The zona fasciculata (sometimes, fascicular or fasciculate zone) constitutes the middle and also the widest zone of the adrenal ... The zona fasciculata also generates a small amount of weak androgens (e.g., dehydroepiandrosterone). The main source of ... Steroid-producing adrenal tumours and hyperplasia of the zona fasciculata result in excess cortisol production and are the ... Constituent cells are organized into bundles or "fascicles". The zona fasciculata chiefly produces glucocorticoids (mainly ...

It is produced in many animals, mainly by the zona fasciculata of the adrenal cortex in the adrenal gland. It is produced in ... Cortisol is produced in the human body by the adrenal gland in the zona fasciculata, the second of three layers comprising the ... Synthesis takes place in the zona fasciculata of the adrenal cortex. (The name cortisol is derived from cortex.) While the ... "Relation of intracellular K+ and steroidogenesis in isolated adrenal zona glomerulosa and fasciculata cells". Clinical Science ...

... zona fasciculata and zona reticularis. The main zone that expresses MC2 and MRAP is the zona fasciculata. Both proteins are ... The adrenal cortex is made of three zones: zona glomerulosa, ...

11β-hydroxylase is found in the zona fasciculata and zona glomerulosa. In general, corticosteroids are grouped into four ... Moreover, aldosterone synthase is found within the zona glomerulosa at the outer edge of the adrenal cortex; ...

... is primarily found in the zona fasciculata of the human adrenal cortex. Binding of the receptor by ACTH ... stimulates the production of glucocorticoids (GCs)-by contrast, aldosterone production from the zona glomerulosa is stimulated ...

The zona fasciculata has more 3β-hydroxysteroid dehydrogenase activity than the zona reticularis. Therefore, the zona ... It is divided into three separate zones: zona glomerulosa, zona fasciculata and zona reticularis. Each zone is responsible for ... The zona reticularis has more of the cofactors required for the 17,20-lyase activity of 17α-hydroxylase than zona fasciculata. ... It has been shown that the steroidogenic capacity of the zona fasciculata increases during illness in infants. The inner most ...

The corticosteroids are synthesized from cholesterol within the zona glomerulosa and zona fasciculata of adrenal cortex. Most ... 11β-hydroxylase is found in the zona glomerulosa and zona fasciculata. Aldosterone synthase is normally absent in other ... Hu C, Rusin CG, Tan Z, Guagliardo NA, Barrett PQ (June 2012). "Zona glomerulosa cells of the mouse adrenal cortex are intrinsic ... However, mouse zona glomerulosa cells within adrenal slices spontaneously generate membrane potential oscillations of low ...

Here, the zona fasciculata and zona reticularis, in response to ACTH, secrete glucocorticoids, in particular cortisol. In ...

These mutations tend to occur in young women with the adenoma in the cortisol secreting zona fasciculata. Adenomas without this ...

... especially in the zona fasciculata of the adrenal glands. ACTH acts by binding to cell surface ACTH receptors, which are ...

... s are chiefly produced in the zona fasciculata of the adrenal cortex, whereas mineralocorticoids are synthesized ... in the zona glomerulosa. Cortisol (or hydrocortisone) is the most important human glucocorticoid. It is essential for life, and ...

However, in humans, cortisol is the primary glucocorticoid that is produced primarily in the zona fasciculata of the adrenal ... Glomerulosa cells are found in the zona glomerulosa, which is the most superficial region of endocrine cells in the adrenal ...

In the human endocrine system, a spongiocyte is a cell in the zona fasciculata of the adrenal cortex containing lipid droplets ... The principal hormone secreted from the cells of the zona fasciculata are glucocorticoids, but some androgens are produced as ...

The zona fasciculata is situated between the zona glomerulosa and zona reticularis. Cells in this layer are responsible for ... The adrenal cortex itself is divided into three main zones: the zona glomerulosa, the zona fasciculata and the zona reticularis ... It is divided into three separate zones: zona glomerulosa, zona fasciculata and zona reticularis. Each zone is responsible for ... In the zona fasciculata, cells are arranged in columns radially oriented towards the medulla. Cells contain numerous lipid ...

The glucocorticoid family of hormones is synthesized in the middle layer of the adrenal cortex known as the zona fasciculata. ... Androgens, or sex hormones, are synthesized in the innermost layer of the adrenal cortex known as the zona reticularis. These ... Mineralocorticoid hormones are synthesized in the outermost layer of the adrenal cortex known as the zona glomerulosa. Their ...

Cortisol is secreted by the cortex of the adrenal gland from a region called the zona fasciculata in response to ACTH. Elevated ...

ACTH in turn binds to G protein-coupled receptors in the adrenal cortex, especially in the zona fasciculata of the adrenal ...

In adrenal cortex cells from zona fasciculata, the expression of the mRNAs encoding all three P450scc proteins is induced by ...

The product of this hybrid gene is aldosterone synthase that is ACTH-sensitive in the zona fasciculata of the adrenal gland. ... Aldosterone synthase is found within the zona glomerulosa at the outer edge of the adrenal cortex. Aldosterone synthase ...

ACTH is a peptide hormone that regulates the secretion of mainly glucocorticoids from the cells of the zona fasciculata of the ... ACTH can also regulate secretion of gonadocorticoids from the cells of the zona reticularis since they also express ACTH ...

... lying deep to the zona fasciculata and superficial to the adrenal medulla. The cells are arranged cords that project in ... The zona reticularis (sometimes, reticulate zone) is the innermost layer of the adrenal cortex, ... different directions giving a net-like appearance (L. reticulum - net). Cells in the zona reticularis produce precursor ...

... finding functional distinctions between the zona fasciculata and the zona glomerulosa of the adrenal cortex. She also conducted ...

... that signals the zona fasciculata and zona reticularis to produce their steroids. When the pituitary is unable to produce ACTH ... The zona glomerulosa is not controlled by ACTH, and remains able to produce a normal amount of mineralocorticoids. A dog with ...

... from zona fasciculata of adrenal gland. Thus, there is no mineralocorticoid overproduction. Also, there is no adrenal ...

... is a steroid hydroxylase found in the zona glomerulosa and zona fasciculata of the adrenal cortex. Named officially the ...

Most of the DOC is secreted by the zona fasciculata of the adrenal cortex which also secretes cortisol, and a small amount by ... the zona glomerulosa, which secretes aldosterone. DOC stimulates the collecting tubules (the tubules which branch together to ...

In humans, the adrenal cortex comprises three concentric zones including the zona glomerulosa, zona fasciculata, and zona ...

... in the zona fasciculata and mineralocorticoids (primarily, aldosterone) in the zona glomerulosa to regulate metabolism, blood ... In secondary and tertiary adrenal insufficiency, there is no effect on the production of aldosterone within the zona ... Adrenal insufficiency can also affect the zona reticularis and disrupt production of androgens, which are precursors to ... in which angiotensin II stimulates aldosterone production in the zona glomerulosa. Thus, dysfunction of the pituitary gland or ...

It is ubiquitously expressed in many tissues and cell types, including the zona reticularis and zona fasciculata (but not zona ... including the zona reticularis and zona fasciculata of the adrenal cortex, the Leydig cells of the testes, the thecal cells of ...

... the 21-hydroxylation in the zona fasciculata of the adrenal cortex is impaired, so 17α-hydroxyprogesterone and progesterone ...