*  Factor VIII
This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until ... Factor VIII is not affected by liver disease. In fact, levels usually are elevated in such instances. FVIII concentrated from ... In the blood, it mainly circulates in a stable noncovalent complex with von Willebrand factor. Upon activation by thrombin ( ... In response to injury, coagulation factor VIII is activated and separates from von Willebrand factor. The active protein ( ...
*  GP1BA
... some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. GP1BA has been shown to ... "Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease". Proc. Natl ... Titani K, Takio K, Handa M, Ruggeri ZM (1987). "Amino acid sequence of the von Willebrand factor-binding domain of platelet ... The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent ...
*  Von Willebrand disease
"Von Willebrand Disease". Mayo Clinic. Retrieved 1 December 2017. "Molecular basis of von Willebrand disease and its clinical ... Von Willebrand disease (vWD) (/ˌfʌnˈvɪlɪbrɑːnt/), discovered by Erik Adolf von Willebrand, is the most common hereditary blood- ... "Canine von Willebrand Disease - Breed Summaries". ahdc.vet.cornell.edu. Von Willebrand, EA (May 1999). "Hereditary ... Sadler JE (1994). "A revised classification of von Willebrand disease. For the Subcommittee on von Willebrand Factor of the ...
*  DMOZ - Health: Animal: Mammals: Dogs: Conditions and Diseases: von Willebrand Disease
An inherited bleeding disorder caused by a reduction in the amount or function of von Willebrand factor (vWF), which is ... "Health ... von Willebrand Disease" search on: AOL - Ask - Bing - DuckDuckGo - Gigablast - Google - ixquick - Yahoo - Yandex - ... An inherited bleeding disorder caused by a reduction in the amount or function of von Willebrand factor (vWF), which is ... Information on this disease from the Jack Russell Terrier Club of America. ...
*  DMOZ - Health: Conditions and Diseases: Blood Disorders: von Willebrand
Patients with this disease have diminished production of von Willebrand factor or produce a molecule that does not function ... There are different types of this disease They vary in severity and require different treatments. ... Patients with this disease have diminished production of von Willebrand factor or produce a molecule that does not function ... Canadian Hemophilia Society: Von Willebrand Disease Offers information about this common bleeding disorder. Includes the types ...
*  Miniature Schnauzer
"von Willebrand's Disease". Disease Information. American Kennel Club Canine Health Foundation. Archived from the original on 4 ... Miniature Schnauzers are also prone to von Willebrand disease (vWD). vWD in dogs is an inherited bleeding disorder that occurs ... due to qualitative or quantitative deficiency of von Willebrand factor (vWF), a multimeric protein that is required for ...
*  Shetland Sheepdog
Von Willebrand disease is an inherited bleeding disorder. In Shelties, affected dogs as a general rule are not viable and do ... "Von Willebrand's Disease". Retrieved 2 April 2011. "Canine Hypothyroidism". Retrieved 2 April 2011. "Canine Hip Dysplasia". ... Brewer, George J. "Sheltie von Willebrand's Disease". vetGen. Retrieved April 4, 2011. Julie B. Anderson; Kenneth S. Latimer; ... Both male and female should be tested for thyroid problems, Von Willebrands disease and brucellosis, as well as have hip x-rays ...
*  Akita (dog)
Von Willebrands disease, a genetic bleeding disorder caused by a deficiency in Von Willebrand factor. Cushing's Syndrome also ... "Von Willebrand Disease" (pdf). The Furry Critter Network. Retrieved 5 April 2011. Brooks, M. (1999). "A review of canine ... Anderson, Julie B.; Latimer, Kenneth S.; Bain, Perry J.; Tarpley, Heather L. "Von Willebrand's Disease" (website). Veterinary ... Systemic lupus erythematosus (SLE), or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) that ...
