• Mutations
  • Germline mutations of ACVRL1 are associated with: hereditary hemorrhagic telangiectasia type 2 (Rendu-Osler-Weber syndrome 2) Pulmonary arteriovenous malformations Somatic mosaicism in ACVRL1 are associated with severe pulmonary arterial hypertension. (wikipedia.org)
  • follistatin
  • Animals lacking myostatin or animals treated with substances such as follistatin that block the binding of myostatin to its receptor have significantly larger muscles. (wikipedia.org)
  • The activin-binding protein follistatin is produced by folliculostellate (FS) cells of the anterior pituitary. (wikipedia.org)
  • In the tissues activin has a strong role in cellular proliferation, thereby making follistatin the safeguard against uncontrolled cellular proliferation and also allowing it to function as an instrument of cellular differentiation. (wikipedia.org)
  • In the blood, activin and follistatin are both known to be involved in the inflammatory response following tissue injury or pathogenic incursion. (wikipedia.org)
  • transcriptional
  • The transcriptional factor p38 activation induced by GDF2 has been documented in other cell types such as osteosarcoma cells, human osteoclasts derived from cord blood monocytes, and dental follicle stem cells. (wikipedia.org)
  • ACVR1C
  • ACVR1C is dispensable for mouse embryogenesis, which suggests alternative functions for this receptor in postnatal development and tissue homeostasis. (acris-antibodies.com)
  • ACVR1C plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca2+ signaling. (acris-antibodies.com)
  • ACVR1C is a type I receptor for the TGFB family of signaling molecules. (wikipedia.org)
  • paracrine
  • These cells are responsive to both autocrine and paracrine activin B signaling, which controls their proliferation. (wikipedia.org)
  • Its primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a particular focus on activin, a paracrine hormone. (wikipedia.org)
  • Inhibitor
  • Molecular docking simulation based in-silico virtual screening technique is used in current experimental study for developing potent inhibitor molecules for activin receptor type IIB of humans for treatment of anaemia. (alliedacademies.org)
  • pathway
  • The activation of this pathway has been documented in all cellular types analyzed up to date, including hepatocytes and HCC cells. (wikipedia.org)
  • Little is known about this type of pathway in GDF2. (wikipedia.org)
  • This enzyme participates in 7 metabolic pathways: MAPK signaling pathway, cytokine-cytokine receptor interaction, TGF beta signaling pathway, adherens junction, colorectal cancer, pancreatic cancer, and chronic myeloid leukemia. (wikipedia.org)