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*  Factor VIII
In response to injury, coagulation factor VIII is activated and separates from von Willebrand factor. The active protein ( ... it mainly circulates in a stable noncovalent complex with von Willebrand factor. Upon activation by thrombin (factor IIa), it ... This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until ... Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII ...
*  GP1BA
Titani K, Takio K, Handa M, Ruggeri ZM (1987). "Amino acid sequence of the von Willebrand factor-binding domain of platelet ... The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent ... Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib- ... Effects of leukocyte elastase and other proteases on platelets response to von Willebrand factor and thrombin". Eur. J. Biochem ...
*  Von Willebrand factor
Includes: Type 1 von Willebrand Disease, Type 2A von Willebrand Disease, Type 2B von Willebrand Disease, Type 2M von Willebrand ... Von Willebrand factor's primary function is binding to other proteins, in particular factor VIII, and it is important in ... Although von Willebrand could not identify the definite cause, he distinguished von Willebrand disease (vWD) from hemophilia ... which binds to factor VIII (Von Willebrand factor type D domain) the A1 domain, which binds to: platelet GPIb-receptor heparin ...
*  Von Willebrand factor type A domain
"The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform ... In von Willebrand factor, the type A domain (vWF) is the prototype for a protein superfamily. The vWF domain is found in ... The von Willebrand factor is a large multimeric glycoprotein found in blood plasma. Mutant forms are involved in the aetiology ... Perkins SJ, Edwards YJ (1995). "The protein fold of the von Willebrand factor type A domain is predicted to be similar to the ...
*  Von Willebrand factor type D domain
... the protein domain Von Willebrand factor type D domain belongs to a large family of proteins, named, the von Willebrand factor ... One of the functions of von Willebrand factor (vWF) is to serve as a carrier of clotting factor VIII (FVIII). The native ... domain of von Willebrand factor induced by CYS 25 and CYS 95 mutations lead to factor VIII binding defect and multimeric ... "The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform ...
*  Von Willebrand factor type C domain
Von Willebrand factor C and EGF domain-containing protein (VWCE) Von Willebrand factor (VWF) Chordin (CHRD) Chordin-like 1 ( ... Von Willebrand factor, type C (VWFC or VWC)is a protein domain is found in various blood plasma proteins: complement factors B ... "The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform ... For the von Willebrand factor the duplicated VWFC domain is thought to participate in oligomerization, but not in the initial ...
*  Von willebrand factor a domain containing 7
See articles on Von Willebrand factor and on Von Willebrand factor type A domain. ENSG00000223757, ENSG00000227144, ... Von Willebrand factor A domain containing 7 is a protein that in humans is encoded by the VWA7 gene. ... Von Willebrand factor A domain containing 7". Retrieved 2016-07-25. Valdes AM, Thomson G (2009). "Several loci in the HLA class ...
*  Primary hypertrophic osteoathropathy
In contrast to HPGD mutations, suspected mutations for these factors have not been reported yet. Von Willebrand factor is a ... such as Von Willebrand factor and vascular endothelial growth factor (VEGF). These substances could also have a role in PDP ... 1992). "Von Willebrand factor antigen in hypertrophic osteoarthropathy". J Rheumatol. 19: 765-767. Silveria LH, et al. (2000 ... platelet-derived growth factor (PDGF) and epidermal growth factor (EGF). It has not been described yet what role these ...
*  ADAMTS13
... also known as von Willebrand factor-cleaving protease (VWFCP)-is a zinc-containing metalloprotease enzyme that cleaves von ... Fujimura Y, Matsumoto M, Yagi H, Yoshioka A, Matsui T, Titani K (January 2002). "Von Willebrand factor-cleaving protease and ... Kremer Hovinga JA, Studt JD, Lämmle B (2005). "The von Willebrand factor-cleaving protease (ADAMTS-13) and the diagnosis of ... Sonneveld MA, de Maat MP, Leebeek FW (July 2014). "Von Willebrand factor and ADAMTS13 in arterial thrombosis: a systematic ...
*  List of autoimmune diseases
Moake JL (2004). "von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura". Seminars in Hematology. 41 (1): 4 ... "Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic ... 173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis". Arthritis ...
*  VWA2
von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen ... AMACO is a member of the von Willebrand factor A-like (VWA) domain containing protein superfamily and consists of three VWA- ... von Willebrand factor A domain containing 2". Sengle G, Kobbe B, Morgelin M, Paulsson M, Wagener R (December 2003). " ... a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney". J. Biol ...
*  Matrilin-2
This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought ... This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two ... the closest relative of cartilage matrix protein within the von Willebrand factor type A-like module superfamily". J Biol Chem ...
*  Atypical hemolytic uremic syndrome
Moake, JL (2004). "von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura". Semin Hematol. 41 (1): 4-14. doi ... factor H, factor HR1 or HR3, membrane cofactor protein, factor I, factor B, complement C3, and thrombomodulin). This results in ... an enzyme that cleaves von Willebrand factor (vWf), a large protein involved in blood clotting, into smaller pieces. (TTP also ... The complement system activation may be due to mutations in the complement regulatory proteins (factor H, factor I, or membrane ...
