- We demonstrate that the dispersal of as-prepared (AP), purified (PD), and carboxylated (COOH) MWCNTs by bovine serum albumin (BSA) and dipalmitoylphosphatidylcholine (DPPC) influences TGF-β1, PDGF-AA, and IL-1β production in vitro and in vivo. (cdc.gov)
- A unique surface interaction for perdeuterated ethanol and 1-butanol with dipalmitoylphosphatidylcholine (DPPC)/monosialoganglioside (G M1 ) multilamellar vesicles can be detected from the fast exchange averaging of the nuclear quadrupole coupling constant of the alcohol in the free and bound states using deuterium NMR. (elsevierpure.com)
- Raman spectra of aqueous dispersions of 1,2-dipalmitoyl-phosphatidylcholine (DPPC) have been measured as a function of pressure (up to 46 kbar) for samples incubated at 2°C and for nonincubated DPPC samples subjected to equally high pressure. (canada.ca)
- The intensity of the progression has been used to monitor the all-trans conformational state in phospholipid aqueous phases and in various regions of the 1,2-dipalmitoylphosphatidylcholine (DPPC)/cholesterol phase diagram. (researchwithrutgers.com)
- With the assumption that the intensity of the progression arises only from all-trans chains and is thus a highly nonlinear function of the number of gauche rotamers, the data suggest that about 1 gauche bond/chain exists in the "liquid-ordered" phase (33 mol % cholesterol) as compared with 3.6-4.2 gauche rotamers for the L α phase of DPPC alone. (researchwithrutgers.com)
- A quantitative comparison of 1,2-dipalmitoylphosphatidylcholine (DPPC) and 1,2-dipalmitoylphosphatidylethanolamine (DPPE) shows the former to have 0.4 double gauche (gg), 0.5 end gauche (eg), and about 1.0 (kink + gtg) conformers per chain just above the gel-liquid crystal phase transition, while the more highly ordered DPPE L α phase shows about 0.2 gg, 0.1 eg, and 1.0 (kink + gtg) conformers. (researchwithrutgers.com)
- Experiments on bilayers and monolayers containing lipids such as dipalmitoylphosphatidylcholine (DPPC) provide the essential target data for this project. (nih.gov)
- Phase-separation was observed in the form of domains made of dipalmitoylphosphatidylcholine (DPPC), sphingomyelin (SM), or SM/cholesterol (SM/Chl) surrounded by a fluid matrix of dioleoylphosphatidylcholine (DOPC). (ac.be)
- Time-lapse images collected following addition of 1 mM azithromycin revealed progressive erosion and disappearance of DPPC gel domains within 60 min. (ac.be)
- Dipalmitoylphosphatidylcholine (DPPC) is the main component of lung surfactants. (who.int)
- A Phospholipase A1 which is capable of hydrolyzing a phospholipid to produce a 2-acyl lysophospholipid and is obtainable from species of the fungus Aspergillus. (justia.com)
- The present invention relates to an enzyme capable of hydrolysing the 1-acyl group of a phospholipid, that is a Phospholipase A1, as well as to processes for the production and to the use of such an enzyme. (justia.com)
- Thus, a Phospholipase A1 hydrolyzes the 1-acyl group of a phospholipid, i.e. it hydrolyzes the bond between the fatty acid and the glycerine residue at the 1-position of the phospholipid. (justia.com)
- Selective hydrolysis of a phospholipid substrate with a Phospholipase A1 produces a 2-acyl lysophospholipid and selective hydrolysis of a phospholipid with a Phospholipase A2 results in the production of a 1-acyl lysophospholipid. (justia.com)
- We identified the 1-palmitoyl-2-linoleyl-phosphatidylcholine (PLPC) as one active phospholipid that inhibited the Th1 function of mature DCs whereas the dipalmitoyl-phosphatidylcholine had no significant effect. (bvsalud.org)
- A series of CH 2 wagging modes in the 1320-1370-cm -1 region of alkane and phospholipid IR spectra characteristic of nonplanar conformers has been used for quantitative evaluation of conformational states in disordered (phospholipid L α and H II and alkane liquid) phases. (researchwithrutgers.com)
- 2] Alsop, R. J., Maria, Schober R., and Rheinstadter, M. C. Swelling of Phospholipid Membranes by Divalent Metal Ions Depends on the Location of the Ions in the Bilayers. (sciendo.com)
- One aspect of the present invention provides a peptide-liposome complex composed of a lipid bilayer including (a) a first phospholipid, (b) a second phospholipid containing PEG, (c) cholesterol, and (d) a lipid conjugate consisting of the second phospholipid and a peptide having the amino acid sequence set forth in SEQ ID NO: 1. (justia.com)
- The second phospholipid may be 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)2000] (DSPE-mPEG2000) or 1,2-disteroyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000] (DSPE-PEG2000-MAL). (justia.com)
