• It may be associated with other anomalies, like craniofacial anomalies (cleft lip and/or cleft palate, optic atrophy, low set ears, acrocephalosyndactylia and facial bone anomalies), gastrointestinal anomalies, cardiovascular anomalies, skeletal anomalies, genitourinary anomalie. (jpgo.org)
  • Reproductive fitness is low, and more than 98% of cases arise by new mutation.The syndrome is named for the French physician who described the syndrome acrocephalosyndactylia in 1906. (medscape.com)