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  • gene
  • Previously, the 5'-untranslated region (UTR) of the mouse MOR was found to be important for post-transcriptional regulation of the MOR gene in neuronal cells. (nih.gov)
  • To identify potential regulators of the mouse MOR gene, we performed affinity column chromatography using 5'-UTR-specific RNA oligonucleotides using neuroblastoma NS20Y cells. (nih.gov)
  • Translation of the mouse MOR gene is controlled by 5′UTR-deletion analysis. (nih.gov)
  • Potential regulatory 5UTRs were identified and filtered based on length, gene function, relative gene counts, and conservation in other organisms. (frontiersin.org)
  • UTR_ZMO0347 (5′UTR of gene ZMO0347 encoding the RNA binding protein Hfq) was found to down-regulate downstream gene expression under ethanol stress. (frontiersin.org)
  • The role of UTR_ZMO0347 and other 5UTRs gives us insight into the regulatory network of Z. mobilis in response to stress and unlocks new strategies for engineering robust industrial strains as well as for harvesting novel responsive regulatory biological parts for controllable gene expression platforms in this organism. (frontiersin.org)
  • The gene has 7 exons, spans 5 kilobases in length and in humans it is located on the long arm of chromosome 4 region 22 (4q1322.1). (wikipedia.org)
  • This structural transition can then expose or occlude important regions of RNA such as a ribosome binding site, which then affects the translation rate of a nearby protein-coding gene. (wikipedia.org)
  • RNA thermometers are found in the 5' UTR of messenger RNA, upstream of a protein-coding gene. (wikipedia.org)
  • This gene is a member of the regulators of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. (wikipedia.org)
  • Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene. (wikipedia.org)
  • The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. (wikipedia.org)
  • IRES
  • In the 5' UTR, the cloverleaf structure of domain (stem-loop) I is important for viral replication [2,while domains II to VI encompass the internal ribosome entry site (IRES) which directs translation of the mRNA by internal ribosome binding . (medcraveonline.com)
  • The 5' untranslated region contains an internal ribosomal entry site (Type I IRES). (wikipedia.org)
  • Upon entry of the genome into the cytoplasm of the host cell, the IRES in the 5' UTR recruits ribosomal subunits (cap-independent mechanism) which starts the translation process. (wikipedia.org)
  • upstream
  • The influence of an upstream open reading frame (ORF) in the 5′-untranslated region (UTR) of the mRNA on corticotropin-releasing hormone receptor type 1 (CRHR1) translation was studied in constructs containing the 5′-UTR of CRHR1, with or without an ATG-to-ATA mutation in the upstream ORF, and the main ORF of luciferase or CRHR1. (aspetjournals.org)
  • Upstream mutation in luciferase constructs increased luciferase activity when transfected into COS-7 or AtT20 cells compared with the native 5′-UTR. (aspetjournals.org)
  • The study shows that the upstream AUG in 5′-UTR of CRHR1 mRNA inhibits receptor expression by inhibiting mRNA translation and suggests the short open reading frame in the 5′-UTR plays a role in regulating translation of the CRH receptor. (aspetjournals.org)
  • Regions around 10 kb upstream and 1 kb downstream of Klf9 transcription start site contain conserved antioxidant response elements (AREs), which are binding sites for Nrf2. (wikipedia.org)
  • SQ1 and MVA increased reporter activity by ∼1.6- and 3-fold, respectively, from a construct beginning 49 base pairs (bp) upstream from the longest 5′-RACE product (-3140:-49). (aspetjournals.org)
  • bioinformatics
  • Considering the unique tolerance of Zymomonas mobilis to ethanol and the growing interest in engineering microbial strains with enhanced tolerance to industrial inhibitors, we searched natural cis -regulatory regions in this microorganism using transcriptomic data and bioinformatics analysis. (frontiersin.org)
  • proteins
  • the non-structural proteins are encoded in the P2 (2A, 2B and 2C) and P3 (3A, 3B, 3C and 3D polymerase) regions. (medcraveonline.com)
  • We confirmed the importance of TAR regions by subsequent site-specific mutagenesis and verified that the secretion deficiency of Peb1 mutants was not due to insolubility or aggregation of the proteins in the cytoplasm. (springer.com)
