*Catenin

Yi ZY, Feng LJ, Xiang Z, Yao H (2011). "Vascular endothelial growth factor receptor-1 activation mediates epithelial to ... conditional inactivation of the β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular ... to specifically have vascular endothelium cells deficient in β-catenin showed disrupted adhesion between vascular endothelial ... homeostasis and growth, also make it susceptible to alterations that can lead to abnormal cell behavior and growth. Any changes ...

*VEGFR1

... vascular endothelial growth factor/vascular permeability factor receptor)". Seki T, Hosaka K, Fischer C, Lim S, Andersson P, ... Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene. Oncogene FLT belongs to ... Shibuya M (2007). "Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis". ... FLT1 has been shown to interact with PLCG1 and vascular endothelial growth factor B (VEGF-B). VEGF receptors GRCh38: Ensembl ...

*FLT4

"Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 ( ... This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be ... Petrova TV, Makinen T, Alitalo K (November 1999). "Signaling via vascular endothelial growth factor receptors". Experimental ... "Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4". ...

*FER1L3

"Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function". J Biol Chem. 282 (42): 30745-53. doi ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and ... Britton S, Freeman T, Vafiadaki E, Keers S, Harrison R, Bushby K, Bashir R (Nov 2000). "The third human FER-1-like protein is ... 12 (1): 1-11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). " ...

*Neuropilin 2

Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000). "Neuropilin-2 is a receptor for the vascular endothelial growth factor ... Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (2001). "Vascular endothelial growth factor receptor-1 and neuropilin-2 form ... 2002). "Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma". ... "Vascular endothelial growth factor (VEGF) and its receptors". FASEB J. 13 (1): 9-22. PMID 9872925. Kolodkin AL, Levengood DV, ...

*Asif Ahmed (scientist)

Ahmad, S; Ahmed, A (2004). "Elevated Placental Soluble Vascular Endothelial Growth Factor Receptor-1 Inhibits Angiogenesis in ... He has a longstanding interest in the mechanisms of vascular endothelial growth factor signalling, endothelial cell protection ... Ahmed's laboratory was amongst the first to signal the importance of vascular growth factors in pregnancy and pioneered the ... the natural anti-VEGF factor in circulation, is increasingly recognized as a major factor responsible for the clinical signs of ...

*TMCO4

"FLT1 - Vascular endothelial growth factor receptor 1 precursor - Homo sapiens (Human) - FLT1 gene & protein". www.uniprot.org. ... FLT1 is a VEGF receptor. VEGF is known to play a significant role in cancer development. Other proteins that TMCO4 has been ... Expression of TMCO4 is predicted to be controlled by many transcription factors. TMCO4 is not currently directly linked to any ... However, interacting with a VEGF receptor may be indicative of a possible role in cancer. "TMCO4 transmembrane and coiled-coil ...

*PTTG1

"Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors". The ... as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is ... Chien W, Pei L (Jun 2000). "A novel binding factor facilitates nuclear translocation and transcriptional activation function of ... Chien W, Pei L (Jun 2000). "A novel binding factor facilitates nuclear translocation and transcriptional activation function of ...

*Annexin A5

"Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1". Biochemical and ... Platelets also expose PS and PE on their surface when activated, which serves as binding site for various coagulation factors. ... Annexin A5 has been shown to interact with Kinase insert domain receptor and Integrin, beta 5. GRCh38: Ensembl release 89: ... "Cloning and expression of cDNA for human vascular anticoagulant, a Ca2+-dependent phospholipid-binding protein". European ...

*GTF2IRD1

2005). "Vascular endothelial growth factor receptor-2: counter-regulation by the transcription factors, TFII-I and TFII-IRD1". ... Vullhorst D, Buonanno A (2003). "Characterization of general transcription factor 3, a transcription factor involved in slow ... General transcription factor II-I repeat domain-containing protein 1 is a protein that in humans is encoded by the GTF2IRD1 ... 2000). "A transcription factor involved in skeletal muscle gene expression is deleted in patients with Williams syndrome". Eur ...

*Ischemia-reperfusion injury of the appendicular musculoskeletal system

23(10): p. 1305-19 Kapitsinou, P.P., et al., Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury. J ... Tan, X., et al., Angiopoietin-2 impairs collateral artery growth associated with the suppression of the infiltration of ... Ischemia-reperfusion (IR) tissue injury is the resultant pathology from a combination of factors, including tissue hypoxia, ... the extremity is exposed to an enormous flux in vascular perfusion during a critical period of tissue repair and regeneration. ...

*Vandetanib

... mainly the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor (EGFR), and the RET- ... Vandetanib is an inhibitor of vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and RET tyrosine ... It acts as a kinase inhibitor of a number of cell receptors, ... Common (present in between 1% and 10% of people) adverse ... 0: 1-11. doi:10.1515/dmdi-2013-0062. PMC 4407685 . PMID 24643910. Khurana V, Minocha M, Pal D, Mitra AK (May 2014). "Inhibition ...

*Semaxanib

... receptor tyrosine kinase. It targets the VEGF pathway, and both in vivo and in vitro studies have demonstrated antiangiogenic ... Semaxanib is a potent and selective synthetic inhibitor of the Flk-1/KDR vascular endothelial growth factor (VEGF) ...

*BRCA1

"Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription ... The target tissue may have receptors for the pathogen, may become selectively exposed to an inflammatory process or to a ... Neish AS, Anderson SF, Schlegel BP, Wei W, Parvin JD (February 1998). "Factors associated with the mammalian RNA polymerase II ... Breast cancers can be classified based on receptor status or histology, with triple-negative breast cancer (15%-25% of breast ...

