*  Somnolence
Such somnolence is one of several sickness behaviors or reactions to infection that some theorize evolved to promote recovery ... the maintenance of wakefulness test and the epworth sleepiness scale: failure of the MSLT as a gold standard". Journal of Sleep ... other agents impacting the central nervous system in sufficient or toxic doses A number of diagnostic tests, including the ... bacterial or other agents) encephalopathy - (hepatic, uremic or other causes) epilepsy - after seizure fibromyalgia ...
*  List of designer drugs
Eugeroics (armodafinil and modafinil) - wakefulness promoting agents; modafinil increases alertness, particularly in sleep ... psychoactive effects that promote alertness, attention, and task switching; these effects are most pronounced during the first ... wakefulness, endurance, productivity, and motivation, increased arousal, locomotion, heart rate, and blood pressure, and the ...
*  Nootropic
Eugeroics (armodafinil and modafinil) - wakefulness promoting agents; modafinil increases alertness, particularly in sleep ... psychoactive effects that promote alertness, attention, and task switching; these effects are most pronounced during the first ...
*  Caffeine
Wakefulness-promoting agent Nootropic Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 15: Reinforcement and Addictive ... Knockout mouse studies have specifically implicated antagonism of the A2A receptor as responsible for the wakefulness-promoting ... Disinhibition of the tuberomammillary nucleus is the chief mechanism by which caffeine produces wakefulness-promoting effects. ... At normal doses, caffeine has variable effects on learning and memory, but it generally improves reaction time, wakefulness, ...
*  Modafinil sulfone
... (code name CRL-41056) is an achiral, oxidized metabolite of modafinil, a wakefulness-promoting agent. It is ... does not appear to contribute to the wakefulness-promoting/psychostimulant effects of modafinil. However, like modafinil, ... Chatterjie N, Stables JP, Wang H, Alexander GJ (2004). "Anti-narcoleptic agent modafinil and its sulfone: a novel facile ...
*  Stimulant
It may be used as a nasal/sinus decongestant, as a stimulant, or as a wakefulness-promoting agent. The salts pseudoephedrine ... Tashkin, D. P. (1 March 2001). "Airway effects of marijuana, cocaine, and other inhaled illicit agents". Current Opinion in ... Glennon RA (2013). "Phenylisopropylamine stimulants: amphetamine-related agents". In Lemke TL, Williams DA, Roche VF, Zito W. ... Common effects may include increased alertness, awareness, wakefulness, endurance, productivity, and motivation, arousal, ...
*  Atypical depression
The wakefulness-promoting agent modafinil has shown considerable effect in combating atypical depression, maintaining this ...
*  Armodafinil
"Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent ... Armodafinil has wake-promoting actions similar to sympathomimetic agents including amphetamine and methylphenidate, although ... However, the wake-promoting effects of modafinil, unlike those of amphetamine, were not antagonized by the dopamine receptor ... Phillips, J. B.; Simmons, R. G.; Arnold, R. D. (2011). "A single dose of armodafinil significantly promotes vigilance 11 hours ...
*  No-go pill
A go pill refers to a wakefulness-promoting agent used for fatigue management, especially in a military combat-readiness ... Modafinil, a wakefulness-promoting drug (or eugeroic) Air Force Special Operations Command Instruction 48-101 Archived June 11 ... context; this is contrasted with a no-go pill, which is used to promote sleep in support of combat operations. A go pill ...
*  Dopamine reuptake inhibitor
... whereas releasing agents induce de-polarization of the neuron membrane. The wakefulness-promoting agent modafinil and its ... These act as weak (micromolar) DRIs, but this effect does not correlate with wakefulness-promoting effects, suggesting the ... The conclusion is these drugs promote wakefulness via some other mechanism.[disputed - discuss] DRIs have been explored as ... and potentially more potently as dopamine releasing agents (DRAs) (due to Yerkes-Dodson's law, 'more potently stimulated' may ...
*  Eugeroic
... also known as wakefulness-promoting agents and wakefulness-promoting drugs, are a class of drugs that promote wakefulness and ... A Novel Vigilance Promoting Agent". CNS Drug Reviews. 5 (3): 193-212. doi:10.1111/j.1527-3458.1999.tb00100.x. ISSN 1080-563X. " ...
*  Post-chemotherapy cognitive impairment
Modafinil is a wakefulness-promoting agent that can improve alertness and concentration, and studies have shown it to be ... Other chemotherapy agents such as BCNU, cisplatin, and cytarabine also displayed toxicity to progenitor cells in vivo and in ... Methotrexate, an agent widely used in the chemotherapy treatment of breast cancer, has also displayed a long-lasting dose ... In most cases there is no known way of reducing the effects of chemotherapeutic agents related to taxanes, thalidomide and ...
*  Norepinephrine releasing agent
... aminorex As wakefulness-promoting agents in the treatment of narcolepsy - e.g., amphetamine, methamphetamine As nasal ... Monoamine releasing agent Serotonin releasing agent Dopamine releasing agent Keith Parker; Laurence Brunton; Goodman, Louis ... A norepinephrine releasing agent (NRA), also known as an adrenergic releasing agent, is a catecholaminergic type of drug which ...
*  Arylalkylamine
... wakefulness-promoting agents, bronchodilators, decongestants, antidepressants, entactogens, and psychedelics, among others. ...