  • Most known RNA thermometers are located in the 5' untranslated region (UTR) of messenger RNA encoding heat shock proteins-though it has been suggested this fact may be due, in part, to sampling bias and inherent difficulties of detecting short, unconserved RNA sequences in genomic data. (wikipedia.org)
  • In addition to the Dbl homology and pleckstrin homology domains that are characteristic of the GEFs, Vav members consist of a calponin homology domain, an acidic region, a zinc finger region, and the structural hallmark of signal transduction proteins, the Src homology 2 (SH2) and SH3 domains. (jneurosci.org)
  • relatively
  • At low polyamine concentration the efficiency of translation in vitro of intact ODC mRNA is not relatively increased compared with that of an ODC mRNA having a truncated 5′ UTR or with that of control globin mRNA. (biochemj.org)
  • Since these noncanonical base pairs are relatively unstable, increased temperature causes local melting of the RNA structure in this region, exposing the Shine-Dalgarno sequence. (wikipedia.org)
  • secondary
  • From this we conclude that the well-documented negative feedback control of intracellular polyamines on ODC expression is not regulated by effects of polyamines on the secondary structure of the 5′ UTR of ODC mRNA. (biochemj.org)
  • sequences
  • In order to investigate the evolutionary diversity and molecular epidemiology in EV-C species, the 5' UTR and VP1 regions were analyzed in 16 clinical isolates from a single public-health laboratory (serving New South Wales, Australia), representing seven types (serotypes/genotypes) in EV-C. Sequences were compared with the 5' UTR and VP1 regions of 183 strains available in GenBank, representing the same seven types. (medcraveonline.com)
  • vivo
  • An in vivo fluorescence-based screening system was developed to confirm the responsiveness of 36 5′UTR candidates to ethanol, acetate, and xylose stresses. (frontiersin.org)
  • bind
  • The La/SSB autoantigen (La) was found to specifically bind to an N-5′UTR probe. (frontiersin.org)
  • found
  • Some RNA thermometers are significantly more complex than a single hairpin, as in the case of a region found in CspA mRNA which is thought to contain a pseudoknot, as well as multiple hairpins. (wikipedia.org)
  • The Hsp90 cis regulatory element is an RNA element (RNA thermometer) found in the 5' UTR of the Drosophila hsp90 mRNA. (wikipedia.org)
  • open readi
  • The short open reading frame (ORF) present in the 5′ UTR of rat ODC mRNA does not contribute to the observed inhibitory effect on translation efficiency in vitro . (biochemj.org)
  • Translation
  • Our data suggest that vimentin functions as a repressor of MOR translation, dependent on 175-150 of the MOR 5'-UTR. (nih.gov)
  • Our results show that the intact 5′ UTR of rat ODC mRNA, which is 303 nt in length, is a potent inhibitor of translation. (biochemj.org)
  • We report the presence of a homology in the 5'untranslated region UTR of the messenger RNA encoding C9orf72 with the iron responsive elements IRE that control expression of iron-associated transcripts and predict that this RNA structure may iron-dependently regulate C9orf72 translation. (duhnnae.com)
  • Recombinant La enhanced the translation of luciferase mRNA containing the N-5′UTR (N-fLuc), and RNA interference of La suppressed N-fLuc translation. (frontiersin.org)
  • These results suggest that La induced predominant translation of N mRNA via binding to its 5′UTR under shutoff conditions. (frontiersin.org)
  • presence
  • Such neutral processes could account for some of the observed patterns of intron presence [ 5 ], but do not rule out the possibility that adaptive processes are simultaneously contributing to the maintenance of some introns. (biomedcentral.com)
  • active
  • The remethylation pathway comprises 2 intersecting biochemical pathways and results in the transfer of a methyl group (CH 3 ) to homocysteine from methylcobalamin, which receives its methyl group from S-adenosylmethionine (SAM), from 5-methyltetrahydrofolate (an active form of folic acid), or from betaine (trimethylglycine). (medscape.com)
  • This pathway is dependent on adequate intake of vitamin B-6 and the hepatic conversion of vitamin B-6 into its active form, pyridoxal-5'-phosphate (P5P). (medscape.com)
  • product
  • It has been suggested that this conformational change occurs following phosphorylation, with the negatively charged Asp-62 moving away from the newly attached 5'-phosphate of the UMP/CMP product. (wikipedia.org)
  • mouse
  • A ) Schematic representation of the mouse MOR 5′-UTR. (nih.gov)