*Parinari campestris

... shown to inhibit the interaction between Vascular endothelial growth factor A and Vascular endothelial growth factor receptor 1 ... of Plant Derivatives for the Inhibition of VEGF Family Members Interaction with Vascular Endothelial Growth Factor Receptor 1 ... 1-409. Winer, Lise (2009). Dictionary of the English/Creole of Trinidad & Tobago: On Historical Principles. Montreal: McGill- ...

*Neuropilin 1

NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240 ... Whitaker GB, Limberg BJ, Rosenbaum JS (July 2001). "Vascular endothelial growth factor receptor-2 and neuropilin-1 form a ... "Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma". Cancer. 94 ... "Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma". Genes, Chromosomes & Cancer. 33 (3): ...

*BRCA1 - Wikipédia, a enciclopédia livre

Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription ... positive regulation of vascular endothelial growth factor production. • DNA damage response, signal transduction by p53 class ... O AhR (Aromatic hydrocarbon Receptor) é um outro importante receptor nuclear que atua na regulação da expressão de BRCA1 ... androgen receptor binding. • RNA binding. • ubiquitin protein ligase binding. • transcription regulatory region DNA binding. • ...

*BRCA1

"Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription ... positive regulation of vascular endothelial growth factor production. • DNA damage response, signal transduction by p53 class ... androgen receptor binding. • RNA binding. • ubiquitin protein ligase binding. • transcription regulatory region DNA binding. • ... androgen receptor signaling pathway. • negative regulation of centriole replication. • postreplication repair. • Lipid ...

*ABL2

... ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and ... 1998). "Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor". ... 1998). "Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor". J. Biol. Chem. 273 (27 ... 2002). "The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at ...

*LPAR3

2003). "Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in ... "Lysophospholipid Receptors: LPA3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... This receptor couples predominantly to G(q/11) alpha proteins. Lysophospholipid receptor GRCh38: Ensembl release 89: ... Lysophosphatidic acid receptor 3 also known as LPA3 is a protein that in humans is encoded by the LPAR3 gene. LPA3 is a G ...

*EPAS1

... a transcription factor selectively expressed in endothelial cells". Genes & Development. 11 (1): 72-82. doi:10.1101/gad.11.1.72 ... similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular ... EPAS1 has been shown to interact with aryl hydrocarbon receptor nuclear translocator and ARNTL. GRCh38: Ensembl release 89: ... It is a type of hypoxia-inducible factor, a group of transcription factors involved in body response to oxygen level. The gene ...

*Gold nanoparticles in chemotherapy

... and fibroblast growth factor (FGF) Examples of inhibitors include Vascular Endothelial Growth Factor Receptor 1, etc. Tumor ... with prime examples being the vascular endothelial growth factor 165 (VEGF165) and the basic fibroblast growth factor (bFGF) - ... Examples of promoters include Vascular Endothelial Growth Factor (VEGF) ... al found that the malignant cells that had undergone incubation in AuNPs conjugated with anti-epithelial growth factor receptor ...

*PEDF

... factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1". The ... "Down-regulation of vascular endothelial growth factor and up-regulation of pigment epithelium-derived factor: a possible ... "Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor are related to diabetic macular ... "Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF ...

*Soluble fms-like tyrosine kinase-1

Kendall R, Thomas K. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor ... vascular endothelial growth factor) and PlGF (placental growth factor). sFlt-1 thereby blunts the beneficial effects of these ... which is produced by a variety of tissues.These proteins act as a receptor of vascular endothelial growth factor (VEGF), a ... potent angiogenic growth factor. (Another VEGF receptor is KDR). sFlt-1 (soluble fms-like tyrosine kinase-1 - also known as ...

*Targeted therapy

2010). "Safety and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor YN968D1 in ... receptor expressed in some types of breast cancer Alemtuzumab Cetuximab target the epidermal growth factor receptor (EGFR). It ... Gefitinib (Iressa, also known as ZD1839), targets the epidermal growth factor receptor (EGFR) tyrosine kinase and is approved ... Erlotinib (marketed as Tarceva). Erlotinib inhibits epidermal growth factor receptor, and works through a similar mechanism as ...

*SHC2

2001). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in ... forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. England. 347 (Pt 2 ... Liu HY; Meakin SO (2002). "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases". J. Biol. Chem. 277 (29): ... SHC2 has been shown to interact with Kinase insert domain receptor. GRCh38: Ensembl release 89: ENSG00000129946 - Ensembl, May ...

*Autocrine signalling

Another agent involved in autocrine cancer signaling is vascular endothelial growth factor (VEGF). VEGF, produced by carcinoma ... and FGF receptors in NSCLC cell lines, and found that FGF2, FGF9 and their receptors encompass a growth factor autocrine loop ... Weigand, Melanie; Hantel, Pia; Kreienberg, Rolf; Waltenberger, Johannes (2005). "Autocrine vascular endothelial growth factor ... For example, despite widespread expression of epidermal growth factor receptors (EGFRs) and EGF family ligands in non-small- ...

*Endothelial stem cell

... vascular endothelial growth factors VEGF-C and VEGF-D function as ligands for the vascular endothelial growth factor receptor 3 ... endothelial progenitor cells, and then into mature endothelium. It is well established that insulin-like growth factor (IGF) ... "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor". EMBO Journal. ... Piecewicz SM, Pandey A, Roy B, Xiang SH, Zetter BR, Sengupta S (2012). "Insulin-like growth factors promote vasculogenesis in ...