Activation analysis. Medical search. Frequent questions

A hyperinflammatory 'cytokine storm' state termed macrophage activation syndrome (MAS), culminating from a complex interplay of genetics, immunodeficiency, infectious triggers and dominant innate immune effector responses, can develop across disparate entities including systemic juvenile idiopathic arthritis (sJIA) and its counterpart adult-onset Still disease (AOSD), connective tissue diseases, sepsis, infection, cancers and cancer immunotherapy. (nature.com)
Although macrophage activation syndrome (MAS) is often termed autoinflammatory in both loss and gain of function phenotypes, adaptive lineage cells, especially T cells, are clearly important in both settings. (nature.com)
To develop criteria for the classification of macrophage activation syndrome (MAS) in patients with systemic juvenile idiopathic arthritis (JIA). (bmj.com)
To understand if polarization of macrophages can lead to a procoagulant macrophage subset we polarized human monocyte derived macrophages to a proinflammatory and an alternative activation state. (haematologica.org)
This macrophage polarization can be simulated in vitro using lipopolysaccharide (LPS) and interferon (IFN)-γ stimulation for a proinflammatory subset termed classical activation and stimulation with interleukin (IL)-4 and IL-13 for an alternative polarization phenotype. (haematologica.org)
Compared with controls, the detectable proportion of HIV-1 particles derived from CD14 macrophages and CD26 lymphocytes was increased in persons with acute malaria coinfection and correlated with markedly increased plasma concentrations of both proinflammatory cytokines and soluble markers of macrophage and lymphocyte activation. (lww.com)
Parasite clearance following treatment with antimalarial drugs resulted in decreased detection of HIV-1 particles derived from the CD14 macrophage cell subset and correlated with a marked diminution in systemic immune activation. (lww.com)
This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome and hemophagocytic lymphohistiocytosis, which are characterized by macrophage and T-cell activation. (cdc.gov)
An evaluation of 2 cohorts of patients with EVD revealed that a marker of macrophage activation (sCD163) but not T-cell activation (sCD25) was associated with severe and fatal EVD. (cdc.gov)
These data suggest that host macrophage activation contributes to EVD pathogenesis and that directed antiinflammatory therapies could be beneficial in the treatment of EVD. (cdc.gov)
Hypercytokinemia accompanied by severe clinical disease seen in EVD is reminiscent of what has been described for macrophage activation syndrome (MAS) and hemophagocytic lymphohistiocytosis (HLH). (cdc.gov)
Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic disease that, for unknown reasons, occurs much more frequently in individuals with systemic juvenile idiopathic arthritis (SJIA) and in those with adult-onset Still disease. (medscape.com)
[ 1 , 2 ] Macrophage activation syndrome is characterized by pancytopenia, liver insufficiency, coagulopathy, and neurologic symptoms and is thought to be caused by the activation and uncontrolled proliferation of T lymphocytes and well-differentiated macrophages, leading to widespread hemophagocytosis and cytokine overproduction. (medscape.com)
Typically, patients with macrophage activation syndrome become acutely ill with the sudden onset of nonremitting high fever, profound depression in all 3 blood cell lines (ie, leukopenia, anemia, and thrombocytopenia), hepatosplenomegaly, lymphadenopathy, and elevated serum liver enzyme levels. (medscape.com)
The treatment of macrophage activation syndrome is traditionally based on the parenteral administration of high doses of corticosteroids. (medscape.com)
Macrophage activation syndrome is characterized by a highly stimulated but ineffective immune response. (medscape.com)
Recent studies have shown that MUNC 13-4 polymorphisms are associated with macrophage activation syndrome in some patients with SJIA. (medscape.com)
Through mechanisms that have not yet been well elucidated, this impairment in cytotoxic function leads to an excessive expansion and activation of cytotoxic cells, with hypersecretion of proinflammatory cytokines such as interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10, and macrophage-colony-stimulating factor (M-CSF). (medscape.com)

Neutron activation analysis (NAA) is a nuclear process used for determining the concentrations of elements in many materials. (wikipedia.org)
If NAA is conducted directly on irradiated samples it is termed instrumental neutron activation analysis (INAA). (wikipedia.org)
this technique is known as radiochemical neutron activation analysis (RNAA). (wikipedia.org)
Neutron activation analysis is a sensitive multi-element analytical technique used for both qualitative and quantitative analysis of major, minor, trace and rare elements. (wikipedia.org)
Title : Neutron activation analysis Personal Author(s) : Seal, Morgan S.;Mills, William A.;Terrill, James G. (cdc.gov)
1957). Neutron activation analysis. (cdc.gov)

