
Importantly, this reac- tion may indicate a prebiotically plausible reaction pathway for the se- lective acylation of key metabolites to facilitate their incorporation into protometabolism. (ucl.ac.uk)
In the procedure of acylation , the electrophilic aromatic substitution permits the coalescence of monoacylated products from the reaction between arenes and acyl chlorides or anhydrides. (whatismeaningof.com)
In simpler words, you can also define the term acylation as it is an organic chemical reaction used to add an acyl group to a compound. (whatismeaningof.com)
The process of acylation can be explained more easily with the help of reaction. (whatismeaningof.com)
To determine the optimal conditions for the acylation reaction of AP with the help of AcOH in a pilot plant, the effects of temperature, molar ratio of initial compounds, reaction time on the yield and selectivity of the target product were studied. (neftemir.ru)
The study of the acylation reaction was carried out in the temperature range of 120-1600C, the reaction time was 20-50 minutes, the molar ratio of AP:AcOH was within 1:0.5÷3. (neftemir.ru)
Catalyst2
I've determined that ZnCl2 is a 'good' catalyst for some FC acylations ( a whole day surfing. (sciencemadness.org)
Thus, we were in need of an alternative and practical method for the preparation of com- pound A . The use of TFAA (trifluoroacetic anhydride)/H 3 PO 4 as an e ffi cient catalyst system for C-acylation of various aromatic compounds is reported in the literature. (dokumen.tips)
TFAA1
A similar C - N bond formation under acidic conditions is not common in the literature and to the best of our knowledge the use of TFAA/H 3 PO 4 for the N-acylation purpose has not been explored earlier. (dokumen.tips)
Aromatic compounds2
Starting from electron-rich aromatic compounds, acylation is possible by an organic acid chloride/acid anhydride and a Lewis acid [6,7] . (beilstein-journals.org)
A new method for the directed meta acylation of aromatic compounds is described. (mit.edu)
Fatty5
One prominent type is fatty acylation, the addition of fatty acids to particular amino acids (e.g. myristoylation, palmitoylation or palmitoleoylation). (wikipedia.org)
Palmitoleoylation is an acylation type where the monounsaturated fatty acid palmitoleic acid is covalently attached to serine or threonine residues of proteins. (wikipedia.org)
Histones H3.1, H3.2 and H3.3 were demonstrated to be modified with fatty acid chemical reporters on the conserved cysteine 110, a novel site of S-acylation on histone H3.2. (rockefeller.edu)
Wilson, John P., "Bioorthogonal Chemical Reporters Reveal Fatty-Acylation of Histone H3 Variants and Cholesterol Modification of Proteins and Trafficking in Cells" (2011). (rockefeller.edu)
It may be related to changes in fatty acylation of platelet structural proteins. (medscape.com)
Proteins5
Scientists have reported that in viruses such as SARS-CoV-1 and mouse hepatitis virus (MHV), both S and E proteins undergo S-acylation. (news-medical.net)
S-acylation is regarded as a hallmark of viral envelope proteins. (news-medical.net)
It has also characterized Spike acylation and has also identified other acylated viral proteins and host enzymes involved in the process of infection. (news-medical.net)
Researchers have also studied how S-acylation modifies the turnover rate of proteins. (news-medical.net)
This suggests that ERECTA S-acylation occurred when ERECTA emerged during the evolution of angiosperms and may have contributed to the neo-functionalisation of ERECTA from ERECTA-like proteins. (st-andrews.ac.uk)
While studying the importance of these cysteine residues, researchers found that these are targets of S-acylation and lipidation of those closest to the membrane required to bring the distal cysteines closer to the membrane, making it more accessible to the ZDHHC active site. (news-medical.net)
This suggests that S-acylation of receptor-like kinases at this site is likely the result of chance mutation leading to cysteine occurrence. (st-andrews.ac.uk)
