"Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in ... A key interest in TBK1 is due to its role in innate immunity, especially in antiviral responses. TBK1 is redundant with IKK ϵ ... In contrast, binding to NAP1 and SINTBAD leads to localization in the cytoplasm and involvement in autophagy. Another adaptor ... TBK1 is involved in many signaling pathways and forms a node between them. For this reason, regulation of its involvement in ...

In the context of viral infection vesicular stomatitis virus (VSV) challenge of murine peritoneal macrophages was reported to ... In DNA viruses, miRNAs were experimentally verified, miRNAs in viruses are encoded by dsDNAs, examples of such viruses include ... These investigators found that forced expression of miR-155-5p in bone marrow cells resulted in a ~50% decrease in SPI1 (i.e. ... Viruses can exploit host miRNAs to the degree that they use host miRNAs to encode for viral clones for example: miR-K12-11 in ...

In collaboration with Alice S. Huang, Reiss's lab studied viral encephalitis, the pathogenesis of Vesicular Stomatitis Virus ( ... In addition to the department of biology, she has faculty appointments in neural science in NYU's Faculty of Arts and Science, ... in biology, 1972), Sarah Lawrence College (M.S. in human genetics, 1973). She earned a Ph.D. in microbiology from Mount Sinai ... Reiss was editor-in-chief of the journal Viral Immunology (2000-2006) and is currently editor-in-chief of the journal DNA and ...

Huang also moved to MIT to continue her research on vesicular stomatitis virus (VSV). They became a couple, and married in ... 2 articles by Luke Frankiw published in 2019 and 2020). In an autobiographical piece published in Annual Review Immunology in ... The infectious clone, DNA encoding the genome of a virus, is a standard tool used today in virology. In 1982, with a charitable ... He also continued to pursue fundamental questions in RNA viruses and in 1981, Baltimore and Vincent Racaniello, a post-doctoral ...

... protects against viruses such as encephalomyocarditis virus and vesicular stomatitis virus as well as the hepatitis B virus in ... The receptor is expressed largely in epithelial cells, specifically keratinocytes and melanocytes found in the epidermis. The ... In binding to the receptor, interferon lambdas inhibit cell growth and the cell begins to produce cellular receptors that can ... Cells such as those in the central nervous system, uterus, bone marrow, testis and skeletal muscle have low mRNA levels and do ...

... particles of vesicular stomatitis virus in electron micrographs, and the DIP terminology was formalized in 1970 by Huang and ... Hackett AJ (September 1964). "A possible morphologic basis for the autointerference phenomenon in vesicular stomatitis virus". ... "Propagation of the PR8 strain of influenza A virus in chick embryos. III. Properties of the incomplete virus produced in serial ... In molecular genetics terms, the wild-type virus is said to provide complementation in trans. Interference via competitive ...

"Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo ... During this stage, viruses leave the original host cell in search of a new host. In the case of neurotropic viruses, this ... Vesicular stomatitis virus (Rhabdoviridae family) - anterograde. Sindbis virus (Togaviridae family) - anterograde with small ... In nature, neurotropic viruses are usually transmitted through bites or scratches, as in the case of the rabies virus or ...

... virus is classified in the Rhabdoviridae family and is related to the viral agents that cause rabies and vesicular stomatitis. ... The Flanders virus was named after the town in which it was first discovered in 1960. This town, in New York is a hamlet that ... Symptoms specific to the HP virus in humans have not been conclusive, however; symptoms of RNA viruses include: hepatitis, ... The Flanders virus is similar to the antigentic make-up of the Hart Park virus. Both the HP and Flanders viruses are part of ...

In 2005, two reports have shown that vesicular stomatitis virus (VSV), an arbovirus with a many invertebrate and vertebrate ... In 2011 the first naturally associated virus was isolated from C. elegans found outside of a laboratory. The Orsay virus is an ... The resulting change in milieu in the gut leads to germination of the spores, which subsequently proliferate in the worm body. ... In nature C. elegans harbours a diverse set of microbes. In contrast, C. elegans strains that are cultivated in laboratories ...

... the resulting supernatants were shown to inhibit growth of vesicular stomatitis virus. Those reports also contained the basic ... October 2004). "Interleukin-13 in the skin and interferon-gamma in the liver are key players in immune protection in human ... In the cartoon model, one monomer is shown in red, the other in blue. Cellular responses to IFN-γ are activated through its ... In human epithelial cells, IFN-γ upregulates expression of indoleamine 2,3-dioxygenase, which in turn depletes tryptophan in ...

... in particular they have been shown to carry the vesicular stomatitis virus. Though Chloropidae generally do not attack ... In warm seasons they may emerge in huge numbers and swarm about the eyes, up the nostrils and in the mouths of mammals, ... They sometimes assemble in thousands on walls or windows. Larvae of many species in temperate regions will hibernate in winter ... More rarely they feed in fungi. In a small number of species the larvae are predators and live in the egg cocoons of spiders, ...