Induction of hypoxia was confirmed by flow cytometric analysis and the levels of SIRT1 were noted in a hypoxic condition as well in the cells after blocking SIRT1 activity using sirtinol. (molvis.org)
Hypoxic induction was confirmed using flow cytometric analysis, which showed cell cycle arrest starting at a 200 µM concentration of cobalt chloride. (molvis.org)
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis . (biolegend.com)

Using single molecule Total Internal Reflection Fluorescence (TIRF) Microscopy, we determined the mechanism controlling membrane localization of PI3Kβ, prioritization of signaling inputs, and lipid kinase activation. (elifesciences.org)
Although much is known about the activation of escape circuitry by the primary afferent inputs that signal approach of predators, such as acoustic,acousticolateralis, visual and mechanosensory inputs, far less is known about how the same circuits are engaged by abiotic stressors such as high or low temperature, or anoxia. (biologists.com)

In this study, I further unraveled the molecular mechanism of mDia activation in TCR signaling. (nii.ac.jp)
The manuscript describes the synergy among PI3Kβ activators, providing compelling results concerning the mechanism of their activation. (elifesciences.org)
The molecular mechanism of channel activation is still unknown. (nature.com)
Here we analyze the complex activation mechanism of homotetrameric HCN2 channels by confocal patch-clamp fluorometry and kinetically quantify all ligand binding steps and closed-open isomerizations of the intermediate states. (nature.com)
Banks, M.I., Pearce, R.A. & Smith, P.H. Hyperpolarization-activated cation current ( I h) in neurons of the medical nucleus of the trapezoid body: voltage-clamp analysis and enhancement by norepinephrine and cAMP suggest a modulatory mechanism in the auditory brain system. (nature.com)
The mechanism of early activation of GP IIb/IIIa receptors in diabetic conditions remains unknown. (aging-us.com)
This suggests that the mechanism of platelet activation in the diabetic state has not been fully elucidated. (aging-us.com)
Scatchard plot analysis revealed one binding mechanism with a Kd value of 7 × 107 M. Conversion of H. pylori cell-bound plasminogen to plasmin in the presence of a tissue-type plasminogen activator was demonstrated by digestion of the chromogenic substrate S-2251. (lu.se)

The activation likelihood estimation (ALE) was used, which is a quantitative voxel based meta-analysis method which can be used to estimate consistent activations across different imaging studies. (bmj.com)
C57BL/6J (B6) XY gonads showed a consistent ~5-hour delay in the activation of most male pathway genes and repression of female pathway genes relative to 129S1/SvImJ, which likely explains the sensitivity of the B6 strain to male-to-female sex reversal. (mdc-berlin.de)
The high conduction velocity of this initial burst is consistent with the activation of a Mauthner neuron, one of a pair of giant reticulospinal neurons in fish and amphibians. (biologists.com)

Lymphocyte activation gene 3 (LAG-3/CD223) is a CD4 homolog known to be selectively expressed in activated T and NK cells. (nih.gov)

The distinct MAS phenotype that arises with hypercytokinaemia can be explained by activation of macrophages that are closely juxtaposed to sinusoids that permit direct phagocytic access to haematopoietic lineage cells. (nature.com)
Acute P. falciparum malaria coinfection impacts virus-host dynamics in HIV-1-infected persons at the cellular level, notably showing a reversible induction of HIV-1 replication in CD14 macrophages that is associated with changes in immune activation. (lww.com)

Inflammation contributed to foam cell formation in the radial arteries of ESRD patients via activation of the CXCL16/CXCR6 pathway, which may be regulated by P2X7R. (medsci.org)
However, the ultimate common pathway of platelet aggregation is the activation of glycoprotein (GP) IIb/IIIa receptors present on platelet surface [ 7 - 9 ]. (aging-us.com)
Chronic stress leads to the activation of the beta- adrenergic pathway. (bvsalud.org)
The aim of this study was to investigate the influence of the beta- adrenergic pathway activation in the progression of HNSCCs, assess its impact in the survival of the patients , and explore the potential targets. (bvsalud.org)

