... with anti-Wnt1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor LEF/TCF and diminished the ... the SFRP1 netrin-related motif is also found in a range of other proteins that is thought to mediate protein-protein ... Secreted frizzled-related protein 1, also known as SFRP1, is a protein which in humans is encoded by the SFRP1 gene. Secreted ... SFRP1 are heparin-binding proteins, with the heparin-binding domain within the C-terminal region of the SFRP1 protein. In vitro ...
... and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein ... Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the TAB1 gene ... This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents ... "Entrez Gene: MAP3K7IP1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1". "TAB1 (human)". www.phosphosite ...
... wnt proteins MeSH D12.644.276.996.500 - wnt1 protein MeSH D12.644.276.996.750 - wnt2 protein MeSH D12.644.360.011 - activating ... 14-3-3 proteins MeSH D12.644.360.024.318 - proto-oncogene proteins c-crk MeSH D12.644.360.024.326 - proto-oncogene proteins c- ... ral gtp-binding proteins MeSH D12.644.360.525.462 - ran gtp-binding protein MeSH D12.644.360.525.475 - rap gtp-binding proteins ... grb2 adaptor protein MeSH D12.644.360.024.298 - grb7 adaptor protein MeSH D12.644.360.024.300 - grb10 adaptor protein MeSH ...
In molecular biology, the protein domain, WIF N-terminal refers to the N terminal domain of the protein, WIF. It stands for, ... Members of the Wnt gene family are defined by their sequence similarity to mouse Wnt-1 and Wingless in Drosophila. They encode ... The Wnt proteins seem to adhere to the plasma membrane of the secreting cells and are therefore likely to signal over only few ... Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. ...
The structure of the gene and protein are well understood in research, PAX3 consists of 10 exons and results in major proteins ... PAX3 controls the neural crest development through regulation of c-RET, TGF-b2, and WNT1 which are essential controllers of ... resulting in essential proteins. These proteins are responsible for multiple functions in early human development such as stem ...
... wnt proteins MeSH D23.348.479.996.500 - wnt1 protein MeSH D23.348.479.996.750 - wnt2 protein MeSH D23.348.505.501 - interleukin ... hiv core protein p24 MeSH D23.050.327.520.330 - hiv envelope protein gp41 MeSH D23.050.327.520.350 - hiv envelope protein gp120 ... adenovirus e1 proteins MeSH D23.050.327.045.060 - adenovirus e2 proteins MeSH D23.050.327.045.070 - adenovirus e3 proteins MeSH ... ldl-receptor related protein 2 MeSH D23.050.422.500.750 - ldl-receptor related protein-associated protein MeSH D23.050.550.325 ...
Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene. This gene encodes a member of the ... 2000). "SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm". Development ... "Entrez Gene: SFRP2 secreted frizzled-related protein 2". Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, ... 2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and ...
Also, the authors witnessed a toxicity to the Cre protein that is not seen with the Flp protein. The efficacy of the FLPe ... The authors created a two transgenic mouse lines: a neuronal Wnt1::Flp fusion line and a line that possessed the FRT cassette ... The Flp protein, much like Cre, is a tyrosine family site-specific recombinase. This family of recombinases performs its ... The FLP protein was thermolabile (denatured at elevated temperatures) and therefore was not useful in the mammalian model due ...
Paired box gene 2, also known as Pax-2, is a protein which in humans is encoded by the PAX2 gene. The Pax Genes, or Paired-Box ... GeneCard for WNT1 Nolte J (2009). The human brain: an introduction to its functional anatomy (6th ed.). Philadelphia, PA: Mosby ... GeneReviews/NCBI/NIH/UW entry on Renal Coloboma Syndrome PAX2+protein,+human at the U.S. National Library of Medicine Medical ... Lechner MS, Levitan I, Dressler GR (Jul 2000). "PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is ...
DIX domains are unique: the only other proteins known to have a DIX domain are Dishevelled and DIXDC1. (The single Dsh protein ... Wnt-1 and MMTV-c-Neu transgenic carcinomas". The Journal of Biological Chemistry. 277 (25): 22692-22698. doi:10.1074/jbc. ... In Drosophila, the homologous protein is called armadillo. β-catenin is a subunit of the cadherin protein complex and acts as ... The first helices of the ARM domain form an additional, special protein-protein interaction pocket: This can accommodate a ...
The LBH or Limb-Bud and Heart protein is 105 aa long nuclear protein and is highly conserved across vertebrate species. LBH is ... Studies examining the role of Lbh in tumorigenesis in MMTV-Wnt1 transgenic mice as a model for Wnt induced breast cancer ... The LBH (Limb Bud-Heart) gene is a highly conserved human gene that produces the LBH protein, a transcription co-factor in the ... It contains three exons that will be translated to create the final protein product. Currently, there is no identified promoter ...
This molecule belongs to a protein superfamily exhibiting conserved motifs of the thrombospondin type 1 repeat. Proteins of ... March 2011). "Hydrocephalus and abnormal subcommissural organ in mice lacking presenilin-1 in Wnt1 cell lineages". Brain ... One of the proteins secreted by the subcommissural organ, and which is present in Reissner's fiber, is spondin. SCO-spondin is ... The ependymal cells of the SCO are also involved in the production of brain transthyretin, a protein involved in the transport ...
... identification of protein-protein interactions and characterization of a core protein". Journal of Molecular Biology. 285 (1): ... Wang R, Zheng J, Zhang DS, Yang YH, Zhao ZF (2015). "Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation". ... proteins [p45 NF-E2 (NFE2), Nrf1 (NFE2L1), Nrf2 (NFE2L2), and Nrf3 (NFE2L3)] and Bach proteins (BACH1 and BACH2). sMaf ... MAFK+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) FactorBook MafK (Articles with ...
RNA-binding protein FUS MeSH D12.776.624.664.700.957 - stathmin MeSH D12.776.624.664.700.967 - wnt1 protein MeSH D12.776. ... groel protein MeSH D12.776.602.500.500.100 - fusion proteins, bcr-abl MeSH D12.776.602.500.500.320 - fusion proteins, gag-onc ... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... fusion proteins, gag-pol MeSH D12.776.964.775.350.400 - hiv core protein p24 MeSH D12.776.964.775.375.325 - fusion proteins, ...
Portal: Biology v t e (G proteins, Genes mutated in mice, All stub articles, Protein stubs). ... Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ (2001). "Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1 ... RhoU (or Wrch1 or Chp2) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rho ...
Lee MO, Kang HJ, Cho H, Shin EC, Park JH, Kim SJ (November 2001). "Hepatitis B virus X protein induced expression of the Nur77 ... "Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation ... In addition, subcellular localization of the NR4A1 protein appears to play a key role in the survival and death of cells. ... Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple alternatively spliced variants, ...
"Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... Wnt-1 and MMTV-c-Neu transgenic carcinomas". The Journal of Biological Chemistry. 277 (25): 22692-8. doi:10.1074/jbc.M201975200 ... Oneyama C, Nakano H, Sharma SV (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction ... "Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living ...
This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following ... "Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation ... known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein ... a missing link between the unfolded protein response pathway and ER-associated protein degradation?". Current Protein & Peptide ...
Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ... Wnt-1 and MMTV-c-Neu transgenic carcinomas". The Journal of Biological Chemistry. 277 (25): 22692-22698. doi:10.1074/jbc. ... HER2 proteins have been shown to form clusters in cell membranes that may play a role in tumorigenesis. Evidence has also ... The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of ...
For example, Wnt-1 was found to have no role in the closing of the neural plate, despite being present at the tip of the neural ... "Isolation of cDNAs partially encoding four XenopusWnt-1int-1-related proteins and characterization of their transient ... Though mutants of Wnt-1 does lead to pattern defects within the brain. Notch1 is involved with formation of somites. HNF-3 is ...
"MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic ... also called vacuole membrane protein). Despite being located in intronic regions of a coding gene in the direction of ...
The primary function of Image Studio Lite is to quantitate relative abundance of proteins on a Western blot or DNA/RNA in an ... Chen, Y.; Chen, L.; Yin, Q.; Gao, H.; Dong, P.; Zhang, X.; Kang, J. (2013). "Reciprocal Interferences of TNF-α and Wnt1/β- ...