• In addition to osteolysis of the distal phalanges, these patients have a generalized osseous dysplasla with osteoporosis, premature loss of teeth , short stature and a distinctive facial appearance. (symptoma.com)
  • Acro-osteolysis of the distal phalanges has been reported. (binaryoptionstradinglist.com)
  • MADB is characterized by brittle hair, mottled, atrophic skin, generalized lipodystrophy, insulin resistance, metabolic complications and skeletal features like stunted growth, mandibular and clavicular hypoplasia and acro-osteolysis of the distal phalanges. (biomedcentral.com)
  • When acro-osteolysis is accompanied by generalized OSTEOPOROSIS and skull deformations, it is called HAJDU-CHENEY SYNDROME. (harvard.edu)
  • Background: Hajdu-Cheney syndrome (HCS) is a rare autosomal dominant condition characterized by osteoporosis, acro-osteolysis, short stature and specific craniofacial features and is caused by mutations in the NOTCH2 gene which codes for a single-pass transmembrane protein that plays a critical role in skeletal development and bone remodelling. (eurospe.org)
  • Pamidronate does not improve peripheral osteolysis in multicentric osteolysis and nodular arthropathy caused by a mutation in the matrix metalloproteinase 2 gene. (medscape.com)
  • Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome. (medscape.com)
  • Intensified symptoms of osteoporosis, including osteolysis of the carpal and tarsal bones, causes destructive changes in the joints of the hands and wrists, as well as in the joints of the tarsus and foot. (medscape.com)
  • Definition A rare, autosomal dominant skeletal disorder characterized by the association of facial anomalies, acro-osteolysis, general osteoporosis, insufficient ossification of the skull, and periodontal disease (premature loss of permanent teeth). (symptoma.com)
  • In the case of long-standing clubbing, bone remodeling can cause osseous resorption at the terminal phalanges of the fingers and toes, which is termed acro-osteolysis. (medscape.com)
  • Loss of bone tissue from the hands and feet (acro-osteolysis) is a characteristic feature of the condition. (medlineplus.gov)
  • Many of the disorder's features, such as acro-osteolysis and some of the characteristic facial features, are not present at birth but become apparent in childhood or later. (medlineplus.gov)
  • Mandibuloacral dysplasia (MAD) is a rare disorder combining a characteristic facial appearance with acro-osteolysis and lipodystrophy. (bmj.com)
  • Patient had 12 y history of poor wound healing refractory to immunosuppressive treatment, connective tissue disease (scleroderma) and bilateral acro-osteolysis with amputated digits. (cdc.gov)
  • Acroosteolysis is resorption of the distal bony phalanges. (wikipedia.org)
  • Note the soft-tissue clubbing and acro-osteolysis of the terminal phalanges. (medscape.com)
  • Osteolysis is understood in medicine as an active dissolution of bone tissue. (photionary.com)
  • In moderation, osteolysis is therefore a physiological process within the framework of normal bone remodeling, which reduces bone tissue that is no longer under load and thus adapts it to its functional requirements. (photionary.com)
  • This graph shows the total number of publications written about "Acro-Osteolysis" by people in Harvard Catalyst Profiles by year, and whether "Acro-Osteolysis" was a major or minor topic of these publication. (harvard.edu)
  • HCS is characterized by craniofacial developmental defects, including platybasia and wormian bones, osteoporosis with fractures, and acro-osteolysis. (nih.gov)
  • Intensified symptoms of osteoporosis, including osteolysis of the carpal and tarsal bones, causes destructive changes in the joints of the hands and wrists, as well as in the joints of the tarsus and foot. (medscape.com)
  • There is progressive focal bone destruction, including acroosteolysis and generalized osteoporosis. (nih.gov)
  • Many of the disorder's features, such as acro-osteolysis and some of the characteristic facial features, are not present at birth but become apparent in childhood or later. (medlineplus.gov)
  • The phenomenon of acro-osteolysis often intrigues clinicians and patients alike, as it causes bone resorption. (nih.gov)
  • Les deux patients ont bénéficié d'une prise en charge en milieu hospitalier. (jomos.org)