• Inhaled acetylcysteine has been used for mucolytic ("mucus-dissolving") therapy in addition to other therapies in respiratory conditions with excessive and/or thick mucus production. (wikipedia.org)
  • Acetylcysteine is in a class of medications called mucolytic agents. (medlineplus.gov)
  • N-acetylcysteine (NAC) is a mucolytic and nephroprotective agent and is also the antidote to acetaminophen overdose. (jcadonline.com)
  • Although they saw little impact with the most severe group, their progress with other groups led them to conclude that 'acetylcysteine appears to be a useful mucolytic agent in the therapy of cystic fibrosis and is deserving of further clinical trial and evaluation. (rsc.org)
  • Many factors influence the viscosity of mucus, but the sulfhydryl group in acetylcysteine seems to be key to its mucolytic magic. (rsc.org)
  • Acetylcysteine was initially patented in 1960 and came into medical use in 1968. (wikipedia.org)
  • Acetylcysteine was patented in 1960, and just three years later medical doctors Stanley Stamm and Jack Docter presented results at the 87th semi-annual meeting of the North Pacific Paediatric Society on its use in 16 children with cystic fibrosis. (rsc.org)
  • N-acetylcysteine and alpha-lipoic acid improve antioxidant defenses and decrease oxidative stress, inflammation and serum lipid levels in ovariecto. (snip.ly)
  • PAFR was blocked by CV- 3988, and oxidative stress was attenuated by N-acetylcysteine. (cdc.gov)
  • The therapeutic efficacy of oral N-acetylcysteine (NAC) and ambroxol as compared with the effect of placebos was studied in 36 cystic fibrosis (CF) patients with mild to moderate pulmonary disease. (nih.gov)
  • The aim was to review clinical trials that assess the efficacy of N-acetylcysteine in cutaneous disorders. (jcadonline.com)
  • Although IV and oral acetylcysteine are equally effective for this indication, oral administration is generally poorly tolerated due to the higher dosing required to overcome its low oral bioavailability, its foul taste and odour, and a higher incidence of adverse effects when taken by mouth, particularly nausea and vomiting. (wikipedia.org)
  • The most commonly reported adverse effects for IV formulations of acetylcysteine are rash, urticaria, and itchiness. (wikipedia.org)
  • Intravenous and oral formulations of acetylcysteine are available for the treatment of paracetamol (acetaminophen) overdose. (wikipedia.org)
  • However, 3% to 6% of people given intravenous acetylcysteine show a severe, anaphylaxis-like allergic reaction, which may include extreme breathing difficulty (due to bronchospasm), a decrease in blood pressure, rash, angioedema, and sometimes also nausea and vomiting. (wikipedia.org)
  • Repeated doses of intravenous acetylcysteine will cause these allergic reactions to progressively worsen in these people. (wikipedia.org)
  • Several studies have found this anaphylaxis-like reaction to occur more often in people given intravenous acetylcysteine despite serum levels of paracetamol not high enough to be considered toxic. (wikipedia.org)
  • Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure. (rejuvenation-science.com)
  • Acetylcysteine, also known as N-acetylcysteine (NAC), is a medication that is used to treat paracetamol overdose and to loosen thick mucus in individuals with chronic bronchopulmonary disorders like pneumonia and bronchitis. (wikipedia.org)
  • In the treatment of paracetamol (acetaminophen) overdose, acetylcysteine acts to maintain or replenish depleted glutathione reserves in the liver and enhance non-toxic metabolism of acetaminophen. (wikipedia.org)
  • As glutathione is a general-purpose liver protectant, a Cochrane review - a meta-analysis that considers results published from clinical trials and in the scientific literature - has been proposed to see if acetylcysteine may be effective in treating acute liver failure even in the absence of paracetamol poisoning. (rsc.org)
  • Acetylcysteine is also sometimes used to treat people who have taken or received an overdose of acetaminophen (Tylenol, others). (medlineplus.gov)
  • A new retrospective study on the effects of N-acetylcysteine (NAC) on children with acute liver failure not caused by acetaminophen poisoning has found that the treatment was associated with a shorter hospital stay, higher incidence of liver recovery, and better survival after transplantation. (news-medical.net)
  • In a study published in the September issue of Gastroenterology, researchers found that acute liver failure patients in early stages of hepatic comas, when treated with N-acetylcysteine (NAC) , were nearly 2.5 times more likely to survive than those treated only with a placebo. (rejuvenation-science.com)
