... binding sites are predominantly found in talin and talin-like molecules, enabling binding of vinculin to talin, ... These changes occur when vinculin interacts with focal adhesion points to which it is binding to. When vinculin resides in its ... The combinatorial model of vinculin states that either α-actinin or talin can activate vinculin either alone or with the ... Feramisco JR, Smart JE, Burridge K, Helfman DM, Thomas GP (September 1982). "Co-existence of vinculin and a vinculin-like ...

Vinculin is located at the cytoplasmic side of focal contacts or adhesion plaques. In addition to actin, vinculin interacts ... Vinculin InterPro: IPR000633 Alpha-catenin InterPro: IPR001033 CTNNA1; CTNNA2; CTNNA3; CTNNAL1; VCL; Otto JJ (1990). "Vinculin ... Vinculin is a eukaryotic protein that seems to be involved in the attachment of the actin-based microfilaments to the plasma ... Vinculin is a large protein of 116 kDa (about a 1000 residues). Structurally the protein consists of an acidic N-terminal ...

Goldmann WH, Niggli V, Kaufmann S, Isenberg G (Aug 1992). "Probing actin and liposome interaction of talin and talin-vinculin ... Bass MD, Smith BJ, Prigent SA, Critchley DR (Jul 1999). "Talin contains three similar vinculin-binding sites predicted to form ... The rod domain (>200 kDa) has considerable flexibility and houses a conserved actin binding site, three vinculin binding sites ... Burridge K, Mangeat P (1984). "An interaction between vinculin and talin". Nature. 308 (5961): 744-6. Bibcode:1984Natur.308.. ...

Vinculin binding sites are protein domains predominantly found in talin and talin-like molecules, enabling binding of vinculin ... conformational change within the vinculin head domain thereby displacing the intramolecular interaction with the vinculin tail ... It contains a vinculin binding site (VBS) composed of a hydrophobic surface spanning five turns of helix four. Activation of ... August 2004). "Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle". The EMBO ...

Rangarajan ES, Izard T (April 2012). "α-Catenin unfurls upon binding to vinculin". J Biol Chem. 287 (22): 18492-9. doi:10.1074/ ... it is likely that α-catenin acts in concert with vinculin to bind to actin and help stabilize the junctions. F9 embryonal ...

They likely do not possess vinculin proteins. Their metabolism relies on fermentative production of ATP as an adaptation to ...

vinculin showed a similar profile of change. N-cadherin showed no change, and there was no compensatory upregulation of ... Hazan RB, Kang L, Roe S, Borgen PI, Rimm DL (December 1997). "Vinculin is associated with the E-cadherin adhesion complex". The ...

Zemljic-Harpf A, Manso AM, Ross RS (Dec 2009). "Vinculin and talin: focus on the myocardium". Journal of Investigative Medicine ... Critchley DR (Nov 2004). "Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion". Biochemical Society ... "Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site". Journal of Cell Science. 109 ( ...

The SH3 domains interact with Arg/Abl, vinculin. The SOHO domain interacts with flotillin found in lipid rafts. The subcellular ... In cardiac muscle cells, pull-down experiments discovered ArgBP2 in complex with alpha actinin-2, vinculin, spectrin, paxillin ...

Expression of vinculin in muscle cells was strikingly down-regulated. Through the use of gold-immunoelectron microscopy, ... Plectin binds several proteins, including vinculin, DES, actin., fodrin, microtubule-associating proteins, nuclear laminin B., ... and vinculin". European Journal of Cell Biology. 38 (1): 113-22. PMID 2992982. Hijikata T, Murakami T, Imamura M, Fujimaki N, ...

Fausser JL, Ungewickell E, Ruch JV, Lesot H (1994). "Interaction of vinculin with the clathrin heavy chain". J. Biochem. 114 (4 ...

The binding of vinculin to α-catenin offers the protein complex another linkage with actin in addition to recruiting proteins ... Hazan RB, Kang L, Roe S, Borgen PI, Rimm DL (December 1997). "Vinculin is associated with the E-cadherin adhesion complex". The ... July 2010). "Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics". Nature. 466 (7303): ... Vinculin, PTPmu(PTPRM) PTPrho(PTPRT) Loss of E-cadherin function or expression has been implicated in cancer progression and ...