Differentially expressed genes (DEGs) were identified through differential expression analysis . (bvsalud.org)
Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization. (medlineplus.gov)

To address this, we conducted an activation likelihood estimation (ALE) meta-analysis on within-group data from older adults and young adults performing regularly paced right-hand finger movement tasks in response to external stimuli. (nih.gov)

Abstract:A combination of mechanical activation and Differential Thermal Analysis (DTA) together with X-Ray Diffraction (XRD), and various microstractural characterization techniques were used to evaluate the starting reaction in the combustion synthesis of TiC-Al2O3 composite in TiO2-Al-C system. (ac.ir)

The purpose of this study is to examine the spatial frequency spectrum of epicardial activation time sequences computed by common activation detection algorithms, determine which algorithm is least noisy, and derive the recording site density necessary to avoid distortion of the epicardial activation map. (duke.edu)
Anomalous activation times from serially adjacent bipolar electrograms, which constitute algorithm noise, were studied. (duke.edu)
Of the bipolar algorithms, the Morphological algorithm produced the fewest anomalous activation times. (duke.edu)
This activation algorithm is designed in such a way that the sensor dynamically computes its sleep interval according to additive increase and multiplicative decrease, based on its current energy level. (wichita.edu)

The role of SIRT1 in the activation of HIF-2α and nuclear factor-κB (RelA/p65) during hypoxia in the presence or absence of SIRT1 was assessed using immunoblot analysis. (molvis.org)
Immunoblot analysis identified two plasminogen binding proteins of 57 and 42 kDa. (lu.se)

Qin R , Zhu H , Wang F , Song M , Lin P , Xing Y , Zhang W , Zhong M , Wang Z , . Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation. (aging-us.com)
GP IIb/IIIa receptor activation plays an important role in thrombosis. (aging-us.com)

However, diabetic patients have significantly higher platelet aggregation and activation than non-diabetic patients, including those undergoing dual antiplatelet therapy [ 4 - 6 ]. (aging-us.com)

Based on this analysis and evaluation, in data stream mining evaluation, FIMT-DD-tanh could be able to decrease the error value in airline big dataset. (ui.ac.id)

To elucidate the first steps of sexual fate specification, we profiled the XX and XY gonad transcriptomes at fine granularity during this period and resolved cascades of gene activation and repression. (mdc-berlin.de)
They also express the immediate early gene c-FOS, a molecular marker indicative of intense neural activation, at the time of the OVX+E±progesterone-evoked LH surge. (jneurosci.org)

We hypothesized that older adults would show a greater likelihood of activation in right cortical motor areas (i.e., ipsilateral to the side of movement) compared to young adults. (nih.gov)
Methods The present study is a quantitative meta-analysis of the current VBM findings aimed at delineating the cortical regions with consistently increased or reduced GM concentrations. (bmj.com)

Although GABA activates synaptic (αβγ) GABA A receptors with high efficacy, partial agonist activation of αβγ isoforms and GABA activation of the primary extrasynaptic (αβδ) GABA A receptors are limited to low-efficacy activity, characterized by minimal desensitization and brief openings. (jneurosci.org)
In conclusion, EMP-PDI promotes early platelet activation through glycoprotein (GP) IIb/IIIa receptors present on platelet surface in the diabetic state. (aging-us.com)

High level skills with quantitative and qualitative research and analysis and report writing. (acfid.asn.au)

To evaluate whether kisspeptin and/or GPR54 were essential for GnRH neuron activation and the LH surge, Gpr54 - and Kiss1 -null mice were examined. (jneurosci.org)
These observations provide the first evidence that kisspeptin-GPR54 signaling is essential for GnRH neuron activation that initiates ovulation. (jneurosci.org)

Until the introduction of ICP-AES and PIXE, NAA was the standard analytical method for performing multi-element analyses with minimum detection limits in the sub-ppm range. (wikipedia.org)
However, because of noise intrinsic in activation detection algorithms, closer recording sites may be required than those theoretically computed. (duke.edu)

