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*  Free-radical theory of aging
This was supported by a study that showed superoxide production by xanthine oxidase and NO synthase in mesenteric arteries was ... 2009). "The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells". The Biochemical Journal. 423 (3 ... doi:10.1016/0047-6374(87)90057-1. Chung HY, Song SH, Kim HJ, Ikeno Y, Yu BP (1999). "Modulation of renal xanthine ...
*  Aldehyde oxidase 1
1993). "cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase". Proc ... "Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial ... Aldehyde oxidase 1 is an enzyme that in humans is encoded by the AOX1 gene. Aldehyde oxidase produces hydrogen peroxide and, ... 2007). "Human aldehyde oxidase 1 interacts with ATP-binding cassette transporter-1 and modulates its activity in hepatocytes". ...
*  Xanthine oxidase
... explaining why xanthine oxidase is being researched for links to cardiovascular health. Both xanthine oxidase and xanthine ... Because xanthine oxidase is a metabolic pathway for uric acid formation, the xanthine oxidase inhibitor allopurinol is used in ... xanthine + H2O2 xanthine + H2O + O2 ⇌ {\displaystyle \rightleftharpoons } uric acid + H2O2 Xanthine oxidase can also act on ... "Inhibitory effects of flavonoids on xanthine oxidase". Anticancer Research. 13 (6A): 2165-70. PMID 8297130. Xanthine Oxidase at ...
*  Xanthine oxidase inhibitor
A xanthine oxidase inhibitor is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine ... Xanthine oxidase inhibitors are being investigated for management of reperfusion injury. Xanthine oxidase inhibitors are of two ... inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are ... is only a weak inhibitor of xanthine oxidase. Pacher P, Nivorozhkin A, Szabó C (March 2006). "Therapeutic Effects of Xanthine ...
*  Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
The aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain is an evolutionary conserved protein domain. Aldehyde ... This activity is often found in a bifunctional enzyme with xanthine oxidase (EC 1.1.3.22) activity too. The enzyme can be ... Xanthine dehydrogenase (EC 1.1.1.204) catalyzes the hydrogenation of xanthine to urate, and also requires FAD, molybdenum and ... "Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas". Science. 270 (5239): 1170-6. doi: ...
*  Science and technology in Ukraine
See Xanthine oxidase. Volodymyr Vernadsky (1863-1945), mineralogist and geochemist, founder and first chairman of the Ukrainian ...
*  Theobromine poisoning
Xanthine oxidase Gennaro, M. C.; Abrigo, C. (1992). "Caffeine and theobromine in coffee, tea and cola-beverages or any other ... Theobromine poisoning, also wrongly called chocolate poisoning, is an overdosage reaction to the xanthine alkaloid theobromine ...
*  Bioisostere
Alloxanthine is an inhibitor of xanthine oxidase. It is also an isostere of xanthine, the normal substrate for the enzyme. ...
*  Neville Colman
Role of acetaldehyde/xanthine oxidase-generated superoxide". Biochemical Journal. 257 (1): 277-280. doi:10.1042/bj2570277. ISSN ...
*  Adenine deaminase
Blauch M, Koch FC, Hane ME (1939). "A study of xanthine oxidase of rat blood". J. Biol. Chem. 130: 471-486. Heppel LA, Hurwitz ...
*  Stelechocarpus burahol
F. & Th.] leaves extract and xanthine oxidase inhibitory study" (PDF). International Journal of Pharmacy and Pharmaceutical ...
*  Kidney disease
Xanthine oxidase will degrade hypoxanthine to xanthine and then to uric acid. Xanthine is not very soluble in water; therefore ... an increase in xanthine forms crystals (which can lead to kidney stones) and result in damage of the kidney. Xanthine oxidase ... Another possible cause of Kidney disease is due to decreased function of xanthine oxidase in the purine degradation pathway. ... xanthine oxidase deficiency, toxicity of chemotherapy agents, and long-term exposure to lead or its salts. Chronic conditions ...
*  Enzyme inhibitor
Pick, FM; McGartoll, MA; Bray, RC (1971). "Reaction of formaldehyde and of methanol with xanthine oxidase". European Journal of ...
*  Oxipurinol
By inhibiting xanthine oxidase, it reduces uric acid production. High serum uric acid levels may result in gout, kidney stones ... Oxipurinol (INN, or oxypurinol USAN) is an inhibitor of xanthine oxidase. It is an active metabolite of allopurinol and it is ...
