2002). "Delayed Up-regulation of Vascular Endothelial Growth Factor and flk-1 after Global Cerebral Ischemia in Mongolian ... Tip cells have receptors and ligands via which they respond to local neuroangiogenic factors. There are many neuroangiogenic ... Neuronal growth cones are situated on the tips of nerve cells and are responsive to different factors, both positive and ... The nervous and blood vessel systems share guidance cues and cell-surface receptors allowing for this synchronised growth. The ...
"Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro ... Xin X, Yang S, Kowalski J, Gerritsen ME (March 1999). "Peroxisome proliferator-activated receptor gamma ligands are potent ... February 1996). "The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the ... 1. Discovery of novel oxyiminoacetic acid derivatives". Chemical & Pharmaceutical Bulletin. 50 (10): 1349-1357. doi:10.1248/cpb ...
These proteins include vascular endothelial growth factor (VEGF), Hypoxia-inducible factor-1a, Platelet-derived growth factor, ... Some theories suggest a genetic cause while other literature supports the involvement of hormone and growth factor receptors, ... In addition, vascular factors promoting angiogenesis have been shown to further promote growth of these breast masses. ... Their growth can be slow, rapid, or demonstrate alternating growth patterns. A notable feature, however, is that their growth ...
... is also required for induction of vascular endothelial growth factor (VEGF) and nitric oxide synthase (NOS). Both are ... Cancerous cells overexpress a number of proteins, including growth factor receptors, such as EGFR, or signal transduction ... "Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors ... Hsp90 stabilizes various growth factor receptors and some signaling molecules including PI3K and AKT proteins. Hence inhibition ...
... vascular endothelial growth factor and matrix metalloproteinase-2 genes and blocking transcriptional survival signals. p53 ... Gendicine enters the tumour cells by way of receptor-mediated endocytosis and begins to over-express genes coding for the p53 ... which increases the expression of tumour suppressor genes and immune response factors (such as the ability of natural killer ( ... 22 (1): 3-4. doi:10.1038/nbt0104-3. PMC 7097065. PMID 14704685. Peng, Zhaohui (1 May 2004). "The Genesis of Gendicine: The ...
... endothelial buds form by an extrusion-like process which is prompted by the expression of vascular endothelial growth factor ( ... effects on genes which deal with endothelial response to turbulent flow Shear stress induces phosphorylation of VEGF receptors ... The growth of tumours often results in reactivation of blood vessel growth and vascular remodelling in order to perfuse the new ... transforming growth factor beta (TGFβ), and Kruppel-like factor 2 (Klf-2) are induced by shear stress and may have up- ...
It has been shown that osteoblasts that originate from vascular endothelial growth factor (VEGF) signaling play a crucial role ... and growth factors. Integrins, a type of transmembrane receptor protein, have been shown to be important for angiogenesis. When ... Targeting integrin αvβ5 was shown to have a negative effect on vascular endothelial growth factor (VEGF)-dependent angiogenesis ... Growth factors, such as bone morphogenic proteins (BMPs), are important in inducing the differentiation of MSCs during bone ...
... and growth factors that stimulate modified lipoprotein uptake and vascular smooth muscle cell (VSMC) proliferation. VSMC can ... These scavenger receptors act as "Pattern recognition receptors" (PRR's) on macrophages and are responsible for recognizing and ... Monocytes are then able to penetrate the arterial wall as a result of impaired endothelial integrity which increases ... Free cholesterol can then be secreted from the macrophage by the efflux to ApoA1 and ApoE discs via the ABCA1 receptor. This ...
Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, and Hedgehog Signaling". Journal of Medicinal Chemistry. ... It stops fungal growth by affecting the cell membrane or affecting their metabolism. Itraconazole was patented in 1978 and ... Aftab BT, Dobromilskaya I, Liu JO, Rudin CM (2011). "Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung ... Aftab BT, Dobromilskaya I, Liu JO, Rudin CM (2011). "Itraconazole Inhibits Angiogenesis and Tumor Growth in Non-Small Cell Lung ...
These include all receptors for platelet-derived growth factor (PDGF-Rs) and vascular endothelial growth factor receptors ( ... The concept was of an ATP mimic that would compete with ATP for binding to the catalytic site of receptor tyrosine kinases. ... It is a small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment ... These include: RET CD114 CD135 The fact that sunitinib targets many different receptors, leads to many of its side effects such ...