*  Modafinil
In support of modafinil acting as a dopaminergic agent, its wakefulness-promoting effects are abolished in DAT knockout mice ( ... "Effect of the wake-promoting agent modafinil on sleep-promoting neurons from the ventrolateral preoptic nucleus: an in vitro ... Modafinil, sold under the brand name Provigil among others, is a wakefulness-promoting drug used for treatment of disorders ... However, modafinil sulfone lacks any wakefulness-promoting effects in animals, indicating that a distinct mechanism may be at ...
*  Neuroenhancement
Modafinil is a wakefulness-promoting drug that decreases fatigue, increases vigilance, reduces daytime sleepiness, and improves ... Critically, for any agent to qualify as a neuroenhancer, it must reliably engender substantial cognitive, affective, or motor ... Pharmalogical neuroenhancement agents include the well-validated nootropics, such as racetam, vinpocetine, and ... Effects on sleep deprived individuals are even more striking: a single dose resulted in enhanced wakefulness, executive ...
*  Idiopathic hypersomnia
... will be particularly useful as wake-promoting agents in the treatment of idiopathic hypersomnia. Given the possible role of ... "As the brain systems regulating sleepiness and wakefulness are better understood, scientists will be in a better position to ... compounds such as pitolisant that promote the release of the wake-promoting amine histamine) ... Therefore, the wake-promoting medications used in narcolepsy are also commonly used off-label to help manage the excessive ...
*  Narcolepsy
... will be particularly useful as wake-promoting agents. Given the possible role of hyper-active GABAA receptors in the primary ... Periods of wakefulness at night Sleep paralysis is the temporary inability to talk or move when waking (or less often, when ... compounds such as pitolisant that promote the release of the wake-promoting amine histamine) ... For example, the lack of muscular control can occur during wakefulness in a cataplexy episode; it is said that there is ...
*  Circadian rhythm sleep disorder
Medications such as melatonin and modafinil (Provigil), or other short term sleep aids or wake-promoting agents can be ... Thus, a person's body is ready for sleep and for wakefulness at relatively specific times of the day. Sleep researcher Yaron ...
*  Neuropeptide S
Reinscheid RK, Xu YL (Nov 2005). "Neuropeptide S as a novel arousal promoting peptide transmitter". The FEBS Journal. 272 (22 ... Animal studies show that NPS suppresses anxiety and appetite, induces wakefulness and hyperactivity, including hyper-sexuality ... "Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice". British Journal of Pharmacology. 154 (2): 471-9 ... a neuropeptide promoting arousal and anxiolytic-like effects". Neuron. 43 (4): 487-97. doi:10.1016/j.neuron.2004.08.005. PMID ...
*  Miodrag Radulovacki
This approach was of interest since Michel Jouvet's Monoamine Theory of Sleep, with serotonin as the sleep inducing agent, was ... Radulovacki died on May 27, 2014 in Belgrade, Serbia, while on two-week trip to promote his philanthropic projects. He is ... The cannulation method enabled researchers to obtain cerebrospinal fluid during sleep and wakefulness for the analysis of ... Radulovacki, M (1973). "5-Hydroxyindoleacetic acid in cerebrospinal fluid: Measurements in wakefulness, slow-wave and ...
*  Legal intoxicant
... noted for its ability to promote wakefulness and provide energy. Caffeine is legal and unrestricted in all countries and ... and as a fever-reducing agent. Its psychedelic properties do not become apparent until the user is asleep. Hawaiian baby ...
*  Protriptyline
... and is sometimes used for narcolepsy to achieve a wakefulness-promoting effect. TCAs including protriptyline are also used to ... but protriptyline is considered the least sedating agent among this class of agents. Its side effects are especially noticeable ... 836-. ISBN 978-0-7817-2845-4. I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: ...
*  Adderall
... wakefulness), in turn promoting goal-directed behavior. Stimulants such as amphetamine can improve performance on difficult and ... Gastrointestinal alkalizing (acidifying) agents increase (decrease) absorption. Urinary alkalizing (acidifying) agents increase ... Such agents also have important therapeutic uses; cocaine, for example, is used as a local anesthetic (Chapter 2), and ... Duration of effect varies depending on agent and urine pH. Excretion is enhanced in more acidic urine. Half-life is 7 to 34 ...
*  Hypnotic
... agents. Once again, longer-term randomized, double-blind, controlled studies that demonstrate efficacy of these agents have not ... promotes sleep in diurnal mammals. In common use, the term antihistamine refers only to compounds that inhibit action at the H1 ... reducing wakefulness. Like alcohol, benzodiazepines are commonly used to treat insomnia in the short-term (both prescribed and ... Wagner, J.; Wagner, M. L.; Hening, W. A. (June 1998). "Beyond benzodiazepines: alternative pharmacologic agents for the ...
*  Effects of sleep deprivation on cognitive performance
... with 19 hours of wakefulness corresponding to a BAC of 0.05%, and 24 hours of wakefulness corresponding to a BAC of 0.10%. ... The game involved subjects promoting a fictional product while getting feedback on the financial effects of their decisions. ... thus increasing the susceptibility of the brain to other neurochemical agents that can cause amnesia. Further research has ... These images were taken during rested wakefulness and again after one night of sleep deprivation. The thalamus is more highly ...
*  Norepinephrine
It runs at a baseline level during wakefulness, but increases temporarily when a person is presented with any sort of stimulus ... Surviving Sepsis Campaign recommended norepinephrine as first line agent in treating septic shock which is unresponsive to ... In the brain, norepinephrine increases arousal and alertness, promotes vigilance, enhances formation and retrieval of memory, ... Norepinephrine release is lowest during sleep, rises during wakefulness, and reaches much higher levels during situations of ...