Equine encephalosis virus, and epizootic hemorrhagic disease virus. The vesicular stomatitis virus causes disease in cattle, ... Rotavirus Rubella virus Tick-borne encephalitis virus West Nile virus Yellow fever virus Zika virus Animal viruses in Riboviria ... the kingdom Shotokuvirae in Monodnaviria, and many viruses in Varidnaviria. Viruses in Riboviria are associated with a wide ... Tobacco mosaic virus was discovered in 1898 and was the first virus to be discovered. Viruses transmitted by arthropods have ...

"Efficacy of Vesicular Stomatitis Virus-Ebola Virus Postexposure Treatment in Rhesus Macaques Infected With Ebola Virus Makona ... In September 2019, a study published in Cell Reports demonstrated the role of the Ebola virus VP35 protein in its immune ... It was approved for medical use in the European Union in November 2019. It was approved for medical use in the United States in ... In additional studies, antibody responses were assessed in 477 individuals in Liberia, some 500 individuals in Sierra Leone, ...

... such as vesicular stomatitis virus. He also worked on the pleasure circuits underlying sweets. "In Memoriam: Anthony N. van den ... "Using a deadly virus to kill cancer: Scientists experiment with new treatment". Washington Post. Retrieved 13 April 2016. Chu, ... He did research in neuropharmacology, neuroanatomy, and neurophysiology, seeking to understand the basic cellular mechanisms of ... van den Pol received his PhD from Yale in 1977 and did postdoctoral work at Oxford University, Semmelweis University, and ...

The RVSV-EBOV vaccination contained a modified Vesicular-Stomatitis-Virus, which contained a surface protein of Ebola virus. ... The MERS Virus vaccine was tested in camels, the animals which first spread MERS coronavirus EMC/2012, in 2016, and started ... In 1999, she moved to Boston, where she specialised in infectious diseases at the Harvard Medical School. Whilst at Harvard ... The vaccine is vector-based, where the DNA of a virus is introduced into human cells via a different virus. To be effective the ...

G-protein of Vesicular stomatitis virus. These substitutions will result in functional virons.[citation needed] Baculovirus ... Starting in the 1940s, the viruses were used and studied widely as biopesticides in crop fields. Since the 1990s, they have ... The baculovirus lifecycle involves two distinct forms of virus. Occlusion-derived virus (ODV) is present in a protein matrix ( ... ICTV Report: Baculoviridae Viralzone: Baculoviridae Index of Viruses - Baculoviridae (2006). In: ICTVdB - The Universal Virus ...

Few viruses like Rift Valley fever virus (RVFV), vesicular stomatitis virus (VSV), and influenza A produce PPP RNA nucleic acid ... The IFIT proteins that are produced in humans and mice are 40%-45% similar. It is thought that the gene encoding IFIT proteins ... So far, four families of this protein have been identified in humans which are IFIT1, IFIT2, IFIT3 and IFIT5 and other variants ... IFIT proteins are suggested to show anti viral activity in two ways; one, by binding specifically to viral nucleic acids and ...

"Systemic therapy of experimental breast cancer metastases by mutant vesicular stomatitis virus in immune-competent mice". ... In a wide range of in vivo cancer models, the HSV1716 virus has induced tumour regression and increased survival times. In 1996 ... an oncolytic herpes virus which is a modified herpes simplex virus, became the first oncolytic virus to be approved for use in ... Vesicular stomatitis virus (VSV) is a rhabdovirus, consisting of 5 genes encoded by a negative sense, single-stranded RNA ...

Merk & Kollegen, boosting its immuno-oncology therapy range including Vesicular Stomatitis Virus and cancer vaccines platforms ... In August 2012, Pradaxa claims filed in the federal court were consolidated in a multi-district litigation in the Southern ... In the same month Boehringer announced a partnership with Topas Therapeutics and their virus-based vectors. In mid-September ... founded in 1985, has had Boehringer Ingelheim as its main sponsor since 1993. In 2011, Ben Venue Laboratories in Bedford, Ohio ...

They have developed a replication-competent vaccine against Lassa virus based on recombinant vesicular stomatitis virus vectors ... The virus was first described in 1969 from a case in the town of Lassa, in Borno State, Nigeria. Lassa fever is relatively ... In cases in which death occurs, this typically occurs within 14 days of onset. About 1% of all Lassa virus infections result in ... Confirmation is by laboratory testing to detect the virus's RNA, antibodies for the virus, or the virus itself in cell culture ...