In this study, we investigate the Toll-like receptor 4 (TLR4) activation of the major birch and grass pollen allergens Bet v 1 and Phl p 5, and how the physiological oxidant peroxynitrite (ONOO - ) changes the TLR4 activation through protein nitration and the formation of protein dimers and higher oligomers. (frontiersin.org)
Further analysis showed that protein expression of CXCL16, CXCR6, disintegrin and metalloproteinase-10 (ADAM10) in the radial arteries of the inflamed group was significantly increased. (medsci.org)
Actin-related protein 2/3 (Arp2/3) complex activation by nucleation promoting factors (NPFs) such as WASP, plays an important role in many actin-mediated cellular processes. (elifesciences.org)
The purpose of this study was to investigate the release of Endothelial microparticle (EMP)-associated protein disulfide isomerase (PDI) after endothelial cell injury induced in diabetes and the changes in platelet activation. (aging-us.com)

Combined Computational and Experimental Study on [5 + 2] Cycloaddition of 2-Trifluoromethylated Oxidopyrylium Species Leading to 1-(Trifluoromethyl)-8-oxabicyclo[3.2.1]oct-3-en-2-ones. (acs.org)

The mechanical activation was performed on the mixtures of two components of TiO2/Al, Al/C and TiO2/C and then the third component was added according to the stoichiometric reaction for 3TiC+2Al2O3 composite formation. (ac.ir)
On the contrary, the mechanical activation of Al/C and TiO2/C mixtures for 16 hr made the reaction temperature increase to 995 °C and 1024 °C, respectively. (ac.ir)

The possibility of using neutron activation analyses to differentiate sources of North American waterfowl was investigated by irradiating rectrices and wing bones of birds collected in several localities, and comparing the characteristic gamma-ray spectra. (usgs.gov)
Additional Possibility of Data Analysis of Enzyme Inhibition and Activation 2. (scialert.net)
Additional possibility of data analysis of enzyme inhibition and activation.1: Equations for calculation of the k a and k i constants of enzyme activation and nontrivial types of enzyme inhibition. (scialert.net)

Coordinate correction for calculating the constants of enzyme activation and inhibition. (scialert.net)
Applicability of vector presentation of enzymatic reactions to the analysis of enzyme activation and inhibition. (scialert.net)

To analyze the time required to dissolute the pulp tissue under different methods of sodium hypochlorite activation. (bvsalud.org)

Figure 3: Fit of ligand binding and activation by a Markovian state model. (nature.com)

This complex interaction of the subunits leads to a preferential stabilization of states with zero, two or four ligands and suggests a dimeric organization of the activation process: within the dimers the cooperativity is positive, whereas it is negative between the dimers. (nature.com)

How does the single unit monomer insertion technique promote kinetic analysis of activation and initiation in photo-RAFT processes? (rsc.org)
In thrombosis, platelet activation serves as the initiation factor. (aging-us.com)

Large global mapping systems or regionally dense arrays may offer advantages during catheter ablations for ventricular tachycardia and for studies into the mechanisms of ventricular tachycardia by accurately defining the cardiac activation pattern. (duke.edu)
This averaging effect hampered the analysis of finer regulatory mechanisms at the single-cell level, the fundamental unit for any fate decision process. (lu.se)

Its activation has been implicated in the progression of different types of cancer but its role on head and neck squamous cell carcinomas (HNSCCs) remains undefined. (bvsalud.org)

As B cells express LAG-3 in a T cell dependent manner and not when activated by Toll-like-receptor agonists alone, we propose LAG-3 as a new marker of T cell induced B cell activation. (nih.gov)

Immune activation and induction of HIV-1 replication within. (lww.com)
To determine the impact of Plasmodium falciparum malaria coinfection and its treatment on cellular reservoirs of viral replication in HIV-1-infected persons and to relate this to changes in systemic immune activation. (lww.com)
Immunomagnetic HIV-1 capture analysis was used to determine the cellular origin of cell-free virus particles present in all 30 plasma samples and indices of immune activation were measured using enzyme-linked immunosorbent assays. (lww.com)

Compared with the normal diet group, the diabetic group had significantly increased plasma EMP-PDI content and accelerated platelet activation by increased GP IIb/IIIa expression. (aging-us.com)

A multistep process, based on a combination of expert consensus and analysis of real patient data, was conducted. (bmj.com)
We investigated the issue of homotopic co-activations in women and men using a coordinate-based meta-analytic method and data from the BrainMap database. (springer.com)
Oracle Activation features a full suite of audience data solutions and contextual targeting technology to help you reach the right people, target high-impact environments, protect ad spend, and strengthen brand safety protocols. (oracle.com)
What is data activation? (oracle.com)