The other complex is the integrin-vinculin-talin complex. The dystrophin-associated protein complex includes dystrophin. ...

Huang DL, Bax NA, Buckley CD, Weis WI, Dunn AR (August 2017). "Vinculin forms a directionally asymmetric catch bond with F- ... vinculin with F-actin, microtubule with kinetochore particle, integrin alpha L beta 2 and intercellular adhesion molecule 1 ( ...

Turner CE, Glenney JR, Burridge K; Glenney Jr; Burridge (September 1990). "Paxillin: a new vinculin-binding protein present in ... While developing a procedure to purify α-actinin from smooth muscle, Burridge co-purified another protein, vinculin, ... His research on focal adhesions includes the discovery of many adhesion proteins including vinculin, talin and paxillin, and ...

Turner CE, Glenney JR, Burridge K (1990). "Paxillin: a new vinculin-binding protein present in focal adhesions". J. Cell Biol. ... The current working model of costamerogenesis is that in cultured, undifferentiated myoblasts, alpha-5 integrin, vinculin and ... such as vinculin and actopaxin, and regulators of actin organization, such as COOL/PIX and PKL/GIT. Paxillin is tyrosine- ... identification of a vinculin and pp125Fak-binding region". Journal of Cell Science. 107 (6): 1583-91. doi:10.1242/jcs.107.6. ...

αE-catenin is highly expressed in cardiac muscle and is homologous to the protein vinculin; however, aside from vinculin, αE- ... Nagafuchi A, Takeichi M, Tsukita S (1991). "The 102 kd cadherin-associated protein: similarity to vinculin and ... "alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells". J. Cell Biol. 142 ... "The uvomorulin-anchorage protein alpha-catenin is a vinculin homologue". Proc Natl Acad Sci U S A. 88 (20): 9156-60. Bibcode: ...

"The uvomorulin-anchorage protein alpha catenin is a vinculin homologue". Proceedings of the National Academy of Sciences of the ...

1 July 2010). "Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics". Nature. 466 (7303 ...

EPLIN has been found to enhance the bundling and stabilization of actin filaments, and vinculin is involved in the linkage of ... Recently, α-catenin has been shown to associate with formins, EPLIN, and vinculin. ...

alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells. J Cell Biol. 1998; ... It has been reported that the actin binding proteins vinculin and α-actinin can bind to alpha-catenin. It has been suggested ... 8. Weiss EE, Kroemker M, Rudiger AH, Jockusch BM, Rudiger M. Vinculin is part of the cadherin-catenin junctional complex: ... An autoinhibited structure of alpha-catenin and its implications for vinculin recruitment to adherens junctions. J Biol Chem. ...

... a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization". J Cell Biol. 144 (1): 59- ...

Additional components of focal adhesions include actin, filamin, vinculin, talin, paxillin, tensin and RSU-1. FAK is ... determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and ...

... has been shown to interact with: CBL, FLOT1, INPPL1, INSM1, MLLT4, PXN, and Vinculin. GRCh38: Ensembl release 89: ... and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions". The Journal of Cell Biology. 144 (5): ...

Yürüker B, Niggli V (February 1992). "Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and ...

Yürüker B, Niggli V (1992). "Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to ...

α {\displaystyle \alpha } -catenin is engaged by p120-catenin complex, where vinculin is recruited to take a role in indirect ... However, cadherin-catenin complex can also bind directly to the actin without the help of vinculin. Moreover, the strength of ... and vinculin. Binding of p-120 catenin and β {\displaystyle \beta } -catenin to the homodimer increases the stability of the ... catenin and vinculin. Cadherins behave as both receptors and ligands for other molecules. During development, their behavior ...

Yürüker B, Niggli V (1992). "Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to ...

Kawai S, Enzan H, Hayashi Y, Jin YL, Guo LM, Miyazaki E, Toi M, Kuroda N, Hiroi M, Saibara T, Nakayama H (2003). "Vinculin: a ...

"Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers". Virchows Archiv. 443 (1 ...