*  Chesapeake Bay Retriever
These include, but are not limited to: Hip dysplasia Progressive retinal atrophy Type 3 von Willebrand disease Cataract ... LJohnson GS; Turrentine MA; Kraus, KH (1988). "Canine von Willebrand's disease". Veterinary Clinics of North America. 18: 195- ... ISBN 0-87605-099-2. LaFond E, Breur GJ, Austin CC (2002). "Breed susceptibility for developmental orthopedic diseases in dogs ... The breed is subject to a number of hereditary diseases. ...
*  Bleeding diathesis
May 16, 2009 Von Willebrand disease --> Complications By Mayo Clinic staff. Feb. 7, 2009. ... Various types of Hemophilia and von Willebrand disease are the major genetic disorders associated with coagulopathy.Rare ...
*  Platelet
1992). "Acquired von Willebrand's disease in association with essential thrombocythemia: Regression following treatment". Acta ... van Genderen PJ; Leenknegt H; Michiels JJ; Budde U (1996). "Acquired von Willebrand disease in myeloproliferative disorders". ... An elevated CT with EPI and collagen can indicate intrinsic defects such as von Willebrand disease, uremia, or circulating ... The excessive numbers create a relative von Willebrand factor deficiency due to sequestration.) One can get a clue as to ...
*  Haemophilia
"Haemophilia Special Issue: von Willebrand's Disease: a Report from a Meeting in the Åland Islands". Haemophilia. 18. doi: ... This bleeding disorder is called "Von Willebrand Disease". The term "haemophilia" is derived from the term "haemorrhaphilia" ... His sons, however, will not be affected with the disease. The disease is X-linked and the father cannot pass haemophilia ... Zielbauer, Paul von (4 September 2006). "Iraqis Infected by H.I.V.-Tainted Blood Try New Tool: A Lawsuit". The New York Times. ...
*  Bleeding
Another common bleeding disorder is Von Willebrand disease. It is caused by a deficiency or abnormal function of the "Von ... This is a rare condition that is most likely to occur in older patients and in those with autoimmune diseases. ... For instance, deficiency of Factor VIII causes classic hemophilia A while deficiencies of Factor IX cause "Christmas disease"( ... Willebrand" factor, which is involved in platelet activation. Deficiencies in other factors, such as factor XIII or factor VII ...
*  Antiplatelet drug
Von Willebrand's disease) and idiopathic thrombocytopenic purpura. Food and supplements that may increase antiplatelet drugs ... Peripheral Vascular Disease/Peripheral Arterial Disease and apical/ventricular/mural thrombus. Treatment of established ... IIb/IIIa complex Glycoprotein IIb/IIIa receptor antagonists block a receptor on the platelet for fibrinogen and von Willebrand ... Medical conditions that may increase antiplatelet drugs effect: Chronic renal failure, liver disease, haematological malignancy ...
*  Valentin Fuster
"Resistance to Arteriosclerosis in Pigs with von Willebrand's Disease". Journal of Clinical Investigation. 61 (3): 722-30. doi: ... Fuster, V; Fass, DN; Kaye, MP; Josa, M; Zinsmeister, AR; Bowie, EJ (Nov 1982). "Arteriosclerosis in normal and von Willebrand ... In fact, many studies show that childhood obesity leads to cardiovascular disease, thru an increase in cardiovascular disease ... He specializes in the prevention and treatment of heart disease, coronary artery disease, atherosclerosis, and thrombosis. Dr. ...
*  Hemostasis
New research is concluding that the von Willebrand disease is much more common in adolescence. This disease negatively hinders ... Von Willebrand disease is associated with a defect in the ability of the body to create the platelet plug and the fibrin mesh ... Mikhail, Sameh; Kouides, Peter (December 2010). "von Willebrand Disease in the Pediatric and Adolescent Population". Journal of ... and Von Willebrand factor concentrates. Current research is trying to find better ways to deal with this disease; however, much ...
