The treatment response of serum TRACP5b activity, bone alkaline phosphatase (BAP) activity, and concentrations of NH2-terminal telopeptide of type 1 collagen (NTX) in 68 breast cancer patients with bone metastasis were determined. (tmu.edu.tw)
The purpose of this study was to investigate the activities of the total acid phosphatase (TAP), tartrate-resistant acid phosphatase (TRAP), low molecular weight protein tyrosine phosphatase (LMW-PTP) and alkaline phosphatase (ALP) enzymes, as well as the possible correlation in the serum and in unstimulated whole saliva of children. (bvsalud.org)
Protein18
A protein complex which is capable of acid phosphatase activity. (mcw.edu)
Tartrate-resistant acid phosphatase (TRAP) is a basic iron-binding protein with high activity towards phosphoproteins, ATP and 4-nitrophenyl phosphatase. (thermofisher.com)
SA directly binds to A subunits of protein phosphatase 2A (PP2A), inhibiting activity of this complex. (ugent.be)
Salicylic acid targets protein phosphatase 2A to attenuate growth in plants," CURRENT BIOLOGY , vol. 30, pp. 381-395, 2020. (ugent.be)
Human Umbilical Cord Mesenchymal Stem Cell-induced Osterix, Bone Morphogenetic Protein-2, and Tartrate-resistant Acid Phosphatase Expression in Osteoporotic Mandibular Bone. (physiciansweekly.com)
The aim of this study was to prove that human umbilical cord mesenchymal stem cell (hUCMSC) therapy conducted according to the mandibular osteoporotic model will increase Osterix (Osx) and bone morphogenetic protein-2 (BMP-2) expression, while reducing tartrate-resistant acid phosphatase (TRAP) expression. (physiciansweekly.com)
1. Sharief FS, Lee H, Leuderman MM, Lundwall A, Deaven LL, Lee CL, Li SS (1989) Human prostatic acid phosphatase: cDNA cloning, gene mapping and protein sequence homology with lysosomal acid phosphatase. (nordicmubio.com)
2. Veeramani S, Yuan TC, Chen SJ, Lin FF, Petersen JE, Shaheduzzaman S, Srivastava S, MacDonald RG, Lin MF (2005) Cellular prostatic acid phosphatase: a protein tyrosine phosphatase involved in androgen-independent proliferation of prostate cancer. (nordicmubio.com)
A genetically-engineered protein formed by the fusion of prostatic acid phosphatase (PAP) and sargramostim (GM-CSF). (medicalterminologydb.com)
Vaccination with antigen-presenting cells (APC) loaded with prostatic acid phosphatase-sargramostim fusion protein may elicit a cytotoxic T-cell response against tumor cells that express PAP. (medicalterminologydb.com)
The ACP5 gene mutations that cause SPENCDI typically change single protein building blocks (amino acids) in the TRAP enzyme or result in the production of an abnormally short enzyme. (medlineplus.gov)
Although intracellular signal transduction is often portrayed as a protein kinase 'domino effect', the counterbalancing function of phosphatases, and thus the control of phosphatase activity, is equally relevant to proper regulation of cellular function. (ac.be)
Protein Phosphatase 2A (PP2A) is a widely expressed family of protein phosphatases made of a core dimer, composed of a catalytic (C) subunit and a structural (A) subunit, in association with a third variable regulatory (B) subunit. (ac.be)
Although viewed as a constitutive housekeeping enzyme in the past, PP2A is a highly regulated phosphatase and is emerging as an important regulator of multiple cellular processes involving protein phosphorylation. (ac.be)
In the past, most of the attention was focused primarily on protein kinases and on their regulation, mainly because phosphatases were then viewed as simple housekeeping enzymes. (ac.be)
But advances in the understanding of protein phosphatases make now clear that these enzymes are precisely regulated and are as important as kinases in the regulation of cellular processes involving protein phosphorylation. (ac.be)
2 Protein phosphatase 2A (PP2A) is a very abundant - it accounts for as much as 1% of total cellular proteins - ubiquitous and remarkably conserved enzyme. (ac.be)
Serum4
Different forms of acid phosphatase are found in different organs, and their serum levels are used to evaluate the success of the surgical treatment of prostate cancer. (wikipedia.org)
In Vitro Diagnostic reagent pack for the determination of acid phosphatase in serum on automated and semi automated analysers. (bioactiva.com)
Prostatic acid phosphatase (PAP), which is produced in the prostate, was the first major serum marker for prostate cancer, and was used widely for screening, staging, and post-treatment monitoring. (medscape.com)
Serum tartrate-resistant acid phosphatase 5b (TRACP5b) activity is a novel bone resorption marker. (tmu.edu.tw)
Phosphate8
Acid phosphatase (EC 3.1.3.2, systematic name phosphate-monoester phosphohydrolase (acid optimum)) is an enzyme that frees attached phosphoryl groups from other molecules during digestion. (wikipedia.org)
Acid phosphatase catalyzes the following reaction at an optimal acidic pH (below 7): a phosphate monoester + H2O = an alcohol + phosphate Phosphatase enzymes are also used by soil microorganisms to access organically bound phosphate nutrients. (wikipedia.org)
Lysophosphatidic acid phosphatase type 6 (ACP6) is an LPA-specific acid phosphatase that hydrolyzes LPA to monoacylglycerol (MAG) and phosphate. (rcsb.org)
Acid phosphatases are enzymes that are capable of hydrolyzing phosphate esters in an acidic environment. (medscape.com)
In a 1.10 mL reaction mix, the final concentrations are 41 mM citric acid, 6.9 mM p-nitrophenyl phosphate, and 0.015-0.025 units of acid phosphatase. (sigmaaldrich.com)