*  Caplacizumab
It is an anti-von Willebrand factor humanized immunoglobulin. It acts by blocking platelet aggregation to reduce organ injury ...
*  VWA5A
Von Willebrand factor A domain containing 5A is a protein that in humans is encoded by the VWA5A gene. GRCh38: Ensembl release ... Von Willebrand factor A domain containing 5A". Retrieved 2017-06-06. Zhou YQ, Chen SL, Ju JY, Shen L, Liu Y, Zhen S, Lv N, He ...
*  Plasmin
It cleaves fibrin, fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin, like trypsin, belongs to the ... and factor XII (Hageman factor). Fibrin is a cofactor for plasminogen activation by tissue plasminogen activator. Urokinase ... "Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice". Proc. Natl. Acad. Sci. U.S. ... "Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3". Am. J. Physiol. 275 (2 Pt 1): ...
*  Biochemical cascade
The von Willebrand factor (VWF) serves as an essential accessory molecule. In general terms, platelet activation initiated by ... FGF (Fibroblast Growth Factor) ligands bind to receptors tyrosine kinase, FGFR (Fibroblast Growth Factor Receptors), and form a ... "Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory ... They are involved in regulation of kinases and phosphatases, G protein associated factors and transcriptional factors. Gaseous ...
*  Calcium in biology
An example a protein with calcium coordination is von Willebrand factor (vWF) which has an essential role in blood clot ... Calcium modulates force sensing by the von Willebrand factor A2 domain. Nature Commun. 2011 Jul 12;2:385. [1] Dietary Reference ...
*  Oprelvekin
Healthy volunteers displayed an increase in von-Willebrand-factor (vWf) activity. Isolated molecules formed under Oprelvekin ... IL-11 is a member of a family of human growth factors and is being produced in the bone marrow of healthy adults. Synonyms are ... These increases in coagulation factors may contribute to the development of stroke (see under side-effects), but a precise ... Oprelvekin is recombinant interleukin eleven (IL-11), a thrombopoietic growth factor that directly stimulates the proliferation ...
*  Protein folding
von Willebrand factor (vWF) is a protein with an essential role in blood clot formation process. It discovered - using single ... Jakobi AJ, Mashaghi A, Tans SJ, Huizinga EG (July 2011). "Calcium modulates force sensing by the von Willebrand factor A2 ... This can be due to mutations in the amino acid sequence or a disruption of the normal folding process by external factors. The ... The external factors involved in protein denaturation or disruption of the native state include temperature, external fields ( ...
*  Fresh frozen plasma
Cryoprecipitate should be used when fibrinogen or von Willebrand factor is needed. For treatment of hemophilia A, ... Replacement of isolated factor deficiencies FFP is used to treat rare bleeding disorders when specific factor concentrates are ... cryoprecipitate or factor VIII concentrates, heated or unheated, are available. For treatment of severe hemophilia B, factor IX ... It is used to treat conditions in which there are low blood clotting factors (INR>1.5) or low levels of other blood proteins. ...
*  Mica
Marchant, R. E.; Lea, A. S.; Andrade, J. D.; Bockenstedt, P. (1992). "Interactions of von Willebrand factor on mica studied by ...
*  Dextran
... s also reduce factor VIII-Ag Von Willebrand factor, thereby decreasing platelet function. Clots formed after ... and in certain intravenous fluids to solubilize other factors, such as iron (in a solution known as Iron Dextran). Intravenous ...
*  ABO blood group system
March 2005). "The prevalence of the cysteine1584 variant of von Willebrand factor is increased in type 1 von Willebrand disease ... von Willebrand factor is modifiedby ABO blood group genotype and is a major determinant of plasma von Willebrand factor antigen ... O'Donnell, J; Laffan MA (August 2001). "The relationship between ABO histo-blood group, factor VIII and von Willebrand factor ... 2006). "High von Willebrand factor levels increase the risk of first ischemic stroke: influence of ADAMTS13, inflammation, and ...
*  Von Willebrand disease
Since this time, the factor causing the long bleeding time was called the "von Willebrand factor" in honor of Dr. Erik von ... Sadler JE (1994). "A revised classification of von Willebrand disease. For the Subcommittee on von Willebrand Factor of the ... The von Willebrand factor is undetectable in the vWF antigen assay. Since the vWF protects coagulation factor VIII from ... Von Willebrand disease (vWD) (/ˌfʌnˈvɪlɪbrɑːnt/), discovered by Erik Adolf von Willebrand, is the most common hereditary blood- ...
*  AP-1 transcription factor
Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers ... "The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors". Oncogene. 27 (3): 366-377. doi: ... The growth factors TGF alpha, TGF beta, and IL2 have all been shown to stimulate c-Fos, and thereby stimulate cellular ... AP-1 transcription factor has been shown to have a hand in a wide range of cellular processes, including cell growth, ...
*  Matrilin-1
This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins are thought to ... the closest relative of cartilage matrix protein within the von Willebrand factor type A-like module superfamily". J. Biol. ... the closest relative of cartilage matrix protein within the von Willebrand factor type A-like module superfamily". J. Biol. ...