Density functional theory calculation was performed to study the photo-activation and radical-monomer addition steps, implying that the reaction energies of these two steps are highly influenced by the penultimate units but in the opposite ways. (rsc.org)
Functional analysis of an ADAMTS10 signal peptide mutation in Weill-Marchesani syndrome demonstrates a long-range effect on secretion of the full-length enzyme. (medlineplus.gov)

2008 ). Indeed, previous work from our group adopted a meta-analytical framework to evaluate the homotopic co-activation patterns (Mancuso et al. (springer.com)

By the addition of KOH, chemical activation of the materials is induced during carbonization, producing Pickering-emulsion-templated carbon foams, or carboHIPEs, with tailorable macropore diameters and surface areas almost triple that of those previously reported. (mdpi.com)

Most importantly, it is believed that an increase in free radical production, intracellular calcium overload, and excessive activation of inflammatory response are cumulatively responsible for IRI. (frontiersin.org)

also known as the distortion/interaction model), wherein the ASA is utilized for the analyses of entire molecular dynamics trajectories. (readthedocs.io)

Implementing a series of sampling procedures to equalize the size and proportion of the datasets, our results indicated that females exhibit stronger interhemispheric co-activation than males, suggesting that the female brain is less lateralized and more integrated than that of males. (springer.com)

Using mouse models, the present study addressed whether kisspeptin and GPR54 have a key role in the activation of GnRH neurons to generate the luteinizing hormone (LH) surge responsible for ovulation. (jneurosci.org)
This article by NIOSH describes a study in which gold mine dust samples underwent gravimetric analysis, quantification of silica, and characterization via aerodynamic and scanning mobility particle sizers. (cdc.gov)

Given a model and an input to the model, compute the total number of activations of the model. (readthedocs.io)
model ( nn.Module ) - The model to compute activation counts. (readthedocs.io)

However, kinetic analysis is still less explored due to its inherent complexity in RAFT processes and photochemistry. (rsc.org)

In addition, males appear to show less intense but more extensive co-activation than females. (springer.com)

These design features include the involvement of relatively large neurons that conduct neural information rapidly, but that have a relatively high threshold for activation. (biologists.com)

A particular advantage of this technique is that it does not destroy the sample, and thus has been used for the analysis of works of art and historical artifacts. (wikipedia.org)
Analyses and sample location maps were compiled from stream sediment, panned concentrate, soil, and rock samples. (cdc.gov)
if a sufficient sample amount was available, serum chemistry analyses were also performed. (cdc.gov)
range: 6-15 months), investigators replaced conventional phlebotomy devices with safety devices hospitalwide, monitored supplies of phlebotomy equipment to attempt to ensure that only safety devices were available, continued enhanced surveillance for injuries, and inventoried the autoclaved contents of a representative sample of disposal containers for sharp instruments to determine rates of use of safety devices and conventional devices and rates of activation of safety features. (cdc.gov)

This last procedure was realized with the aid of prosodic analysis software. (bvsalud.org)

Hypoxia of CEC was induced by exposing the cells to cobalt chloride (Sigma-Aldrich, St. Louis MO) in serum media, as described previously [ 12 , 13 ], and the induction was confirmed by cytotoxicity and cell cycle analysis. (molvis.org)

Activation time sequences were analyzed using conventional Fourier techniques. (duke.edu)

Anatomy2

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes1

Technology, Industry, Agriculture1

Macrophage18

Neutron activati6

Flow cytometric analysis3

Inputs2

Mechanism8

Consistent3

Lymphocyte Activation1

Macrophages2

Pathway4

Genes2

Likelihood estimation1

Abstract1

Algorithm4

Immunoblot2

Receptor activation2

Patients1

Evaluation1

Gene2

Cortical2

Receptors2

Quantitative1

Neuron2

Detection2

Protein4

Computational1

Mechanical activation2

Possibility3

Inhibition2

Methods1

Ligand1

Organization1

Initiation2

Mechanisms2

Progression1

Marker1

Immune3

Expression1

Data4

Functional2

Patterns1

Chemical1

Excessive1

Distortion1

Brain1

Study2

Model2

Processes1

Intense1

Involvement1

Sample4

Procedure1

Induction1

Conventional1