... vascular endothelial growth factor, Cyclin D1, phosphofructokinase-muscle isoform, nuclear factor of activated T-cell, Cyclin ... "Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases". The ... Bagheri-Yarmand R, Vadlamudi RK, Wang RA, Mendelsohn J, Kumar R (December 2000). "Vascular endothelial growth factor up- ... basic fibroblast growth factor, platelet-derived growth factor, estrogen, lysophosphatidic acid, phosphoinositides, ETK, AKT, ...
... the IGF1 receptor, the MuSK protein receptor, the Vascular Endothelial Growth Factor (or VEGF) receptor, etc. Currently, there ... Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or ... There is one other BDNF receptor besides TrkB, called the "LNGFR" (for "low-affinity nerve growth factor receptor"). Unlike ... "trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor". Cell ...
"Vascular endothelial growth factor and fibroblast growth factor 5 are colocalized in vascular and avascular epiretinal ... "Fibroblast growth factor signalling in the hair growth cycle: expression of the fibroblast growth factor receptor and ligand ... "Fibroblast growth factor 5 proto-oncogene is expressed in normal human fibroblasts and induced by serum growth factors". ... Clements DA, Wang JK, Dionne CA, Goldfarb M (May 1993). "Activation of fibroblast growth factor (FGF) receptors by recombinant ...
Vascular endothelial growth factor A (VEGF-A). The role of autocrine transforming growth factor beta 1(TGF-β1) signaling on ... Others are MMTV-PyMT; uPA-/- and MMTV-PyMT; MEKK1-/-. The MMTV-LTR can also be used to promote receptor tyrosine-protein kinase ... The RMF/EG fibroblast must then be irradiated to allow the expression of key proteins and growth factors. After 4 weeks of ... Siegel, P. M.; Shu, W; Cardiff, R. D.; Muller, W. J.; Massagué, J (2003). "Transforming growth factor beta signaling impairs ...
... an antagonist of vascular endothelial growth factor receptor 2 (VEGFR-2), which has entered Phase II clinical trials ... ISBN 978-1-59745-187-1. PMID 17041261. Wojcik J, Hantschel O, Grebien F, Kaupe I, Bennett KL, Barkinge J, Jones RB, Koide A, ...
"16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells". ... Epidermal growth factor receptor, FRS2, Grb2, HRAS, ITSN1, MUC1, NCK1, PLCG1, PTPN11, SH3KBP1, and SHC1. and Son of Sevenless ... and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells". Biochemical and Biophysical Research Communications ... "Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation ...
... vascular endothelial growth factor [VEGF] and fibroblast growth factor [FGF]) 3. The classic representation of α-granules as ... An electron-dense granule defined by the presence of Toll-like receptor 9 (TLR9) and protein disulfide isomerase (PDI), termed ... von Willebrand factor [VWF] and factor V), inflammation (for example, chemokines such as CXCL1 and interleukin-8), and wound ... They contain mainly proteins, both membrane-associated receptors (for example, αIIbβ3 and P-selectin) and soluble cargo (for ...
This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor ... "Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells". ... insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a ... insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a ...
... inhibits vascular endothelial growth factor angiogenic signaling by disrupting the formation of a receptor complex". ... vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and transforming growth factor-β (TGF-β). These ... Hugo H. Marti, "Vascular Endothelial Growth Factor", Madame Curie Bioscience Database, Landes Bioscience, retrieved January 25 ... Rini BI (February 2007). "Vascular endothelial growth factor-targeted therapy in renal cell carcinoma: current status and ...
... suppresses the angiogenesis and melanoma growth through inhibition of vascular endothelial growth factor (VEGF) via PKCα ... December 2013). "G-protein coupled receptor 56 promotes myoblast fusion through serum response factor- and nuclear factor of ... Luo R, Jeong SJ, Jin Z, Strokes N, Li S, Piao X (August 2011). "G protein-coupled receptor 56 and collagen III, a receptor- ... "The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity". The Journal of ...