  • Acetylcysteine inhalation is used along with other treatments to relieve chest congestion due to thick or abnormal mucous secretions in people with lung conditions including asthma, emphysema, bronchitis and cystic fibrosis (an inborn disease that causes problems with breathing, digestion, and reproduction). (medlineplus.gov)
  • Cystic fibrosis aside, acetylcysteine does seem effective at thinning and breaking down mucus. (rsc.org)
  • Research suggests that the rate of liver toxicity is approximately 3% when acetylcysteine is administered within 10 hours of overdose. (wikipedia.org)
  • N -acetylcysteine (NAC) has been used as an antioxidant drug in tumor cells and preclinical mice tumor xenografts, and it improves adaptive immunotherapy in melanoma. (mcw.edu)
  • This study aimed to consider the oxidative damage induced by cadmium (Cd) and apoptosis and the role of N-acetylcysteine (NAC) in preserving hepatic cells against Cd toxicity. (springer.com)
  • Acetylcysteine comes as a solution (liquid) and concentrated solution to inhale by mouth using a nebulizer (machine that turns medication into a mist that can be inhaled). (medlineplus.gov)
  • Acetylcysteine should not be routinely used in a hand bulb operated nebulizer or put directly into a heated nebulizer. (medlineplus.gov)
  • Talk to your doctor or pharmacist about the correct nebulizer to use with acetylcysteine. (medlineplus.gov)
  • N -acetylcysteine (NAC) augmentation of antipsychotic medication is one of very many antipsychotic augmentation strategies that have been studied in schizophrenia. (psychiatrist.com)
  • N-acetylcysteine as a potentially useful medication to prevent conversion to schizophrenia in at-risk individuals. (bvsalud.org)
  • tell your doctor and pharmacist if you are allergic to acetylcysteine, any other medications, or any of the ingredients in acetylcysteine inhalation. (medlineplus.gov)
  • The review of available literature suggests that N-acetylcysteine could potentially serve as a safe, tolerable, and effective therapeutic option for a variety of dermatologic conditions. (jcadonline.com)
  • Only mix acetylcysteine with other medications if instructed to do so by your doctor. (medlineplus.gov)
  • Treatment with N-acetylcysteine (NAC) has been shown to increase levels of glutathione. (nih.gov)
  • Acetylcysteine, given orally or intravenously, seems to maintain or even restore glutathione levels, or may provide an alternative neutralisation pathway - and thus protects the liver. (rsc.org)
  • N-acetylcysteine (NAC) is an amino acid that helps your body to make glutathione. (imofcny.com)
  • N-Acetylcysteine (NAC) is a prodrug for L-cysteine, which is used for the intention of allowing more glutathione to be produced when it would normally be depleted. (meadbery.com)
  • Moreover, N-Acetylcysteine supplements are affordable and readily available. (eternumlabs.com.au)
  • If you decide to take N-Acetylcysteine supplements, be sure to talk to your doctor first to ensure that the dosage is correct. (eternumlabs.com.au)
  • Acetylcysteine may cause side effects. (medlineplus.gov)
  • They discuss their findings in their article, " Antiproliferative Effects of Mitochondria-Targeted N -acetylcysteine and Analogs in Cancer Cells ," published in Scientific Reports . (mcw.edu)
  • OBJECTIVE: Investigated the effects of N-acetylcysteine (NAC) on endoplasmic reticulum stress of sertoli cells induced by sodium fluoride (NaF). (fluoridealert.org)
  • activated charcoal decreases effects of acetylcysteine by Other (see comment). (medscape.com)
  • acetylcysteine increases effects of nitroglycerin IV by Other (see comment). (medscape.com)
  • Comment: Acetylcysteine may enhance vasodilatory effects of nitroglycerin. (medscape.com)
  • Acetylcysteine is used in the treatment of obstructive lung disease as an adjuvant treatment. (wikipedia.org)
  • The jiffy bag was apparently being delivered to Bradley Wiggins and contained fluimucil, a trade name for decongestant drug acetylcysteine - a perfectly legal substance that is not on the World Anti-Doping Agency Prohibited list. (rsc.org)
  • Acetylcysteine is a versatile thiol drug, but one of its other trade names - acetadote - hints at a common use. (rsc.org)
  • The N-acetylcysteine used was supplied by Apothecon/Geneva Pharmaceuticals, a division of Bristol Myers Squibb and Cumberland Pharmaceuticals. (rejuvenation-science.com)
  • Studies that did not show clinical improvement with the administration of N-acetylcysteine, based either on objective or subjective measures, were excluded. (jcadonline.com)
  • Prior pharmacokinetic studies of acetylcysteine did not consider acetylation as a reason for the low bioavailability of acetylcysteine. (wikipedia.org)
  • In recent studies, N-acetylcysteine has been shown to be efficacious in several dermatologic conditions. (jcadonline.com)
  • The concentrated solution of acetylcysteine should be mixed with normal saline or sterile water and used within an hour. (medlineplus.gov)