• fluorescence
  • It is found that looped-out 2-AP, an analogue of adenine, in split parallel G-quadruplexes, triplexes and duplexes always shows much higher fluorescence intensity than that in single- or double-stranded DNAs, due to the weaker quenching effects derived from the reduced base stacking environments. (rsc.org)
  • Taking advantage of these traits, we introduce a new strategy to monitor the behaviours of DNA nanodevices via the fluorescence signal output by utilizing changes in the base stacking environment of 2-AP. (rsc.org)
  • Compared with conventional fluorescence labelling, looped-out 2-AP as a reporter shows good photostability and can be quenched by base-pairing, thereby providing an efficient quencher-free methodology for monitoring DNA nanodevices. (rsc.org)
  • purine
  • 2-Aminopurine, a purine analog of guanine and adenine, is a fluorescent molecular marker used in nucleic acid research. (wikipedia.org)
  • A cyclopropane derivative of formula (I) ##STR1## wherein B1 is a purine or pyrimidine residue, R1 and R2 are, independently, hydrogen or a protecting group for hydroxyl and each of k, m and n represents, independently, an integer of 1 or 2 is useful for its antiviral effect. (google.com)
  • Antiviral Carbocyclic Purine nucleosides (-)Carbovir Abacavir Entecavir Carbocyclic 2′-ara-fluoro-guanosine Entecavir, a guanosine analog, was reported in 1997 as a potent and selective inhibitor for the hepatitis B virus, and approved by the FDA in March 2005 for oral treatment of hepatitis B infection. (wikipedia.org)
  • induce
  • Apolipoprotein E-deficient lipoproteins induce foam cell formation by activation of PERK-EIF-2 α signaling cascade," Journal of Bioanalysis and Biomedicine , vol. 2, no. 5, pp. 113-120, 2010. (hindawi.com)
  • 5-Bromouracil, systematic name 5-bromopyrimidine-2,4-dione, (abbreviated as 5-BrU, 5BrUra or br5Ura) is a brominated derivative of uracil that acts as an antimetabolite or base analog, substituting for thymine in DNA, and can induce DNA mutation in the same way as 2-aminopurine. (wikipedia.org)
  • analogue
  • The fluorocarbocyclic nucleoside carbocyclic 2′-ara-fluoro-guanosine was reported in 1988 as the first example of a carbocyclic analogue of an unnatural nucleoside to exhibit greater anti-herpes activity against the herpesviruses HSV-1 and HSV-2 in-vitro than its furanose parent. (wikipedia.org)
  • To overcome the fact that ribose's 2' hydroxy group that reacts with the phosphate linked 3' hydroxy group (RNA is too unstable to be used or synthesized reliably), a ribose analogue is used. (wikipedia.org)
  • base
  • Linear approaches to chiral carbocyclic nucleosides 2 rely on the construction of the heterocyclic base onto a suitable protected chiral cyclopentylamine (1 → 2). (wikipedia.org)
  • In the convergent approach the intact heterocyclic base is coupled directly to a suitably protected functionalised carbocyclic moiety (3 → 2). (wikipedia.org)
  • Herpes
  • Carbocyclic (E)-5-(2-bromovinyl)-2-deoxyuridine( (+) C-BVDU) GR95168 possesses activity against herpes simplex virus type l (HSV-1) and varicella zoster virus (VZV, chicken pox and shingles) in-vitro and in-vivo. (wikipedia.org)
  • potential
  • 2-Aminopurine inhibits lipid accumulation induced by apolipoprotein E-deficient lipoprotein in macrophages: potential role of eukaryotic initiation factor-2 α phosphorylation in foam cell formation," Journal of Pharmacology and Experimental Therapeutics , vol. 326, no. 2, pp. 395-405, 2008. (hindawi.com)
  • claim
  • 2. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier. (google.com)
  • 2. A cyclopropane according to claim 1 wherein each of k, m and n is 1. (google.com)
  • 2 . The method of claim 1 further comprising removing nucleotide derivatives and nucleotides that are not incorporated into the primer. (google.ca)
  • 3 . The method of claim 2 further comprising the step of repeating said conducting and removing steps using a second nucleotide species and a nucleotide derivative corresponding to a nucleotide species different from said second species. (google.ca)
  • 2. The method of claim 1 , wherein the first nucleotide sequence is longer than the non-mutant form of the repetitive nucleotide sequence. (google.com)
  • journal
  • J. Lewerenz and P. Maher, "Basal levels of eIF2 α phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression," Journal of Biological Chemistry , vol. 284, no. 2, pp. 1106-1115, 2009. (hindawi.com)
  • group
  • In particular, the invention relates to those 1H-1,2,3triazolo[4,5-d]pyrimidines which are substituted by an alkoxymethyl radical in position 1 and have an amino group in position 5 and are substituted by hydrogen, halogen, hydroxyl, alkoxy, amino, mercapto or alkylthio in position 7. (google.com)