*  Febuxostat
Xanthine oxidase is needed to successively oxidize both hypoxanthine and xanthine to uric acid. Hence, febuxostat inhibits ... It inhibits xanthine oxidase, thus reducing production of uric acid in the body. Febuxostat was discovered by scientists at the ... Febuxostat inhibits both oxidized as well as reduced form of xanthine oxidase because of which febuxostat cannot be easily ... Febuxostat is a non-purine-selective inhibitor of xanthine oxidase. It works by non-competitively blocking the molybdenum ...
*  Allopurinol
... inhibition of xanthine oxidase causes an increase in hypoxanthine and xanthine. While xanthine cannot be converted to purine ... and is an inhibitor of the enzyme xanthine oxidase. Xanthine oxidase is responsible for the successive oxidation of ... 1990). "Demonstration of a combined deficiency of xanthine oxidase and aldehyde oxidase in xanthinuric patients not forming ... xanthine oxidase, but this action is principally carried out by aldehyde oxidase. The active metabolite of allopurinol is ...
*  Molybdenum
... sulfite oxidase and xanthine oxidase. In some animals, and in humans, the oxidation of xanthine to uric acid, a process of ... is catalyzed by xanthine oxidase, a molybdenum-containing enzyme. The activity of xanthine oxidase is directly proportional to ... sulfite oxidase, xanthine oxidoreductase, aldehyde oxidase, and mitochondrial amidoxime reductase. People severely deficient in ... The Relationship between Sulfite Oxidase and the Acute Toxicity of Bisulfite and SO2". Proceedings of the National Academy of ...
*  Artificial cell
Palmour, RM; Goodyer, P; Reade, T; Chang, TM (16 September 1989). "Microencapsulated xanthine oxidase as experimental therapy ...
*  Thiouric acid
"Influence of xanthine oxidase on thiopurine metabolism in Crohn's disease". Alimentary Pharmacology & Therapeutics. 28 (6): 749 ...
*  Mercaptopurine
Allopurinol inhibits xanthine oxidase, the enzyme that breaks down mercaptopurine. Those taking allopurinol (often used to ...
*  Topiroxostat
... is a xanthine oxidase inhibitor which reduces serum urate levels. "New Drugs FY2013" (PDF). Pharmaceuticals and ...
*  Xanthinuria
... , also known as xanthine oxidase deficiency, is a rare genetic disorder causing the accumulation of xanthine. It is ... Type II xanthinuria and molybdenum cofactor deficiency lack one or two other enzyme activities in addition to xanthine oxidase ... caused by a deficiency of the enzyme xanthine oxidase. It was first formally characterized in 1954. Type I xanthinuria can be ... Sufferers have unusually high concentrations of xanthine in their blood and urine, which can lead to health problems such as ...
*  Pholiota squarrosa
The compounds, named squarrosidine and pinillidine, inhibit the enzyme xanthine oxidase. Xanthine oxidase catalyzes the ...
*  Tioguanine
This metabolic pathway is not dependent on the efficacy of xanthine oxidase, so that the inhibitor of xanthine oxidase, the ... This pathway also is independent of the enzyme activity of xanthine oxidase. 6-Thioguanine is a thio analogue of the naturally ... then by oxidation by xanthine oxidase of the thioxanthine to thiouric acid. ...
*  Sabyasachi Sarkar
"Modelling the reduced xanthine oxidase in active sulfo and inactive desulfo forms". Dalton Transactions. 42 (9): 3050. doi: ... A Replica of a Fishy Enzyme and the reduced xanthine oxidase also have been made.Inhibition patterns in the Michaelis complex ... "Modeling for the Active Site of Sulfite Oxidase: Synthesis, Characterization, and Reactivity of [MoVIO2(mnt)2]2- (mnt2- = 1,2- ... "Inhibition patterns of a model complex mimicking the reductive half-reaction of sulphite oxidase". Biochemical Journal. 319 (Pt ...
*  Molybdopterin
Enzymes that contain the molybdopterin cofactor include xanthine oxidase, DMSO reductase, sulfite oxidase, and nitrate ... Molydopterin is a: Cofactor of: xanthine oxidase, DMSO reductase, sulfite oxidase, nitrate reductase, ethylbenzene ... In some enzymes, such as xanthine oxidase, the metal is bound to one molybdopterin, whereas, in other enzymes, e.g., DMSO ... Although a tungsten-containing xanthine dehydrogenase from bacteria has been found to contain tungsten-molydopterin and also ...
*  Aldehyde dehydrogenase (FAD-independent)
"Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas". Science. 270 (5239): 1170-6. doi: ... Fujishiro K, Aisaka K, Uwajima T (2003). "Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690 ... Other names in common use include aldehyde oxidase, aldehyde oxidoreductase, Mop, and AORDd. As of late 2007, only one ...