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*  ACTC1
Myosin binding increases the flexibility of actin, and cross-linking studies have shown that myosin subfragment-1 binds to ... The E101K missense mutation has been associated with Hypertrophic Cardiomyopathy and Left Ventricular Noncompaction. Another ... Buckingham M, Alonso S, Barton P, Cohen A, Daubas P, Garner I, Robert B, Weydert A (Dec 1986). "Actin and myosin multigene ... Bertrand R, Derancourt J, Kassab R (May 1994). "The covalent maleimidobenzoyl-actin-myosin head complex. Cross-linking of the ...
*  MYL3
Ventricular ELC is part of the myosin molecule and is important in modulating cardiac muscle contraction. Cardiac, ventricular ... Myosin essential light chain (ELC), ventricular/cardiac isoform is a protein that in humans is encoded by the MYL3 gene. This ... "Entrez Gene: MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow". Rayment I, Rypniewski WR, Schmidt-Bäse K, Smith ... Xie B, Huang R, Huang L, Zhou G, Gong Z (October 2003). "The functional domains of human ventricular myosin light chain 1". ...
*  MYL6
Fu ZY, Xie BT, Ma YT, Gong ZX (2006). "Preparation of monoclonal antibodies against human ventricular myosin light chain 1 ( ... Myosin light polypeptide 6 is a protein that in humans is encoded by the MYL6 gene. Myosin is a hexameric ATPase cellular motor ... "Entrez Gene: MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle". Komiyama M, Soldati T, von Arx P, Perriard JC ( ... Lenz S, Lohse P, Seidel U, Arnold HH (Jun 1989). "The alkali light chains of human smooth and nonmuscle myosins are encoded by ...
*  MYL7
ALC-2 is an EF hand protein that binds to the neck region of alpha myosin heavy chain. ALC-2 and the ventricular isoform, VLC-2 ... Svensson C, Morano I, Arner A (November 1997). "In vitro motility assay of atrial and ventricular myosin from pig". Journal of ... Kumar C, Saidapet C, Delaney P, Mendola C, Siddiqui MA (June 1988). "Expression of ventricular-type myosin light chain ... Cummins P (July 1982). "Transitions in human atrial and ventricular myosin light-chain isoenzymes in response to cardiac- ...
*  Actin
Kabaeva Z (2002). Genetic analysis in hypertrophic cardiomyopathy: missense mutations in the ventricular myosin regulatory ... to be a track for cargo transport myosins (nonconventional myosins) such as myosin V and VI. Nonconventional myosins use ATP ... This arrangement allows myosin V to be an effective motor for the export of cargos, and myosin VI to be an effective motor for ... Myosin V walks towards the barbed end of actin filaments, while myosin VI walks toward the pointed end. Most actin filaments ...
*  MYL2
Ventricular myosin light chain-2 (MLC-2v) refers to the ventricular cardiac muscle form of myosin light chain 2 (Myl2). MLC-2v ... Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin ... O'Brien TX, Lee KJ, Chien KR (Jun 1993). "Positional specification of ventricular myosin light chain 2 expression in the ... Cardiac, ventricular RLC is an 18.8 kDa protein composed of 166 amino acids. RLC and the second ventricular light chain, ...
*  PRKCE
Activation of PKCε by εRACK prior to ischemia was also found to phosphorylate Ventricular myosin light chain-2, however the ... England K, Ashford D, Kidd D, Rumsby M (Jun 2002). "PKC epsilon is associated with myosin IIA and actin in fibroblasts". ... Sarcomeric proteins have been identified in PKCε signaling complexes, including actin, cTnT, tropomyosin, desmin, and myosin ... Paul K, Ball NA, Dorn GW, Walsh RA (Nov 1997). "Left ventricular stretch stimulates angiotensin II--mediated ...
*  MYL4
Shift in atrial myosin heavy chains and in ventricular myosin light chains". European Heart Journal. 5 Suppl F: 85-93. doi: ... "Expression of atrial myosin light chains but not alpha-myosin heavy chains is correlated in vivo with increased ventricular ... "Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones". The Journal of ... "The N-terminus of A1-type myosin essential light chains binds actin and modulates myosin motor function". European Journal of ...