- Lucinactant contains the peptide sinapultide (KL4 acetate, KLLLLKLLLLKLLLLKLLLLK), dipalmitoylphosphatidylcholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (as the sodium salt), and palmitic acid. (wikipedia.org)
- At 1.0% perdeuterated ethanol or 0.5% perdeuterated 1-butanol, a small splitting of the alcohol resonance(s) was detected in the liquid-crystalline phase, but not in the gel phase of the bilayer. (elsevierpure.com)
- Fabrication and characterization of dipalmitoylphosphatidylcholine-attracting elastomeric material for joint replacements. (musc.edu)
- Among the four surfactant apoproteins identified, surfactant protein B (SP-B) and SP-C are two small hydrophobic proteins that make up 2-4% of the surfactant mass and are present in commercially available surfactant preparations. (medscape.com)
- Secondary outcomes included lung function (forced expiratory volume at one second (FEV 1 )), P aeruginosa density in sputum, and the Cystic Fibrosis Quality of Life Questionnaire-Revised (CFQ-R). (bmj.com)
- An L:S ratio greater than or equal to 2:1 indicates lung maturity. (pedsurglibrary.com)
- At 20 mol % cholesterol, a phase separation region is evident from 39 to 45°C. The conversion of the "liquid-ordered" to the "liquid-disordered" phase is accompanied by the formation of 0.15 double gauche conformers/chain, as monitored from localized CH 2 wagging vibrations. (researchwithrutgers.com)
- The shapes of the domains were found to change dramatically when a small amount (2 mol %) of cholesterol was incorporated in the monolayer. (mun.ca)
- The observed crystal packing of the domains provides a plausible model for the association of multiple tandemly linked EGF-like domains in proteins such as fibrillin-1, Notch, and protein S. This model is consistent with the known functional data and suggests a general biological role for these domains. (embl.de)
- This family consists of several caerin 1 proteins from Litoria species, Australian tree frogs. (bicnirrh.res.in)
- A Phospholipase A2 hydrolyzes the 2-acyl, or central acyl, group and Phospholipases C and D, which are also known as phosphodiesterases, cleave on the two sides of the phosphodiester linkage. (justia.com)
- Substantially more disorder is observed (∼2-2.5 gauche rotamers/chain at 50°C). The various IR measurements of acyl chain conformational order are compared. (researchwithrutgers.com)
- Thus, the species active on CD36 have been identified to have an sn-2 acyl group that incorporates a terminal g -hydroxy (or oxo)- a , b -unsaturated carbonyl (alcohol or aldehyde group). (gerli.com)
- The effect of MWCNTs surface charge was also investigated in terms of amino (−NH 2 ) and carboxyl (−COOH) surface modifications. (biomedcentral.com)
- [2] With amino acids , for example, in solution a chemical equilibrium will be established between the "parent" molecule and the zwitterion. (wikipedia.org)
- The ratio of reorientational relaxation time for Legendre polynomials of order 1 and 2 is approximately 2 for interface, intermediate, and bulk water, indicating the presence of jump dynamics in these water molecules. (iisc.ac.in)
- Well-dispersed AP- and PD-MWCNTs were readily taken up by BEAS-2B, THP-1 cells, and alveolar macrophages (AM) and induced more prominent TGF-β1 and IL-1β production in vitro and TGF-β1, IL-1β, and PDGF-AA production in vivo than nondispersed tubes. (cdc.gov)
- The compounds generated from different precursors are similar except for the chain length of the truncated oxidized fatty acid at the sn-2 position. (gerli.com)
- Later, other compounds were discovered that contain the same structural motif, a quaternary nitrogen atom with a carboxylate group attached to it via a -CH 2 - link. (wikipedia.org)
- In animal cells, the fatty acid from the 1-position is frequently 16:0 and that from the 2-position is 18:1 or 18:2, exceptionally more unsaturated fatty acids are found. (gerli.com)
- Stud Univ Babes-Bolyai, Biol 24(2):32-35. (cdc.gov)
- MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-glucosidic linkage at the reducing end of the maltooligosaccharide through an intramolecular transglucosylation reaction, while MTHase hydrolyzes the penultimate alpha-1,4 linkage of the reducing end, resulting in the release of trehalose. (unl.edu)
- 1993. In vitro percutaneous absorption and metabolism in man of 2-chloro-4-ethylamino-6-isopropylamine-s-triazine (atrazine). (cdc.gov)
- 1: Biochim Biophys Acta. (ac.be)
- A study of the L α → H II interconversion in two unsaturated phosphatidylethanolamines (1-palmitoyl-2-oleoyl- (POPE) and 1,2-dielaidoyl- (DEPE)) shows a substantial increase in both gg and eg conformers near temperatures leading to the inverted micellar state in each instance, with smaller percentage increases in (kink + gtg) states. (researchwithrutgers.com)