*  Weibel-Palade body
Type III von Willebrand Disease is a severe bleeding disorder, like severe hemophilia type A or B. VWF acts in primary ... Mutations within vWF are the usual cause of the most common inherited bleeding disorder, von Willebrand disease. VWD has an ... a window to von Willebrand disease". Journal of Thrombosis and Haemostasis. 11 (4): 581-592. doi:10.1111/jth.12160. ISSN 1538- ... One is von Willebrand factor (vWF), a multimeric protein that plays a major role in blood coagulation. Storage of long polymers ...
*  Cryoprecipitate
von Willebrand disease - Not currently recommended unless last reserve. ddAVP is first line, followed by factor concentrates. ... Fibrinogen 150-250 mg with a half-life of 100-150 hours Factor VIII 80-150 U with a half-life of 12 hours von Willebrand factor ... transfusion-associated graft-versus-host disease, and post-transfusion purpura. "CRYO (cryoprecipitate) pharmacology". Medscape ...
*  Toy Fox Terrier
Legg-Calvé-Perthes syndrome and von Willebrand's disease are uncommon. Some dogs are allergic to beet pulp, corn, and wheat. ... tartar build-up that can lead to periodontal disease. As well, daily brushing has been shown to be very beneficial as well as ...
*  Glycoprotein Ib
A gain-of-function mutation causes platelet-type von Willebrand's disease. Autoantibodies against Ib/IX can be produced in ... The GPIb-V-IX complex binds von Willebrand factor, allowing platelet adhesion and platelet plug formation at sites of vascular ...
*  Multiple electrode aggregometry
... as seen in von Willebrand disease (vWD), or absence or reduction in numbers of GP1b receptors, as in Bernard-Soulier syndrome ( ... a new tool for von Willebrand disease". Journal of thrombosis and haemostasis. 9 (2011 Aug;9(8)): 1645-7. doi:10.1111/j.1538- ... Ristocetin forms complexes with von Willebrand Factor (vWF) that bind to the glycoprotein Ib (GP1b) receptors on platelets, ... Sibbing, D; Morath, T; Braun, S; Stegherr, J; Mehilli, J; Vogt, W; Schömig, A; Kastrati, A; von Beckerath, N (2010). " ...
*  Factor VIII (medication)
Certain preparations may also be used in those with von Willebrand's disease. It is given by slow injection into a vein. Side ... This transfer of a plasma byproduct into the blood stream of a hemophiliac often led to the transmission of diseases such as ... which now prevent nearly all forms of disease transmission during replacement therapy. "Coagulation Factor VIII, Human - Drugs. ...
*  Turoctocog alfa
... is not indicated for the treatment of von Willebrand disease. In a study conducted with 150 patients aged 12 ...
*  Erik Jorpes
He also worked on von Willebrand disease with Erik Adolf von Willebrand. In 1961, Jorpes and the docent Viktor Mutt isolated ...
*  Keeshond
Cushing's disease, diabetes, primary hyperparathyroidism, and hypothyroidism. Von Willebrand's disease has been known in ...
*  AP-1 transcription factor
Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers ... Stark CJ, Atreya CD (2005). "Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies". ... von Knethen A, Callsen D, Brüne B (February 1999). "NF-kappaB and AP-1 activation by nitric oxide attenuated apoptotic cell ...
*  ADAMTS13
This phenomenon is characterised by a form of von Willebrand disease (type 2a). ADAMTS5 ENSG00000281244 GRCh38: Ensembl release ... also known as von Willebrand factor-cleaving protease (VWFCP)-is a zinc-containing metalloprotease enzyme that cleaves von ... Fujimura Y, Matsumoto M, Yagi H, Yoshioka A, Matsui T, Titani K (January 2002). "Von Willebrand factor-cleaving protease and ... Kremer Hovinga JA, Studt JD, Lämmle B (2005). "The von Willebrand factor-cleaving protease (ADAMTS-13) and the diagnosis of ...