... screen for proteins involved vesicle-mediated vacuolar protein sorting (hence Vps). A number of proteins containing a ... Vps34 has been shown to interact with Vps15 (PIK3R4, p150), a protein kinase. Vps15 can activate the lipid kinase activity of ... Vps15 has a myristoylation tag that associates the complex with the membrane. The Vps34/15 complex also can interact with Rab7 ... Class III PI 3-kinase is a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain ...