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*  Wnt signaling pathway
When Wnt1 was discovered, it was first identified as a proto-oncogene in a mouse model for breast cancer. The fact that Wnt1 is ... Dsh proteins are present in all organisms and they all share the following highly conserved protein domains: an amino-terminal ... For example, Wnt proteins are palmitoylated. The protein porcupine mediates this process, which means that it helps regulate ... "Pharmacological interventions in the Wnt pathway: inhibition of Wnt secretion versus disrupting the protein-protein interfaces ...
*  WNT1
Proto-oncogene protein Wnt-1 is a protein that in humans is encoded by the WNT1 gene. The WNT gene family consists of ... identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in ... "Entrez Gene: WNT1 wingless-type MMTV integration site family, member 1". McMahon AP, Moon RT (1990). "int-1--a proto-oncogene ... 2002). "Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer ...
*  WNT1-inducible-signaling pathway protein 3
... (WISP3, also named CCN6) is a matricellular protein that in humans is encoded by the ... These proteins, together with WISP1 (CCN4), and WISP2 (CCN5) comprise the six-member CCN family in vertebrates. CCN proteins ... Chen CC, Lau LF (April 2009). "Functions and mechanisms of action of CCN matricellular proteins". Int. J. Biochem. Cell Biol. ... It is a member of the CCN family (CCN intercellular signaling protein) of secreted, extracellular matrix (ECM)-associated ...
*  WNT1-inducible-signaling pathway protein 1
... (WISP-1), also known as CCN4, is a matricellular protein that in humans is encoded ... CCN intercellular signaling protein). The CCN family of proteins shares a common molecular protein structure, characterized by ... "Entrez Gene: WISP1 WNT1 inducible signaling pathway protein 1". Chen CC, Lau LF (Apr 2009). "Functions and mechanisms of action ... "WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary ...
*  WNT1-inducible-signaling pathway protein 2
... , or WISP-2 (also named CCN5) is a matricellular protein that in humans is encoded by ... These proteins, together with WISP1/CCN4, WISP2 (CCN5, this gene), and WISP3 (CCN6) comprise the six-member CCN family in ... CCN proteins characteristically contain an N-terminal secretory signal peptide followed by four structurally distinct domains ... However, WISP-2 is unique among this family of proteins by lacking precisely the CT domain. WISP-2 (CCN5) inhibits the ...
*  Mesoderm
The neural tube activates the protein WNT1 that expresses PAX 2 so the somite creates the myotome and dermatome. Finally, the ... The notochord and the neural tube activate the protein SHH which helps the somite to form its sclerotome. The cells of the ... epidermis and lateral plate mesoderm send signals for somite differentiation Notochord protein accumulates in presomitic ... sclerotome express the protein PAX1 that induces the cartilage and bone formation. ...
*  List of MeSH codes (D12.644)
... wnt proteins MeSH D12.644.276.996.500 --- wnt1 protein MeSH D12.644.276.996.750 --- wnt2 protein MeSH D12.644.360.011 --- ... rap gtp-binding proteins MeSH D12.644.360.525.475.100 --- rap1 gtp-binding proteins MeSH D12.644.360.525.500 --- ras proteins ... grb2 adaptor protein MeSH D12.644.360.024.298 --- grb7 adaptor protein MeSH D12.644.360.024.300 --- grb10 adaptor protein MeSH ... 14-3-3 proteins MeSH D12.644.360.024.318 --- proto-oncogene proteins c-crk MeSH D12.644.360.024.326 --- proto-oncogene proteins ...
*  Neurogenic locus notch homolog protein 4
Uyttendaele H, Soriano JV, Montesano R, Kitajewski J (1998). "Notch4 and Wnt-1 proteins function to regulate branching ... The notch protein is cleaved in the trans-Golgi network, and then presented on the cell surface as a heterodimer. The protein ... The neurogenic locus notch homolog 4 protein is a member of the Notch family. Members of this type 1 transmembrane protein ... Notch protein family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch ...
*  SLC6A20
2004). "Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation". J. Biol. Chem. 279 (43): 44582-9. ... The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl ... Solute carrier family 6, member 20 also known as SLC6A20 is a protein which in humans is encoded by the SLC6A20 gene. Transport ... of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been ...
*  NLK
2004). "Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK". Genes Dev. 18 (7): 816 ... 2004). "Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation". J. Biol. Chem. 279 (43): 44582-9. ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... Serine/threonine protein kinase NLK is an enzyme that in humans is encoded by the NLK gene. Its name is an abbreviation for ...
*  List of MeSH codes (D23)
... wnt proteins MeSH D23.348.479.996.500 --- wnt1 protein MeSH D23.348.479.996.750 --- wnt2 protein MeSH D23.348.505.501 --- ... hiv core protein p24 MeSH D23.050.327.520.330 --- hiv envelope protein gp41 MeSH D23.050.327.520.350 --- hiv envelope protein ... adenovirus e1 proteins MeSH D23.050.327.045.060 --- adenovirus e2 proteins MeSH D23.050.327.045.070 --- adenovirus e3 proteins ... ldl-receptor related protein 2 MeSH D23.050.422.500.750 --- ldl-receptor related protein-associated protein MeSH D23.050. ...
*  Metencephalon
Wnt1 is a proto-oncogene protein (Wingless-type MMTV integration site family, member 1). This gene was originally thought to ... Wnt1 is thought to be behind the genetic disorder called Joubert Syndrome, a disorder that affects the cerebellum. Otx1 and ... Fgf8 is also known as Fibroblast Growth Factor 8. It is a protein that is widely thought to be the most important organizing ... Two of the major genes that affect the metencephalon are Fgf8 and Wnt1, which are both expressed around the isthmus. ...
*  List of MeSH codes (D12.776)
RNA-binding protein FUS MeSH D12.776.624.664.700.957 - stathmin MeSH D12.776.624.664.700.967 - wnt1 protein MeSH D12.776. ... groel protein MeSH D12.776.602.500.500.100 - fusion proteins, bcr-abl MeSH D12.776.602.500.500.320 - fusion proteins, gag-onc ... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... fusion proteins, gag-pol MeSH D12.776.964.775.350.400 - hiv core protein p24 MeSH D12.776.964.775.375.325 - fusion proteins, ...
*  Reptin
This complex enhances transcription of specific genes, including Wnt1 and the metastasis-associated protein KAI1, and thereby ... This event occurs in the NuA4 protein complex. One more function of reptin is its interaction with heat shock protein 90 (HSP90 ... and regions for binding to other reptin proteins to form a hexamer ring as well as pontin and other proteins. The reptin ... where it assists regulation of polycomb group proteins (PcG). In turn, PcG proteins regulate chromatin structure to turn Hox ...
*  Von Willebrand factor type C domain
WNT1-inducible-signaling pathway protein 1 (WISP1) CCN5: WNT1-inducible-signaling pathway protein 2 (WISP2) Colombatti A, ... Von Willebrand factor, type C (VWFC or VWC)is a protein domain is found in various blood plasma proteins: complement factors B ... BMP binding endothelial regulator (BMPER) Cysteine-rich motor neuron 1 protein (CRIM1) Extracellular matrix protein 2 (ECM2) ... type C repeat which is found in multidomain protein/multifunctional proteins involved in maintaining homeostasis. For the von ...
*  MTA1
... and Wnt1 and rhodopsin due to release of their transcriptional inhibition by homeodomain protein Six3, MTA1 interacts with ERĪ± ... Metastasis-associated protein MTA1 is a protein that in humans is encoded by the MTA1 gene. MTA1 is the founding member of the ... Kleene R, Zdzieblo J, Wege K, Kern HF (Aug 1999). "A novel zymogen granule protein (ZG29p) and the nuclear protein MTA1p are ... "Metastasis-associated protein 1 and its short form variant stimulates Wnt1 transcription through promoting its derepression ...
*  Myogenesis
Class A proteins are the most abundant and are synthesized continuously throughout myogenesis. Class B proteins are proteins ... Meanwhile, Myf5 expression is regulated by Sonic hedgehog, Wnt1, and MyoD itself. By noting the role of MyoD in regulating Myf5 ... this means that the protein made binds the myoD gene and continues a cycle of MyoD protein production. ... Class C proteins are those synthesized at specific times during development. Also 3 different forms of actin were identified ...
*  WNT10B
... identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the ... Protein Wnt-10b (formerly Wnt12) is a protein that in humans is encoded by the WNT10B gene. The WNT gene family consists of ... These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate ... It may be involved in breast cancer, and its protein signaling is, it is presumed, a molecular switch that governs adipogenesis ...
*  CCN protein
WNT1 inducible signaling pathway protein-1) CCN5: WISP2 (WNT1 inducible signaling pathway protein-2) CCN6: WISP3 (WNT1 ... The CCN protein family includes the following six proteins: CCN1: CYR61 (cysteine-rich angiogenic protein 61) CCN2: CTGF ( ... Together with three Wnt-induced secreted proteins, they comprise the CCN family of matricellular proteins. These proteins have ... CCN proteins are a family of extracellular matrix (ECM)-associated proteins involved in intercellular signaling. Due to their ...
*  Secreted frizzled-related protein 1
... with anti-Wnt1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor LEF/TCF and diminished the ... the SFRP1 netrin-related motif is also found in a range of other proteins that is thought to mediate protein-protein ... Secreted frizzled-related protein 1, also known as SFRP1, is a protein which in humans is encoded by the SFRP1 gene. Secreted ... SFRP1 are heparin-binding proteins, with the heparin-binding domain within the C-terminal region of the SFRP1 protein. In vitro ...
*  MAP3K7IP1
... and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein ... Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the MAP3K7IP1 ... This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents ... "Entrez Gene: MAP3K7IP1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1". Omori E, Matsumoto K, Sanjo H, ...
*  Progesterone
92-. ISBN 978-0-323-29296-2. Faivre, E. J.; Lange, C. A. (30 October 2006). "Progesterone Receptors Upregulate Wnt-1 To Induce ... Progesterone binds extensively to plasma proteins, including albumin (50-54%) and transcortin (43-48%). It has similar affinity ... "Characterization of high affinity progesterone-binding membrane proteins by anti-peptide antiserum". Steroids. 63 (2): 111-6. ... Epidermal Growth Factor Receptor Transactivation and c-Src-Dependent Sustained Activation of Erk1/2 Mitogen-Activated Protein ...
*  PAX6
Paired box protein Pax-6, also known as aniridia type II protein (AN2) or oculorhombin, is a protein that in humans is encoded ... Pax6 is controlled by the signaling molecules Wnt1 and FGF8 and regulates eye, brain, and pancreas development. This gene is ... The encoded protein contains two different binding sites that are known to bind DNA and function as regulators of gene ... PAX6 protein at the US National Library of Medicine Medical Subject Headings (MeSH) GeneReviews/NCBI/NIH/UW entry on ...
*  WIF domain
In molecular biology, the protein domain, WIF N-terminal refers to the N terminal domain of the protein, WIF. It stands for, ... Members of the Wnt gene family are defined by their sequence similarity to mouse Wnt-1 and Wingless in Drosophila. They encode ... The Wnt proteins seem to adhere to the plasma membrane of the secreting cells and are therefore likely to signal over only few ... Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. ...
*  SIX3
Homeobox protein SIX3 is a protein that in humans is encoded by the SIX3 gene. The SIX homeobox 3 (SIX3) gene is crucial in ... By blocking Wnt1 activity, SIX3 is able to prevent abnormal expansion of the posterior portion of the brain into the anterior ... "The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in ... "The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in ...
*  Wrch1
Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ (2001). "Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1 ... RhoU (or Wrch1 or Chp2) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rho ...