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  • Musculoskeletal
  • Musculoskeletal abnormalities included hooked clavicles, 13 pairs of ribs, large hands and feet with long, slender fingers, widened metaphyses, and square-shaped vertebral bodies, which developed over time as a sign of muscular hypotonia. (mhmedical.com)
  • Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. (nih.gov)
  • ocular
  • described patients with Mental Motor Retardation, ocular abnormality, dysmorphic facial appearance, long fingers, and distal arthrogryposis with severely adducted thumbs and clubfeet in Turkish family in 1997. (wikipedia.org)
  • cells
  • Multiple myeloma is also known as plasma cell myeloma and is a cancer of plasma cells, a type of white blood cell. (newkerala.com)
  • Myelin is a substance made up of multiple types of cells, one of which is cholesterol. (walking-canes.net)
  • While many of the genetic and epigenetic abnormalities in neoplasms are probably neutral evolution, many have been shown to increase the proliferation of the mutant cells, or decrease their rate of death (apoptosis). (wikipedia.org)
  • family
  • In 2001 family with a distal limb and sternal abnormalities were reported by Dundar et al.This autosomal dominant disease signs which are syndactyly, preaxial polydactyly prominent and upper sternum were established in affected individuals. (wikipedia.org)
  • known
  • When only one mass is present, it is known as a plasmacytoma while more than one is known as multiple myeloma. (newkerala.com)
  • study
  • A recent study conducted by CORE Diagnostics reveal that genetic abnormalities are more prevalent among younger median age of 50 years to 70 years, which forms 65 per cent of total multiple myeloma cases. (newkerala.com)
  • Our study includes 1001 Indian patients, which would help in better understanding of genetic abnormalities among Indian population. (newkerala.com)
  • Musculoskeletal
  • Musculoskeletal abnormalities included hooked clavicles, 13 pairs of ribs, large hands and feet with long, slender fingers, widened metaphyses, and square-shaped vertebral bodies, which developed over time as a sign of muscular hypotonia. (mhmedical.com)
  • Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. (nih.gov)
  • Criteria
  • Alexander Friedenstein and his colleagues first identified osteoprogenitor cells in multiple mammalian tissues, before any genetic or morphological criteria were put in place for bone marrow or connective tissues. (wikipedia.org)
  • growth
  • The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) recommends that pregnant women have routine obstetric ultrasounds between 18 weeks and 22 weeks gestational age (the anatomy scan) in order to confirm pregnancy timing, to measure the fetus so that growth abnormalities can be recognized quickly later in pregnancy, and to assess for congenital malformations and multiple pregnancies (i.e. twins). (wikipedia.org)
  • cause
  • The formerly designated Borrelia burgdorferi has now been subdivided into multiple Borrelia species, including three that cause human infection. (asmscience.org)
  • It is common to have multiple strains at the same time, including those that can cause cervical cancer along with those that cause warts. (wikipedia.org)
  • Research
  • Research shows that routine obstetric ultrasound before 24 weeks gestational age can significantly reduce the risk of failing to recognize multiple gestations and can improve pregnancy dating to reduce the risk of labor induction for post-dates pregnancy. (wikipedia.org)
  • study
  • 2. Monsters, Mutants, and Master Genes Embryologists study how bodies develop, and the abnormalities when things go wrong, such as homeotic variants when one body part is changed into another (for instance, a fruit fly antenna becomes a leg with the Antennapedia mutant). (wikipedia.org)