... a difference also documented for vesicular stomatitis virus (VSV). The replicative capacity of a population ensemble need not ... January 2017). "Deep-Sequence Identification and Role in Virus Replication of a JC Virus Quasispecies in Patients with ... In the first mutant studied, amino acid substitution G46S in the PV polymerase resulted in about four-fold increase in template ... In RNA virus genetics when we speak of "a mutant" the entity we handle is a cloud of mutants in which the specific mutation to ...

The vaccine consists of live-attenuated recombinant vesicular stomatitis virus (VSV) and adenovirus serotype-5 (Ad5) expressing ... An open phase I/II trial in healthy adults in Russia". Hum Vaccin Immunother. 13 (3): 613-620. doi:10.1080/21645515.2016. ... As of 2015[update] the vaccine has been licensed in Russia for emergency use, on the basis of Phase 1 and Phase 2 clinical ... GamEvac-Combi was licensed by the Ministry of Health of the Russian Federation for emergency use in the territory of the ...

... has shown potential virucidal properties against a number of viruses including vesicular stomatitis, vaccinia, human ... Ajoene is also found in garlic extract. Ajoene is most stable and most abundant in macerate of garlic (chopped garlic in edible ... In the infected cell system of a human immunodeficiency virus (HIV), it is shown to block the integrin-dependent processes. ... First, one allicin molecule (1 in the diagram) fragments to form 2-propenesulfenic acid and thioacrolein. These two react in ...

Recombinant vesicular stomatitis virus-Zaire Ebola virus (rVSV-ZEBOV) was created by the Public Health Agency of Canada (PHAC) ... In this way, the properties of dangerous viruses can be studied in a lower risk setting. Pseudotyping allows one to control the ... "Quantification of Lyssavirus-Neutralizing Antibodies Using Vesicular Stomatitis Virus Pseudotype Particles". Viruses. 8 (9): ... A frequently used protein is the glycoprotein G (VSV-G) from the Vesicular stomatitis virus (VSV) which mediates entry via the ...

Kunjin virus and Modoc virus, as well as vesicular stomatitis virus and poliovirus. As lactimidomycin is a natural product ... It has antifungal, antiviral and anti-cancer properties, acting as a direct inhibitor of protein translation in ribosomes. ... Carocci M, Yang PL (April 2016). "Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses". Antiviral ... Antiviral activity is seen against a variety of RNA viruses including flaviviruses such as dengue fever, ...

... along with vesicular stomatitis virus glycoprotein G and baculovirus gp64) belongs to a new class of viral membrane fusion ... Herpesvirus glycoprotein B is a viral glycoprotein that is involved in the viral cell entry of Herpes simplex virus (HSV). ... The crystal structure of herpes simplex virus (HSV) type-1 and Epstein-Barr virus glycoprotein B ectodomains were solved as a ... Finally, domain V acts in conjunction with domain I during protein-lipid interactions. In HSV, neutralizing monoclonal ...

Effects of Defective Interfering Virus-like Particles on the Growth and Population Behavior of Vesicular Stomatitis Virus. ... It was first observed by Preben von Magnus in influenza viruses, after the serial passage of undiluted allantoic fluid in eggs ... Gard, S. (1952). "Studies on the sedimentation of influenza virus". Archiv für die Gesamte Virusforschung. 4 (5): 591-611. doi: ... The von Magnus phenomenon describes the generation of defective interfering particles (DIPs) by viruses. ...

... vesicular stomatitis virus and West Nile virus viruses. Transmission of DHOV by respiratory aerosol has also been observed. No ... ABV was found in the soft-bodied tick genus Ornithodoros in seabird nests in southern Texas, USA, in 1975; it was the first ... as well as the species or strains Araguari virus, Aransas Bay virus (ABV), Bourbon virus, Jos virus (JOSV) and Upolu virus ( ... in the envelope glycoprotein; 96-98% in other proteins), and their antibodies crossreact. Bourbon virus was identified in 2014 ...

"Punctuated equilibrium and positive Darwinian evolution in vesicular stomatitis virus." Proceedings of the National Academy of ... or in the same degree. In the oldest tertiary beds a few living shells may still be found in the midst of a multitude of ... "Speciation in the fossil record." In Erwin, D. H. & Anstey, R. L. (eds). New Approaches to Speciation in the Fossil Record. ... In Schopf, T.J.M. (ed.). Models in Paleobiology. San Francisco, CA: Freeman Cooper. pp. 82-115. Reprinted in Eldredge, N., ed ...

... and has been shown to exhibit antiviral activity against Vesicular stomatitis virus and Encephalomyocarditis virus, as well as ... GBP genes have been universally recognized in mammalian as well as in most other vertebrate genomes. A single cluster of seven ... members of the GBPs gene family are organized in more than one cluster, in this case, 11 (Gbp2b- Gbp110 and 4 genes (Gbp1-Gbp4 ... "Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of ...