Biologically, PAP exhibits both phosphatase activity and ecto-5 0 -nucleotidase activity, generating extracellular phosphate and adenosine as the final products. (mssm.edu)
Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development. (harvard.edu)
Lysosomal2
A rare lysosomal disease characterized by intermittent vomiting hypotonia lethargy opisthotonos and fatal outcome in early infancy associated with deficient acid phosphatase in lysosomes. (globalgenes.org)
Newly diagnosed with Lysosomal acid phosphatase deficiency? (globalgenes.org)
Enzymes1
The enzymes that dephosphorylate these three amino acids are classified into four groups on the basis of specific catalytic signatures/domain sequences and substrate preference. (ac.be)
Enzyme4
Acid phosphatase is a hydrolytic enzyme secreted by various cells, and it has five isoenzymes. (5minuteconsult.com)
The ACP5 gene provides instructions for making an enzyme called tartrate-resistant acid phosphatase type 5 (TRAP). (medlineplus.gov)
Nouvelles avancées dans la structure et la régulation de la Protéine Phosphatase 2A : les raisons pour lesquelles PP2A ne doit plus être considérée comme une enzyme passive et non spécifique. (ac.be)
Bien que considérée dans le passé comme une enzyme constitutive non spécifique, PP2A est une phosphatase soumise à une régulation précise et qui est importante dans le contrôle des fonctions cellulaires impliquant la phosphorylation. (ac.be)
Assay1
To standardize a procedure for the enzymatic assay of Acid Phosphatase. (sigmaaldrich.com)
Lysophosphatidic acid2
Lysophosphatidic acid (LPA) is an important bioactive phospholipid involved in cell signaling through Gprotein-coupled receptors pathways. (rcsb.org)
Mice homozygous for a hypomorphic allele are viable and fertile with elevated plasma levels of lysophosphatidic acid. (jax.org)
Phospholipid1
Phospholipid Phosphatase 4 promotes proliferation and tumorigenesis, and activates Ca(2+)-permeable Cationic Channel in lung carcinoma cells. (nih.gov)
Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. (nih.gov)
Phosphatidate Phosphatase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Phosphatidate Phosphatase" by people in Harvard Catalyst Profiles by year, and whether "Phosphatidate Phosphatase" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Phosphatidate Phosphatase" by people in Profiles. (harvard.edu)
Tartrate-resistant acid phosphatase (TRAP) and the osteoclast/immune cell dichotomy. (medlineplus.gov)
Deficiency1
Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature. (medlineplus.gov)
Citric acid1
Prepare a 26.5 mg/mL solution in purified water using Citric Acid, Trisodium, Dihydrate, Product No C7254 . (sigmaaldrich.com)
Tartrate resistant5
Tartrate-resistant acid phosphatase may be used as a biochemical marker of osteoclast function during the process of bone resorption. (wikipedia.org)
The following product was used in this experiment: Tartrate Resistant Acid Phosphatase Monoclonal Antibody (5C5E7) from Thermo Fisher Scientific, catalog # MA5-38435, RRID AB_2898349. (thermofisher.com)
These cells are also tartrate resistant and non-specific esterase negative, and are believed to be precursors to osteoclasts and other acid phosphatase positive cells resorbing bone on the trabecular surface. (bmj.com)
Purpose: We investigated whether tartrate-resistant acid phosphatase 5b (TRACP-5b), which is a bone resorption marker, can serve as a valid predictor of stress fractures in female athletes in their teens and 20s. (elsevierpure.com)
Osteoclasts were enumerated after tartrate-resistant acid phosphatase staining. (bvsalud.org)
Activity3
Some plant roots, especially cluster roots, exude carboxylates that perform acid phosphatase activity, helping to mobilise phosphorus in nutrient-deficient soils. (wikipedia.org)
Nature of mononuclear cells positive for acid phosphatase activity in bone marrow of patients with renal osteodystrophy. (bmj.com)
Semen acid- phosphatase activity was increased in the 45mg/kg group. (cdc.gov)
MOLECULAR1
Hydrotropism allows roots to forage for water, a process known to depend on abscisic acid (ABA) but whose molecular and cellular basis remains unclear. (nature.com)
Amino2
11 nonamer peptides derived from the amino acid sequence of PAP were used as stimulator antigens in functional ELISPOT assays with peripheral blood mononuclear cells from 20 HLA-A2+ patients with prostate cancer or ten healthy blood donors. (elsevierpure.com)
4 While proteins can be phosphorylated on nine amino acids, serine, threonine and tyrosinephosphorylation are by far the most predominant in eukaryotic cells. (ac.be)
PP2A1
La Protéine Phosphatase 2A (PP2A) est une phosphatase très abondante composée d'un noyau dimérique contenant une sous-unité catalytique (C) et une sous-unité structurale (A), auquel est associé une sous-unité régulatrice (B) variable. (ac.be)
Tumor1
Prostatic acid phosphatase (PAP) has been investigated as the target of several antigen-specific anti-prostate tumor vaccines. (elsevierpure.com)
Total1
Randox provide high quality Acid Phosphatase reagents, suitable for the detection of both total and non-prostatic acid phosphatase. (labsave.com)
Induction1
Actinomycin d induction of acid phosphatase in synchronized l5178y mouse leukemia cells. (jax.org)
Abstract1
abstract = "A double-antibody radioimmunoassay method for prostate-specific acid phosphatase (PAP) is presented. (johnshopkins.edu)
Human3
3. Graddis TJ, McMahan CJ, Tamman J, Page KJ, Trager JB (2011) Prostatic acid phosphatase expression in human tissues. (nordicmubio.com)