- The nanocomposites were fabricated with various weight percentages of carbon nanofibers (0.5%, 1%, 3%) that were treated with different silane coating thicknesses (2.8nm, 46nm) through melt-mixing and compressive processing. (asme.org)
- Based on their structure CNTs are classified as either, single-wall carbon nanotubes (SWCNTs), which comprise a single layer of carbon atoms, or multi-wall carbon nanotubes (MWCNTs), comprising of multiple concentric tubes [ 2 ]. (biomedcentral.com)
- Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes). (mdpi.com)
- This subfamily also includes bacterial alpha amylases and 1,4-alpha-glucan branching enzymes which are highly similar to MTHase. (unl.edu)
- Infection of iPSCs with lentiviral inserts is a highly efficient process since stem cells grow quickly, remain undifferentiated in specific cell culture conditions and can establish fully infected clones within 2-3 passages. (nature.com)
- Finally, a temperature dependence inconsistent with the prediction of the rotational isomeric state model is noted for the 1368-cm -1 band characteristic of (kink + gtg) conformers in alkanes. (researchwithrutgers.com)
- Here, we employ the phase-sensitive membrane dye di-4-ANEPPDHQ together with a variety of spectrally-resolved microscopy techniques, including 2-channel ratiometric TIRF microscopy and fluorescence lifetime imaging, to characterize membrane order at the T cell immunological synapse at high spatial and temporal resolution in live cells at physiological temperature. (ox.ac.uk)
- The phase changes were observed by incorporating 1 mol% of a fluorescent probe, NBD-PC, into the lipid forming the monolayer. (mun.ca)
- The SP-B gene is on human chromosome 2, and its primary translation product is 40 kd, which is clipped to become an 8-kd protein in the type II cells before entering lamellar bodies to be cosecreted with phospholipids. (medscape.com)
- Particularly, a considerable number of drugs with high therapeutic efficacy are currently used in clinical applications as monoclonal antibodies that selectively bind to immune checkpoints, specifically programmed death-ligand 1 (PD-L1), programmed death-receptor (PD-1), and cytotoxic T lymphocyte associated protein 4 (CTLA-4), which are involved in the interaction between cancer cells and T cells. (justia.com)
- In contrast, the gamma subunits in HgbF do not allow 2,3 DPG to bind easily and therefore HgF holds on to O 2 more tightly than HgbA. (pedsurglibrary.com)
- On the oxygen dissociation curve, HgbF represents a leftward shift compared to the normal curve because of its lack of affinity to bind 2,3-DPG and therefore a lower p50 compared to normal HgbA. (pedsurglibrary.com)
- The endpoints included clinical pathology, pharmacokinetics, and histopathology evaluation on Day 3 and Day 15 (2/sex/group/period). (hindawi.com)
- The Curvature Induction of Surface-Bound Antimicrobial Peptides Piscidin 1 and Piscidin 3 Varies with Lipid Chain Length," B. S. Perrin Jr., A. J. Sodt, M. L. Cotten and R. W. Pastor, Journal Of Membrane Biology , 248 (3, SI) pp. 455-467 (2015). (nih.gov)
- In the paralyzed state, the compliance of the chest wall is quite high and often greater than 25 mL/cm H 2 O. The ribs of the newborn infant are made mostly of cartilage and are quite elastic. (pedsurglibrary.com)
- These two sites are thought to differ functionally with site 1 acting as the initial starch recognition site and site 2 involved in the specific recognition of appropriate regions of starch. (unl.edu)
- it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-and beta-amylase limit-dextrins of amylopectin and glycogen. (unl.edu)
- In HgbA, 2,3 DPG binds to the beta subunits and facilitates the dissociation of oxygen from the HgbA molecule. (pedsurglibrary.com)
- The resultant images are captured on conventional high resolution photographic film [1] , digitized using a standard flatbed scanner, and then subjected to computer processing using a standard PC running MS Windows to yield a 3-dimensional image which can be further manipulated, based on available software and the investigators' objectives. (chronopause.com)
- The serial images obtained using TEM are aligned and stacked, at which point software is used to render a 3-dimensional representation of the imaged tissue ( Figure 2 and Figure 19 ). (chronopause.com)
- Unite de chimie des interfaces, Universite catholique de Louvain, Croix du Sud 2/18, B-1348 Louvain-la-Neuve, Belgium. (ac.be)