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*  Pertussis toxin
It has also become an essential component of new acellular vaccines. PT has been shown to affect the innate immune response. It ... Cherry JD (March 2007). "Historical Perspective on Pertussis and Use of Vaccines to Prevent It". Microbe Magazine. Parton R ( ...
*  Tamas Bartfai
With Per Askelöf and Stefan B. Svenson, Bartfai created the first acellular pertussis (whooping cough) vaccine that is part of ... This model is now used to produce other safe acellular vaccines. They also showed that 'toxoidation' of whole bacteria with ... ethical committees for vaccine programmes; bacterial vaccine development and distribution efforts; and landmine issues and the ... who had the disease and or were vaccinated with the old whole-cell vaccine, and attached these antigenic peptides onto the ...
*  Pertussis vaccine
... whole-cell vaccines and acellular vaccines. The whole-cell vaccine is about 78% effective while the acellular vaccine is 71-85 ... Only the acellular vaccine is used in the US. As of 2009 there were four acellular TDaP/Tdap vaccines licensed for use in USA: ... The vaccine is only available in combination with other vaccines. The acellular vaccines are more commonly used in the ... pertussis vaccine, however the efficacy of the acellular vaccine declines faster than the whole-cell vaccine. Between 10 and 50 ...
*  Australian Vaccination-Skeptics Network
1996). "A Controlled Trial of Two Acellular Vaccines and One Whole-Cell Vaccine against Pertussis". The New England Journal of ... Juretzko, P; von Kries R; Wirsing von Konig CH; Weil J; Giani G. (2002). "Effectiveness of Acellular Pertussis Vaccine assessed ... "The vaccine manufacturers know they've got to through this process and pass all the tests to demonstrate that the vaccine is ... Critics point out that evidence has shown that the acellular vaccine is 84% efficacious, and prevents 99.8% of infant hospital ...
*  Anthrax
Currently administered human anthrax vaccines include acellular (United States) and live spore (Russia) varieties. All ... New second-generation vaccines currently being researched include recombinant live vaccines and recombinant subunit vaccines. ... The human vaccine for anthrax became available in 1954. This was a cell-free vaccine instead of the live-cell Pasteur-style ... "Anthrax and Anthrax Vaccine - Epidemiology and Prevention of Vaccine-Preventable Diseases Archived 24 August 2012 at the ...
*  Pertactin
"Acellular pertussis vaccines and the role of pertactin and fimbriae". Expert Rev Vaccines. 6 (1): 47-56. doi:10.1586/14760584.6 ... Bordetella pertussis and is used for the vaccine production as one of the important components of acellular pertussis vaccine. ...
*  Rino Rappuoli
... and pneumococcus vaccines; an acellular pertussis vaccine containing a genetically detoxified pertussis toxin; the first ... Rappuoli joined Chiron as head of European vaccines research in 1992 with the acquisition of Italian vaccines company Sclavo ... Rappuoli, was previously the Global Head of Vaccines Research for Novartis Vaccines & Diagnostics (Siena, Italy) Since 2015, Dr ... Rappuoli, Rino (2001). "Reverse vaccinology, a genome-based approach to vaccine development". Vaccine. 19 (17-19): 2688-2691. ...
*  Exotoxin
... diphtheria and monocomponent acellular pertussis (TdaP) vaccine in comparison to a tetanus and diphtheria (Td) vaccine when ... A widely used toxoid vaccine is the DPT vaccine, which is usually administered in multiple doses throughout childhood with ... and Acellular Pertussis Vaccine, Adsorbed (Boostrix®)". BioDrugs. 27 (1): 75-81. doi:10.1007/s40259-012-0009-y. ISSN 1173-8804 ... doi:10.1016/j.vaccine.2012.06.073. Kreitman, R. J. (October 1999). "Immunotoxins in cancer therapy". Current Opinion in ...
*  DPT vaccine
This is in contrast to whole-cell, inactivated DTP (aka DTwP). The acellular vaccine uses selected antigens of the pertussis ... The World Health Organization recommends a pentavalent vaccine, combining the DTP vaccine with vaccines against Haemophilus ... On June 10, 2005, a tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) was licensed in the United ... "Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine from the ...
