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  • pharmacokinetics
  • The method was successfully applied for the determination of R and S- acenocoumarol in plasma samples of 28 healthy subjects who participated in a pharmacokinetics study. (scirp.org)
  • Surprisingly, though of its major importance, to date, acenocoumarol detailed pharmacokinetics in human is still not well documented in the literature. (scirp.org)
  • One of the reasons is due to the absence of well-documented specific and sensitive validated chiral method for the determination of R- and S-acenocoumarol after oral administration of the drug in a well controlled clinical/pharmacokinetics study. (scirp.org)
  • Therefore, the main aim of our work was to develop and validate a highly specific and sensitive stereoselective liquid chromatographic-mass spectrometric method for the determination of R- and S-acenocoumarol in human plasma, as well, its application for the enantioselective pharmacokinetics evaluation of both enantiomers after oral dosing in human healthy subjects. (scirp.org)

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  • determination
  • A stereoselective, sensitive and rapid liquid chromatography-tandem mass spectrometry (LC- MSMS) method for the determination of R-acenocoumarol and S-acenocoumarol in human plasma was developed and validated at IPRC bioanalytical labs. (scirp.org)