Anti-vascular endothelial growth factor therapy, also known as anti-VEGF (/vɛdʒˈɛf/) therapy or medication, is the use of ... some of these therapies target VEGF receptors rather than the VEGFs). Both antibody-based compounds and the first three orally ... Braithwaite T, Nanji AA, Lindsley K, Greenberg PB (May 2014). "Anti-vascular endothelial growth factor for macular oedema ... Virgili G, Parravano M, Evans JR, Gordon I, Lucenteforte E (October 2018). "Anti-vascular endothelial growth factor for ...
... scutellarin inhibits hypoxia-induced and moderately high glucose-induced proliferation and vascular endothelial growth factor ( ... One mechanism of scutellarin's antitumor action is to bind to TNF receptor II (TNFR2) in tumor-associated CD4+Foxp3+ regulatory ... agent-induced angiogenic effects in human retinal endothelial cells through reactive oxygen species/hypoxia-inducible factor-1α ... vascular endothelial growth factor pathway". Journal of Cardiovascular Pharmacology. 64 (3): 218-227. doi:10.1097/FJC. ...
The SHC proteins are regulated by tyrosine phosphorylation and are part of the growth factor and stress-induced ERK activation ... The SHC and its adaptor proteins transmit signaling of the cell surface receptors such as EGFR, erbV-2 and insulin receptors. ... p66SHC can be altered by changes in the glucose metabolism and vascular senescence. When protein kinase C is induced by ... SHC1 has been found to act in signaling information after epidermal growth factor (EGF) stimulation. Activated tyrosine kinase ...
"Development of human antibodies to human vascular endothelial growth factor -C (VEGF-C) and -D (VEGF-D)". "Obtaining Antibodies ... Antigen PA63 Discovery of Therapeutic Antibodies to Difficult Membrane Proteins Therapeutic antibody discovery Cell-receptor ... at Antibody Solutions using the OmniAb Platform Development of human antibodies to human vascular endothelial growth factor -C ... Comparison of the Guava Easy CD4 and the BD Biosciences MultiTest Assays for the determination of CD4 T-cell counts in HIV-1- ...
A lack of pericytes also causes an upregulation of vascular endothelial growth factor (VEGF), leading to vascular leakage and ... Platelet-derived growth factor B (PDGFB) is released from endothelial cells in brain vasculature and binds to the receptor ... vascular endothelial growth factor (VEGF), and type IV collagenase, the former two localized to both endothelium and pericytes ... "Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host ...
Loss of pericyte growth factor (PDGFB) and its receptor on endothelial cells are molecular-level changes that can account for ... Many tumors are characterized by high expression of vascular endothelial growth factor (VEGF), which is a strong vasodilator. ... These tumor-associated endothelial cells can also release factors and supply nutrients that promote the growth of the primary ... These tumor-associated endothelial cells have been found to over-express the endothelin B receptor, which suppresses T-cell ...
Bevacizumab is a monoclonal antibody that targets Vascular Endothelial Growth Factor (VEGF) in the circulation and functions as ... with epidermal growth factor receptor (EGFR) exon 20 insertion mutations, as detected by an FDA-approved test, whose disease ... which is a monoclonal antibody medication targeted against the vascular endothelial growth factor (VEGF). This is based on an ... mutations within epidermal growth factor (EGFR) and anaplastic lymphoma kinase. Also, a number of additional genetic markers ...
The enhanced growth of these cells is believed to be due to the secretion of angiogenic factors, thus inducing ... It infects endothelial cells and can infect erythrocytes by binding and entering with a large vacuole. Once inside, they begin ... A major role in B. quintana infection is its lipopolysaccharide covering which is an antagonist of the toll-like receptor 4. ... B. quintana also induces lesions seen in bacillary angiomatosis that protrude into vascular lumina, often occluding blood flow ...
"Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C". J. ... share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like ... Makinde T, Murphy RF, Agrawal DK (2007). "Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in ... All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein ...
... a single intramyocardial injection of human vascular endothelial growth factor A mRNA (VEGF-A modRNA), modified to escape the ... The researchers discovered that GCSF-mimicking antibody can activate a growth-stimulating receptor on marrow cells in a way ... with or without 3 growth factors (transforming growth factor-β (TGF-β), basic fibroblast growth factor (bFGF), and leukemia ... of fibroblast growth factor-2 (FGF-2) and epidermal growth factor. Unlike current protocols for deriving hepatocytes from human ...