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*  C21orf33
... with homology to an Escherichia coli and a zebrafish protein that maps to chromosome 21q22.3". Hum Genet. 99 (5): 616-23. doi: ... ES1 protein homolog, mitochondrial is a protein that in humans is encoded by the C21orf33 gene. GRCh38: Ensembl release 89: ... 1996). "Isolation of cDNA for a novel human protein KNP-I that is homologous to the E. coli SCRP-27A protein from the ... 1993). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 ( ...
*  Microphthalmia-associated transcription factor
... "nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate". Development. ... Protein kinase C-interacting protein 1 (PKC1) associates with MITF. Their association is reduced upon cell activation. When ... Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein ... Most transcription factors function in cooperation with other factors by protein-protein interactions. Association of MITF with ...
*  Guanylate cyclase
"Differential calcium signaling by cone specific guanylate cyclase-activing proteins from the zebrafish retina". PLoS ONE. 6 (8 ... In addition, studies have shown that zebrafish express a higher number of GCAPs than mammals, and that zebrafish GCAPs can bind ... Guanylate cyclase is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and ... Depending on cell type, it can drive adaptive/developmental changes requiring protein synthesis. In smooth muscle, cGMP is the ...
*  C6orf58
... is tied to liver development in an orthologous protein in zebrafish. The function of the human UPF0762 is not yet well ... DUF781 is the singular domain of the protein and spans 318 of the protein's 330 amino acids. DUF781 has been linked to liver ... "liver-enriched gene 1a and 1b encode novel secretory proteins essential for normal liver development in zebrafish". PLoS ONE. 6 ... "Analysis of vaccinia virus-host protein-protein interactions: validations of yeast two-hybrid screenings". J. Proteome Res. 8 ( ...
*  Neurogenomics
Tallafuss, Alexandra; Trepman, Alissa; Eisen, Judith S. (2009-12-01). "DeltaA mRNA and protein distribution in the zebrafish ... This can be a gene co-expression network, or a protein-protein interaction (PPI) network. The nodes of the network will be ... Several of these protein disrupting mutations have been able to be identified only with the aid of whole genome sequencing ... The zebrafish model system has already been used to study neuroregeneration and severe polygenic human diseases like cancer and ...
*  Magnesium transporter1 family
Morpholino knockdown of MagT1 and TUSC3 protein expression in zebrafish embryos resulted in early developmental arrest; excess ... They designated this protein, MagT1. MagT1 is of 335 amino acids and possesses five TMSs with an N-terminal cleavage site and a ... Knockdown of either MagT1 or TUSC3 protein lowered the total and free intracellular Mg2+concentrations in mammalian cell lines ... Goytain and Quamme identified a Mg2+ transporter encoded by an implantation-associated protein precursor, IAP, that is ...
*  Highwire (protein)
Wang H (February 2010). "Characterization of zebrafish Esrom (Myc-binding protein 2) RCC1-like domain splice variants". Mol ... Highwire (Hiw) is an E3 ubiquitin ligase protein associated with neuromuscular junction growth. It is frequently studied in ...
*  FXYD family
Two other family members that are not obvious orthologs of any identified mammalian FXYD protein exist in zebrafish. All these ... The FXYD protein family is a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning ... FXYD proteins appear to preferentially associate with Na,K-ATPase alpha1-beta isozymes, and affect their function in a way that ... FXYD proteins are widely distributed in mammalian tissues with prominent expression in tissues that perform fluid and solute ...
*  NWD1
It was originally identified during a search for immune system genes in zebrafish as a protein coding sequence related to APAF1 ... NWD1, short for NACHT and WD repeat domain containing 1, is a gene found in vertebrates, which encodes a protein that contains ... Correa RG, Krajewska M, Ware CF, Gerlic M, Reed JC (2014). "The NLR-related protein NWD1 is associated with prostate cancer and ... "Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish". Genome Biol. ...
*  Heat shock protein
"Small heat shock proteins are necessary for heart migration and laterality determination in zebrafish". Developmental Biology. ... Several heat shock proteins function as intra-cellular chaperones for other proteins. They play an important role in protein- ... The small 8-kilodalton protein ubiquitin, which marks proteins for degradation, also has features of a heat shock protein. A ... Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. ...
*  WNT8B
It encodes a protein showing 95%, 86%, and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, ... Protein Wnt-8b is a protein that in humans is encoded by the WNT8B gene. The WNT gene family consists of structurally related ... These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate ... Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". ...
*  Thalamus
"Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl". Development. 134 (1): 127-36. doi:10.1242/dev ... In zebrafish, it was shown that the expression of two SHH genes, SHH-a and SHH-b (formerly described as twhh) mark the MDO ... "Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon". Development. ...
*  Small Maf
Zebrafish) MAFG (Human), Mafg (Mouse), mafg (Zebrafish) MAFK (Human), Mafk (Mouse), mafk (Zebrafish) sMaf proteins were ... and Bach proteins (Bach1 and Bach2). Because these proteins cannot bind DNA by themselves, sMaf proteins are indispensable ... sMaf proteins form homodimers by themselves and heterodimers with two other bZIP families of transcription factors, namely CNC ... Because CNC and Bach proteins cannot bind to DNA by themselves, sMafs are indispensable partners of the CNC and Bach families ...
*  Phylotypic stage
In zebrafish, the interconnectivity of proteins over developmental time was found to be highest in early development, ... re-analyzed the zebrafish dataset published by Domazet-Lošo and Tautz. They found that applying a log-transformation to the ... In zebrafish, as well as in additional transcriptomic datasets of Drosophila, the mosquito Anopheles and the nematode ... Gene knockout experiments from mice and zebrafish demonstrated that the ratio of essential genes to non-essential genes ...