As transmembrane domains followed by cysteine residues are common motifs for S-acylation to occur, and many S-acyl transferases appear to have lax substrate specificity, we propose that many receptor-like kinases are fortuitously S-acylated once chance mutation has introduced a cysteine at this site. (st-andrews.ac.uk)
Pays, E. / A role for the dynamic acylation of a cluster of cysteine residues in regulating the activity of the glycosylphosphatidylinositol- specific phospholipase C of Trypanosoma brucei . (itg.be)
Cytosolic1
N-glycosylation, also occur on their luminal domains and S-acylation on the cytosolic domains. (news-medical.net)
Esterification1
They also show diversified specificity for substrates and reactions under anhydrous conditions to synthesize new molecules by esterification, alcoholysis, transesterification and acylation. (novozymes.com)
Chemistry2
In chemistry, acylation is a broad class of chemical reactions in which an acyl group (R−C=O) is added to a substrate. (wikipedia.org)
The term acylation is studied deeply in the subject of chemistry. (whatismeaningof.com)
Acyl group1
The meaning of the term acylation is that it is a process of adding an acyl group to a compound. (whatismeaningof.com)
Acetic3
Their ability to catalyze the acylation of ethanol with acetic anhydride at 303K has been proven. (niscpr.res.in)
Determining the theoretical optimal conditions for the acylation of para-(1-methylcyclohexyl) phenol with acetic acid creates the basis for evaluating the prospects of this process. (neftemir.ru)
For the carring out the acylation process, para-(1-methylcyclohexyl) phenol (AP) and acetic acid (AcOH) were used as a feedstock. (neftemir.ru)
Alkylation1
Acylation can be used to prevent rearrangement reactions that would normally occur in alkylation. (wikipedia.org)
Membrane1
S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity. (news-medical.net)
Determination1
Test kit for determination of the optimum acylation. (gwb.ee)
Organic1
The authors have developed an approach to the synthesis of a number of N-acylated amino-9,10-anthraquinones, which is based on the use of a new acylation system consisting of a strong organic acid and ammonium thiocyanate. (edu.ua)
Biological1
However, little is known about the role that the type of FA used for acylation plays in the biological action of ghrelin. (uni-luebeck.de)
Role3
A new study published on the bioRxiv * server focuses on the role of S-acylation in the SARS-CoV-2 infection cycle. (news-medical.net)
Here we examine the role of S-acylation adjacent to the transmembrane domain of the plant pathogen perceiving receptor-like kinase FLS2. (st-andrews.ac.uk)
Interestingly some receptor-like kinases show conservation of S-acylation sites between orthologues suggesting that S-acylation has come to play a role and has been positively selected for during evolution. (st-andrews.ac.uk)
Study1
The MSA format therefore allows direct and real-time fluorescence-based measurement of acylation and represents a powerful alternative technique in the study of N-lipidation. (imperial.ac.uk)
Conditions1
It was shown that certain FC-reactive aromatics could be effectively functionalized by FC acylations carried out under ball-milling conditions without the presence of a solvent. (irb.hr)
Common1
Expanding this analysis to the wider plant receptor-like kinase family we find that S-acylation adjacent to receptor-like kinase domains is common, affecting ~25% of Arabidopsis receptor-like kinases, but poorly conserved between orthologues through evolution. (st-andrews.ac.uk)
Research1
Thereby, this research shows acylation is vital for efficient Spike biogenesis. (news-medical.net)
Found2
Additionally, we found that acylation of ghrelin with a long-chain FA (C16) delays the acute central stimulation of food intake. (uni-luebeck.de)
Lastly, we found that, depending on acylation length, systemic and central chronic actions of ghrelin on adiposity can be enhanced or reduced. (uni-luebeck.de)
Products1
A highly enantioselective acylation of silyl ketene acetals with acyl fluorides was developed to generate useful α,α-disubstituted butyrolactone products in high yield and excellent enantioselectivities. (harvard.edu)