*  Antitoxin
Tetanus toxoid is commonly given in combination with diphtheria toxoid acellular pertussis vaccine. The vaccine provides a ...
*  Anthrax vaccines
Currently administered human anthrax vaccines include acellular (USA, UK) and live spore (Russia) varieties. All currently used ... New third-generation vaccines being researched include recombinant live vaccines and recombinant sub-unit vaccines. In the ... These vaccines may be given by aerosol, scarification, or subcutaneous injection. A Georgian/Russian live anthrax spore vaccine ... This was a cell-free vaccine in distinction to the live-cell Pasteur-style vaccine previously used for veterinary purposes. It ...
*  Pertussis
The vaccine saved an estimated half a million lives in 2002. The multicomponent acellular pertussis vaccine is 71-85% effective ... Both WHO and the CDC found that the acellular pertussis vaccines were effective at prevention of the disease, but had a limited ... The pertussis vaccine became available in the 1940s. Play media Play media The classic symptoms of pertussis are a paroxysmal ... The vaccine becomes less effective over time, with additional doses often recommended for older children and adults. ...
*  National Vaccine Information Center
The CDC now recommends the newer acellular pertussis vaccines (DTaP and Tdap), and whole cell pertussis vaccines are no longer ... Halperin, S; Scheifele, DE; MacDonald, NE (1992). "Acellular versus whole-cell pertussis vaccines". The Canadian Journal of ... "Pertussis Vaccination: Use of Acellular Pertussis Vaccines Among Infants and Young Children Recommendations of the Advisory ... 2011 Official website National Childhood Vaccine Injury Act: Vaccine Injury Table, U.S. Department of Health and Human Services ...
*  DTPa
... is the acronym for the triple antigen, combined diphtheria - tetanus - acellular pertussis vaccine administered to ... tetanus and acellular pertussis-containing vaccines. The acronym dTpa is used for formulations that contain substantially ... DTPa Child and Adult formulations of the vaccine. ... dTpa vaccines are usually used in adolescents and adults." ...
*  Adaptive immune system
Most viral vaccines are based on live attenuated viruses, whereas many bacterial vaccines are based on acellular components of ... Many antigens derived from acellular vaccines do not strongly induce an adaptive response, and most bacterial vaccines require ... This theory, which builds on established concepts of clonal selection, is being applied in the search for an HIV vaccine. ... is seen as being relevant to the understanding of the HIV pathogenesis and the search for an HIV vaccine. One of the most ...
*  Immune system
Most viral vaccines are based on live attenuated viruses, while many bacterial vaccines are based on acellular components of ... Since many antigens derived from acellular vaccines do not strongly induce the adaptive response, most bacterial vaccines are ... Van de Perre P (Jul 2003). "Transfer of antibody via mother's milk". Vaccine. 21 (24): 3374-6. doi:10.1016/S0264-410X(03)00336- ... These frequent changes in antigens may explain the failures of vaccines directed at this virus. The parasite Trypanosoma brucei ...
*  Arthus reaction
Reduced Diphtheria Toxoid and Acellular Pertussis Vaccines, K. R. Broder et al., MMWR Recommendations and Reports, March 24, ... ACIP has recommended that persons who experienced an Arthus reaction after a dose of tetanus toxoid-containing vaccine should ... Immune complexes form in the setting of high local concentration of vaccine antigens and high circulating antibody ... are rarely reported after vaccination and can occur after tetanus toxoid-containing or diphtheria toxoid-containing vaccines. ...
*  LAG3
... as potential serological markers of T helper-type cytokine response induced by acellular pertussis vaccine". International ... LAG could be used as a biomarker to assess the induction of Th-type responses in recipients of acellular pertussis vaccines. In ... In 1999 Triebel showed that LAG-3 could be used as a cancer vaccine, through cancer cell lines transfected with LAG-3. In 2001 ... April 2007 scientists working at Edward Jenner Institute for Vaccine Research in the UK demonstrated that LAG-3 participates in ...