*  Proton-coupled folate transporter
... and zebrafish (AAH77859) proteins. Structurally, there are twelve transmembrane helices with the N- and C- termini directed to ... PCFT is located on chromosome 17q11.2 and consists of five exons encoding a protein with 459 amino acids and a MW of ~50kDa. ... "Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in ... "Molecular and biochemical characterization of folate transport proteins in retinal Müller cells". Investigative Ophthalmology ...
*  Germ line development
... the PGCs express two CXCR4 transmembrane receptor proteins. The signaling system involving this protein and its ligand, Sdf1, ... Regardless of PGC injection site, PGCs are able to correctly migrate to their target sites.[citation needed] In zebrafish, ... Bone morphogenetic protein 4 (BMP4) is released by the extra-embryonic ectoderm (ExE) at embryonic day 5.5 to 5.75 directly ... Pole plasm is organized by and contains the proteins and mRNA of the posterior group genes (such as oskar, nanos gene, Tudor, ...
*  SPNS2
The orthologous protein in zebrafish has been shown to transport sphingosine-1-phosphate (S1P) out of cells during vascular ... Spinster homolog 2 (Drosophila) is a protein that in humans is encoded by the SPNS2 gene. Model organisms have been used in the ... "The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors". Science. 323 (5913): 524-527. ...
*  Stereocilia (inner ear)
In this study, scientists used zebrafish to examine the motion of proteins within live ear cells using a confocal microscope. ... Fascin 2b, a protein involved in actin cross-linking, moves even faster. Constant movement of proteins within cells, along with ... This has shown that proteins in stereocilia move quickly, indicating that the movement of the proteins within the hair cells ... The fast movement of these proteins has changed our understanding of stereocilia and indicates that proteins within stereocilia ...
*  PLEKHA7
... a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish". Dis Model Mech. 4 ( ... The protein PDZD11 was identified as a protein interacting through its N-terminal region with the N-terminal WW domain of ... The protein was discovered in Masatoshi Takeichi's lab while looking for potential binding partners for the N-terminal region ... In the C-terminal half, the protein contains three coiled coil (CC) domains and two Proline-rich (Pro) domains. PLEKHA7 has ...
*  Hereditary sensory and autonomic neuropathy type I
The enzyme is implicated in the trafficking and signaling of type I bone morphogenetic protein (BMP) receptors in zebra fish ( ... The gene encodes SPTLC1 protein, which together with SPTLC2 protein, forms serine palmitoyltransferase (SPT) in humans. SPT is ... The gene encodes SPTLC2 protein which is one of two subunits of SPT. As mutations in the gene affect the same enzyme as those ... The protein also has de novo DNA methyltransferase activity which is responsible for establishing methylation patterns during ...
*  2012 in science
According to the study, a specialised protein prevents paralysing glial scars forming when zebrafish suffer spinal cord damage ... The protein helps prime stem cells to become specialized cells in mice. (Science Daily) (Cell Stem Cell) Analysts report that ... This process is described as "a step along the path toward amino acids and nucleotides, the raw materials of proteins and DNA, ... It is hoped that this protein may be exploited for the treatment of paralysed humans. (Sci-News) (J. Neurosci.) 4 June - A ...
*  AHCYL1
"Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo ... 2006). "IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/ ... receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor". J Biol Chem. 278 (12): 10602-12 ...
*  Dock180
"A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion ... Subsequently it was reported that Dock180 was able to activate the small GTP-binding protein (G protein) Rac1 and this was ... GEFs activate G proteins by promoting this nucleotide exchange. Dock180 and related proteins differ from other GEFs in that ... which contribute to cellular signalling events by activating small G proteins. In their resting state G proteins are bound to ...
*  Dock5
"A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion ... which function as activators of small G proteins. Dock5 is predicted to activate the small G protein Rac. Dock5 shares ... Meller N, Merlot S, Guda C (2005). "CZH proteins: a new family of Rho-GEFs". J. Cell Sci. 118 (Pt 21): 4937-46. doi:10.1242/jcs ... Côté JF, Vuori K (2007). "GEF what? Dock180 and related proteins help Rac to polarize cells in new ways". Trends Cell Biol. 17 ...
*  Midblastula
... and in zebrafish, the homeodomain protein Pou5f3 (a paralog of mammalian POU5F1 (OCT4) has an analogous role. Without the ... Zebrafish MBT occurs at cycle 10, whilst it occurs at cycle 13 in both Xenopus and Drosophila. Cells are thought to time the ... The exact method by which the cell achieves this control is unknown, but it is thought to involve a cytosolic protein. In ... Kane D, Kimmel C (1993). "The zebrafish midblastula transition". Development. 119 (2): 447-456. PMID 8287796. Mita I, Obata C ( ...
*  TENM3
The proteins were called Ten-ms in zebrafish, teneurins in chicken, Ten-m1-4, Odz1-4, Ten-m/Odz1-4, DOC4 in mouse, neurestin in ... Ten-m3 protein is expressed in the Purkinje's cell zone, molecular and granular layers and the white matter of the cerebellum. ... in 1999 from the original name, Ten-a, and the major site of the protein expression being in the nervous system. Like the Ten-m ... The 4 cysteine residues assist in protein folding, however, they are absent in Ten-m2 and Ten-m3. There are 41 amino acids in ...