*  List of MeSH codes (D12.776)
... atrial myosins MeSH D12.776.210.500.600.470.249.500 - ventricular myosins MeSH D12.776.210.500.600.470.374 - nonmuscle myosin ... atrial myosins MeSH D12.776.220.525.475.475.124.500 - ventricular myosins MeSH D12.776.220.525.475.475.249 - nonmuscle myosin ... myosin type iii MeSH D12.776.220.525.475.681 - myosin type iv MeSH D12.776.220.525.475.750 - myosin type v MeSH D12.776.220.525 ... myosin type i MeSH D12.776.210.500.600.470 - myosin type ii MeSH D12.776.210.500.600.470.249 - cardiac myosins MeSH D12.776. ...
*  MYH6
This isoform is distinct from the ventricular/slow myosin heavy chain isoform, MYH7, referred to as MHC-β. MHC-α isoform is ... The proposed mechanism for this is the expression of a more normalized ratio of α-myosin chain to β-myosin chain proteins. This ... It is the enzymatic activity of the ATPase in the myosin head that cyclically hydrolyzes ATP, fueling the myosin power stroke. ... "Complete sequence of human cardiac alpha-myosin heavy chain gene and amino acid comparison to other myosins based on structural ...
*  Myosin binding protein C, cardiac
"Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening". Circulation Research. 94 (9): ... "Dissecting the N-terminal myosin binding site of human cardiac myosin-binding protein C. Structure and myosin binding of domain ... cMyBP-C regulates the positioning of myosin and actin for interaction and acts as a tether to the myosin S1 heads, limiting ... cMyBP-C is a myosin-associated protein that binds at 43 nm intervals along the myosin thick filament backbone, stretching for ...
*  List of MeSH codes (D05)
... cardiac myosins MeSH D05.750.078.730.475.475.124.249 --- atrial myosins MeSH D05.750.078.730.475.475.124.500 --- ventricular ... myosin type iii MeSH D05.750.078.730.475.681 --- myosin type iv MeSH D05.750.078.730.475.750 --- myosin type v MeSH D05.750. ... myosin subfragments MeSH D05.750.078.730.475.470 --- myosin type i MeSH D05.750.078.730.475.475 --- myosin type ii MeSH D05.750 ... myosins MeSH D05.750.078.730.475.100 --- myosin heavy chains MeSH D05.750.078.730.475.200 --- myosin light chains MeSH D05.750. ...
*  ITGA7
... inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non- ... Additionally, in patients with severe congenital fiber type disproportion and left ventricular non-compaction cardiomyopathy, a ...
*  List of MeSH codes (D08)
... ventricular myosins MeSH D08.811.277.040.025.525.750.374 --- nonmuscle myosin type iia MeSH D08.811.277.040.025.525.750.500 ... myosin type iii MeSH D08.811.277.040.025.525.843 --- myosin type iv MeSH D08.811.277.040.025.525.875 --- myosin type v MeSH ... myosins MeSH D08.811.277.040.025.525.500 --- myosin type i MeSH D08.811.277.040.025.525.750 --- myosin type ii MeSH D08.811. ... nonmuscle myosin type iib MeSH D08.811.277.040.025.525.750.750 --- skeletal muscle myosins MeSH D08.811.277.040.025.525.750.875 ...
*  Omecamtiv mecarbil
This enhances effective myosin cross-bridge formation and duration, while the velocity of contraction remains the same. It also ... It is being studied for a potential role in the treatment of left ventricular systolic heart failure. Systolic heart failure ... Chemical energy in the form of ATP is converted into mechanical energy which allows myosin to strongly bind to actin and ... Malik F, Teerlink J, Escandon R, Clake C, Wolff A (2006). "The Selective Cardiac Myosin Activator, CK-1827452, a Calcium- ...
*  MYBPC1
... missense mutation in the myosin binding protein-C gene is responsible for hypertrophic cardiomyopathy with left ventricular ... 2006). "Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere ... "Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod". Biochem J. ... Myosin-binding protein C, slow-type is a protein that in humans is encoded by the MYBPC1 gene. GRCh38: Ensembl release 89: ...
*  TNNT2
The N-terminal region of TnT that strongly binds actin most likely moves with Tm and actin during strong myosin crossbridge ... Solaro RJ, Lee JA, Kentish JC, Allen DG (Oct 1988). "Effects of acidosis on ventricular muscle from adult and neonatal rats". ... Advancement to dilated cardiomyopathy may be more rapid in patients with TNNT2 mutations than in those with myosin heavy chain ... Phosphorylation of cTnT at Ser278 and Thr287 by ROCK-II was shown to decrease myosin ATPase activity and myofilament force ...
*  Autoregulation
Via the Anrep effect, positive inotropy occurs secondary to increased ventricular pressure. This is in contrast to heterometric ... which results from a more favorable positioning of actin and myosin filaments in cardiomyocytes as a result of changing fiber ...
*  Celivarone
Mutations cause many arrhythmic conditions, including atrial fibrillation (AF), atrial flutter (AFl), and ventricular ... more actin-myosin interactions and causing an increased contractility, respectively. ... as well as ischemic and reperfusion ventricular fibrillation. Since it affects multiple ion channels, it also shows promise in ... Underlie Catecholaminergic Polymorphic Ventricular Tachycardia". Circulation. 103 (2): 196-200. doi:10.1161/01.CIR.103.2.196. ...
*  Pathophysiology of heart failure
... early-to-atrial left ventricular filling ratio), the E (early left ventricular filling) deceleration time, and the isovolumic ... This is due to reduced ability to cross-link actin and myosin filaments in over-stretched heart muscle. A reduced stroke volume ... The failure of ventricular relaxation also results in elevated end-diastolic pressures, and the end result is identical to the ... The increase in ventricular volume also causes a reduction in stroke volume due to mechanical and inefficient contraction of ...
*  Intermediate filament
Arrhythmogenic right ventricular cardiomyopathy (ARVC), mutations in the DES gene. Epidermolysis bullosa simplex; K5 or K14 ... Plectin links vimentin to other vimentin fibers, as well as to microfilaments, microtubules, and myosin II. Kinesin is being ... and wider myosin filaments found in muscle cells, the diameter of Intermediate filaments is now commonly compared to actin ... "De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy". Hum. Mol. Genet. 19 (23): ...
*  Myotonin-protein kinase
Myosin phosphatase is an enzyme that plays a role in muscle tensing (contraction) and relaxation. Dystrophia myotonica protein ... This kinase exists both as a membrane-associated and as a soluble form in human left ventricular samples. The different C ... For example, myotonic dystrophy protein kinase has been shown to turn off (inhibit) part of a muscle protein called myosin ... Among the substrates for DMPK proposed by in vitro studies are phospholemman, the dihydropyridine receptor, and the myosin ...
*  HIV associated cardiomyopathy
... increases left ventricular wall thickness, and reduces peak left ventricular wall stress. Perhaps this is because ... anti-α-myosin autoantibodies) than HIV-infected patients with healthy hearts and HIV-negative controls. In addition, patients ... Left ventricular structure and function in children infected with human immunodeficiency virus. The prospective P2C2 HIV ... Many patients with HIV have nutritional deficiencies which have been linked to left ventricular dysfunction. HIV-infected ...
*  Congenital heart defect
Ventricular septal defects are collectively the most common type of CHD, although approximately 30% of adults have a type of ... Mutations of a heart muscle protein, α-myosin heavy chain (MYH6) are associated with atrial septal defects. Several proteins ... It is also involved in the development of the ventricular wall and the connection of the outflow tract to the great vessels. ... "Ventricular Septal Defect". eMedicine Health. Archived from the original on 18 July 2010. Retrieved 30 July 2010. "Circulatory ...
*  Dilated cardiomyopathy
Cardiac Myosin Binding Protein C (MYBPC3), Myosin Heavy Chain 7 (MYH7), Cardiac Troponin T 2 (TNNT2), and Cardiac Troponin I ( ... In addition, the ventricular walls maintain the same thickness, characteristic of pathophysiological cardiac dilation. As the ... Echocardiogram shows left ventricular dilatation with normal or thinned walls and reduced ejection fraction. Cardiac ... The progression of heart failure is associated with left ventricular remodeling, which manifests as gradual increases in left ...
*  Frank-Starling law
Premature ventricular contraction causes early emptying of the left ventricle (LV) into the aorta. Since the next ventricular ... causing a greater number of actin-myosin cross-bridges to form within the muscle fibers. Specifically, the sensitivity of ... The mechanism is of functional importance because it serves to adapt left ventricular output to right ventricular output. If ... Due to the Frank-Starling mechanism, the next ventricular contraction is more forceful, leading to the ejection of the larger ...
*  Systole
The sharp decrease in ventricular pressure that occurs during ventricular diastole allows the atrioventricular valves (or ... Subsequently, a rise in intracellular calcium triggers the interaction of actin and myosin in the presence of ATP which ... Atrial contraction confers a minor-fraction addition to ventricular filling, but becomes significant in left ventricular ... it occurs during ventricular diastole. Ventricular systole is the origin of the pulse. The pulmonary (or pulmonic) valve in the ...