*  Polio vaccine
In the United States, vaccine is administered along with the tetanus, diphtheria, and acellular pertussis vaccines (DTaP) and a ... The first polio vaccine was the inactivated polio vaccine. It was developed by Jonas Salk and came into use in 1955. The oral ... Oral polio vaccine (OPV) is an attenuated vaccine, produced by the passage of the virus through non-human cells at a sub- ... The inactivated polio vaccines are very safe. Mild redness or pain may occur at the site of injection. Oral polio vaccines ...
*  Herd immunity
Similarly, waning vaccine-induced immunity, as occurs with acellular pertussis vaccines, requires higher levels of booster ... Vaccines against STIs that are targeted at one sex result in significant declines in STIs in both sexes if vaccine uptake in ... Vaccines are usually imperfect however, so the effectiveness, E, of a vaccine must be accounted for: V c = 1 − 1 R 0 E . {\ ... Well-developed vaccines provide protection in a far safer way than natural infections, as vaccines generally do not cause the ...
*  Splinter
... reduced diphtheria toxoid and acellular pertussis vaccines recommendations of the Advisory Committee on Immunization Practices ...
*  Vaccine
... for diphtheria and tetanus toxoids and acellular pertussis vaccine, "DT" for diphtheria and tetanus toxoids, and "Td" for ... Examples include the polio vaccine, hepatitis A vaccine, rabies vaccine and some influenza vaccines.[citation needed] Some ... The first DIVA vaccines (formerly termed marker vaccines and since 1999 coined as DIVA vaccines) and companion diagnostic tests ... the HPV vaccine, and the chicken pox vaccine. The World Health Organization (WHO) reports that licensed vaccines are currently ...
*  National Institute of Allergy and Infectious Diseases
NIAID also was instrumental in the development and licensure of acellular pertussis vaccines, conjugate vaccines for ... "Vaccine Research Center". National Institute of Allergy and Infectious Diseases. Retrieved 1 November 2016. "Vaccine Research ... Vaccine Research Center (VRC) The Dale and Betty Bumpers Vaccine Research Center is composed of four laboratories and two ... Vaccine News Daily reports that Duke University received a $2 million award to start a clinical research network focused on ...
*  Hypotonic-hyporesponsive episode
... and after 1-in 14,286 to 1-in 2,778 doses of acellular pertussis vaccine. "Hypotonic, hyporesponsive episode (HHE)" (PDF). 7 ... An HHE is estimated occur after 1-in 4,762 to 1-in 1,408 doses of whole cell pertussis vaccine, ... "Hypotonic-Hyporesponsive Episodes Reported to the Vaccine Adverse Event Reporting System (VAERS), 1996-1998 , ELECTRONIC ... "Hypotonic-Hyporesponsive Episodes Reported to the Vaccine Adverse Event Reporting System (VAERS), 1996-1998 , ELECTRONIC ...
*  List of MeSH codes (D20)
... vaccines, acellular MeSH D20.215.894.860.900.267 --- diphtheria-tetanus-acellular pertussis vaccines MeSH D20.215.894.860.915 ... diphtheria-tetanus-acellular pertussis vaccines MeSH D20.215.894.135.300 --- diphtheria-tetanus-pertussis vaccine MeSH D20.215. ... pertussis vaccine MeSH D20.215.894.135.535.295 --- diphtheria-tetanus-acellular pertussis vaccines MeSH D20.215.894.135.535.300 ... diphtheria-tetanus-acellular pertussis vaccines MeSH D20.215.894.815.300 --- diphtheria-tetanus-pertussis vaccine MeSH D20.215. ...
*  List of GlaxoSmithKline products
... reduced diphtheria toxoid and acellular pertussis) Cervarix (for human Papillomavirus vaccine (types 16, 18)) Engerix-B (for ... acellular, component) and poliomyelitis) Kinrix (for diphtheria and tetanus toxoids and acellular pertussis adsorbed and ... "Our vaccines". GlaxoSmithKline. Archived from the original on 15 March 2013. Retrieved 14 March 2013. "Our consumer healthcare ... This is a list of products manufactured by the multinational pharmaceutical, biologics, vaccines and consumer healthcare ...